Abstract
We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD), and DM predicted a sevenfold greater risk of chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.
References
1.
Ataga
KI
, Saraf
SL
, Derebail
VK
. The nephropathy of sickle cell trait and sickle cell disease
. Nat Rev Nephrol
. 2022
;18
(6
):361
-377
.2.
Zahr
RS
, Rampersaud
E
, Kang
G
, et al. Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life
. Haematologica
. 2019
;104
(9
):e385
-e387
.3.
Saraf
SL
, Shah
BN
, Zhang
X
, et al. APOL1, alpha-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia
. Haematologica
. 2017
;102
(1
):e1
-e6
.4.
Parsa
A
, Kao
WH
, Xie
D
, et al. APOL1 risk variants, race, and progression of chronic kidney disease
. N Engl J Med
. 2013
;369
(23
):2183
-2196
.5.
Zhou
J
, Han
J
, Nutescu
EA
, et al. Similar burden of type 2 diabetes among adult patients with sickle cell disease relative to African Americans in the U.S. population: a six-year population-based cohort analysis
. Br J Haematol
. 2019
;185
(1
):116
-127
.6.
Zhou
J
, Calip
GS
, Nutescu
EA
, et al. Type 2 diabetes mellitus burdens among adults with sickle cell disease: a 12-year single health system-based cohort analysis
. EJHaem
. 2021
;2
(1
):94
-98
.7.
Cheng
YJ
, Kanaya
AM
, Araneta
MRG
, et al. Prevalence of diabetes by race and ethnicity in the United States, 2011-2016
. JAMA
. 2019
;322
(24
):2389
-2398
.8.
Inker
LA
, Eneanya
ND
, Coresh
J
, et al. New creatinine- and cystatin C-based equations to estimate GFR without race
. N Engl J Med
. 2021
;385
(19
):1737
-1749
.9.
Olaniran
KO
, Allegretti
AS
, Zhao
SH
, et al. Kidney function decline among Black patients with sickle cell trait and sickle cell disease: an observational cohort study
. J Am Soc Nephrol
. 2020
;31
(2
):393
-404
.10.
Derebail
VK
, Ciccone
EJ
, Zhou
Q
, Kilgore
RR
, Cai
J
, Ataga
KI
. Progressive decline in estimated GFR in patients with sickle cell disease: an observational cohort study
. Am J Kidney Dis
. 2019
;74
(1
):47
-55
.11.
American Diabetes Association
. About diabetes: examine the facts
. Accessed 30 October 2024. https://diabetes.org/about-diabetes/statistics.12.
Friedman
DJ
, Kozlitina
J
, Genovese
G
, Jog
P
, Pollak
MR
. Population-based risk assessment of APOL1 on renal disease
. J Am Soc Nephrol
. 2011
;22
(11
):2098
-2105
.13.
Lacy
ME
, Wellenius
GA
, Sumner
AE
, et al. Association of sickle cell trait with hemoglobin A1c in African Americans
. JAMA
. 2017
;317
(5
):507
-515
.14.
Heerspink
HJL
, Stefánsson
BV
, Correa-Rotter
R
, et al. Dapagliflozin in patients with chronic kidney disease
. N Engl J Med
. 2020
;383
(15
):1436
-1446
.15.
Egbuna
O
, Zimmerman
B
, Manos
G
, et al. Inaxaplin for proteinuric kidney disease in persons with two APOL1 variants
. N Engl J Med
. 2023
;388
(11
):969
-979
.2025
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