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Journal Articles

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Ken Morita, MD PhD, Shuning He, PhD, Radosław P. Nowak, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Eric S. Fischer, PhD, A. Thomas Look, MD

Blood (2019) 134 (Supplement_1): 406.

https://doi.org/10.1182/blood-2019-123573

Published: 2019

Journal Articles

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Andrew E. Place, MD PhD, Traci M. Blonquist, MS, Elliot Stieglitz, MD, Todd M Cooper, DO, Lia Gore, MD, Richard Aplenc, MD PhD, Mignon L. Loh, MD, Melinda Pauly, MD, Rachel E. Rau, MD, Michael J. Burke, MD, Julia Etchin, PhD, A. Thomas Look, MD, Maria Luisa Sulis, MD, Lewis B. Silverman, MD

Blood (2018) 132 (Supplement 1): 1405.

https://doi.org/10.1182/blood-2018-99-116689

Published: 2018

Journal Articles

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Koshi Akahane, MD PhD, Zhaodong Li, PhD, Julia Etchin, PhD, Alla Berezovskaya, Evisa Gjini, PhD, Craig E Masse, PhD, Wenyan Miao, PhD, Jennifer Rocnik, PhD, Rosana Kapeller, MD PhD, Jeremy R Greenwood, PhD, Hong Tiv, Takaomi Sanda, MD PhD, David M Weinstock, MD, A. Thomas Look, MD

Blood (2016) 128 (22): 1596.

https://doi.org/10.1182/blood.V128.22.1596.1596

Published: 2016

Journal Articles

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Sunniyat Rahman, PhD DIC, MBiochem, Michael Magnussen, MSc, BSc, Theresa E. León, PhD MSc, BSc, Nadine Farah, FRCPath, MBBChir, MA, MRCP, Brian J. Abraham, PhD BSc, Zhaodong Li, PhD, Krisztina Z. Alapi, PhD MSc, BSc, Rachel J. Mitchell, MSc, Bsc, Tom Naughton, MSc, BSc, Adele K. Fielding, MB BS, PhD FRCP, FRCPath, Arnold Pizzey, Sophia Bustraan, BSc, Christopher Allen, BSc, Rosemary E. Gale, PhD BSc, David C. Linch, MD MRCP, MB BCh, BA, Richard A. Young, PhD BS, A. Thomas Look, MD, Marc R Mansour, MBChB, MRCP, PhD FRCPath

Blood (2016) 128 (22): 733.

https://doi.org/10.1182/blood.V128.22.733.733

Published: 2016

Journal Articles

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Julia Etchin, PhD, Alla Berezovskaya, Amy Saur Conway, Weihsu Claire Chen, PhD, Erkan Baloglu, PhD, Yosef Landesman, PhD, William Senapedis, PhD, Joel Ellis, PhD, Dilara McCauley, PhD, Richard M. Stone, MD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Michael Kauffman, Sharon Shacham, Jean C.Y. Wang, MDPhD, A. Thomas Look, MD

Blood (2015) 126 (23): 326.

https://doi.org/10.1182/blood.V126.23.326.326

Published: 2015

Journal Articles

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Adam Deveau, BSc, MSc, Alexander Michael Forrester, BSc, PhD, Andrew J Coombs, BScH, Gretchen S Wagner, BScH, Clemens Grabher, PhD, Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, Matthew Mingay, BSc, Martin Hirst, PhD, A. Thomas Look, MD, Jason N. Berman, MD

Blood (2014) 124 (21): 436.

https://doi.org/10.1182/blood.V124.21.436.436

Published: 2014

Journal Articles

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD PhD, Marc R Mansour, MDPhD, Alla Berezovskaya, B.S., Richard M. Stone, MD, Ilene Galinsky, RNP, Daniel J. DeAngelo, MDPhD, Dilara McCauley, PhD, Michael Kauffman, MD PhD, Sharon Shacham, PhDMBA, Jean C.Y. Wang, MDPhD, Andrew L Kung, MD PhD, A. Thomas Look, MD

Blood (2014) 124 (21): 995.

https://doi.org/10.1182/blood.V124.21.995.995

Published: 2014

Journal Articles

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

Julia Etchin, PhD, Bonnie Thi Le, M.S., Alex Kentsis, MD, PhD, Richard M. Stone, MD, Dilara McCauley, PhD, Michael Kauffman, MD, PhD, Sharon Shacham, PhD, MBA, Jean C.Y. Wang, MD PhD, Andrew L Kung, MD, PhD, A. Thomas Look, MD

Blood (2013) 122 (21): 3932.

https://doi.org/10.1182/blood.V122.21.3932.3932

Published: 2013

Journal Articles

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

Koshi Akahane, Takaomi Sanda, PhD, Marc R. Mansour, MD PhD FRCPath, Julia Etchin, PhD, Ng Cherry, David M. Weinstock, MD, Anthony Letai, MD, PhD, Daniel J. DeAngelo, MD, Ph.D, A. Thomas Look, MD

Blood (2013) 122 (21): 2528.

https://doi.org/10.1182/blood.V122.21.2528.2528

Published: 2013

Journal Articles

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

Nicole M Anderson, PhD, Hongling Peng, MD, Daniel Helman, BS, Itrat Harrold, PhD, Takaomi Sanda, PhD, Trevor Grant, MS, Nicholas Nagykery, BS, Yasmina Samaha, Meng Le, PhD, Adam Amsterdam, PhD, Donna Neuberg, ScD, Marc R. Mansour, MD PhD FRCPath, Travis Denton, PhD, John Kanki, PhD, Anurag Singh, PhD, A. Thomas Look, MD, Hui Feng, PhD

Blood (2013) 122 (21): 1273.

https://doi.org/10.1182/blood.V122.21.1273.1273

Published: 2013

Journal Articles

MYBL2 Is a Candidate Tumor Suppressor Gene In MDS

Stefan Heinrichs, Lily Conover, Carlos E. Bueso-Ramos, Outi Kilpivaara, Ross Levine, MD, Kristen Stevenson, Donna Neuberg, ScD, Rafael Bejar, MD, PhD, Benjamin L. Ebert, MD, DPhil, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 1865.

https://doi.org/10.1182/blood.V116.21.1865.1865

Published: 2010

Journal Articles

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Maria Virgilio, Elspeth Payne, MBChB, Anupama Narla, MD, Hong Sun, MD, Barry Paw, M.D., Ph.D., A. Thomas Look, MD, Benjamin L. Ebert, MD, DPhil, Nancy Berliner, MD, Arati Khanna-Gupta, PhD

Blood (2010) 116 (21): 195.

https://doi.org/10.1182/blood.V116.21.195.195

Published: 2010

Journal Articles

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

Lynnie A. Rudner, AB, Kim H. Brown, PhD, Kimberly P. Dobrinski, PhD, Diana F. Bradley, BS, Jonathan Downie, BS, Nathan D. Meeker, MD, Alexandra Smith, BA, Martha Iveth Garcia, Alejandro Gutierrez, MD, Charles Mullighan, MBBS, MD, FRACP, FRCPA, MSc, A. Thomas Look, MD, James R. Downing, MD, Joshua D. Schiffman, MD, Charles Lee, PhD, Nikolaus Trede, MD, PhD, J. Kimble Frazer, MD, PhD

Blood (2010) 116 (21): 1192.

https://doi.org/10.1182/blood.V116.21.1192.1192

Published: 2010

Journal Articles

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Julia Etchin, PhD, Alexei Protopopov, PhD, Jianhua Zhang, PhD, Lynda Chin, MD, Lewis B. Silverman, MD, Stuart Winter, MD, Stephen Hunger, MD, Stephen E. Sallan, MD, Shan Zha, PhD, Frederick Alt, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 4177.

https://doi.org/10.1182/blood.V116.21.4177.4177

Published: 2010

Journal Articles

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

Takaomi Sanda, MD, PhD, Jeffrey W Tyner, PhD, Alejandro Gutierrez, MD, Vu N Ngo, PhD, Richard Moriggl, Yebin Ahn, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Louis M. Staudt, MD, PhD, Brian J Druker, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 3155.

https://doi.org/10.1182/blood.V116.21.3155.3155

Published: 2010

Journal Articles

Cleavage and Polyadenylation Specificity Factor 1 Is Required for Definitive Hematopoietic Stem Cell Survival In Zebrafish.

Niccolo Bolli, MD, Elspeth Payne, MBChB, Jennifer Rhodes, PhD, Adam Johnston, Feng Guo, Jeong-Soo Lee, PhD, John Kanki, Aye T. Chen, Yi Zhou, PhD, Leonard I. Zon, MD, A. Thomas Look, MD

Blood (2010) 116 (21): 1606.

https://doi.org/10.1182/blood.V116.21.1606.1606

Published: 2010

Journal Articles

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Jeffrey W Tyner, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Jason M Glover, MD, Bill H Chang, MD, PhD, Stephanie G Willis, Yebin Ahn, A. Thomas Look, MD, Brian J Druker, MD

Blood (2010) 116 (21): 1001.

https://doi.org/10.1182/blood.V116.21.1001.1001

Published: 2010

Journal Articles

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

Alex Kentsis, MD, PhD, Takaomi Sanda, MD, PhD, Vu Ngo, PhD, Scott J. Rodig, MD, PhD, Jeffery Kutok, MD, PhD, Eleni Tholouli, PhD, MRCPath, Richard Byers, PhD, MBChB, FRCPath, George Vande Woude, PhD, Andrew L. Kung, MD, PhD, Louis M. Staudt, MD, PhD, A. Thomas Look, MD

Blood (2010) 116 (21): 1042.

https://doi.org/10.1182/blood.V116.21.1042.1042

Published: 2010

Journal Articles

NUP98-HOXA9 Reprograms Embryonic Hematopoiesis, Suppresses Cellular Apoptosis, and Causes Malignant Tissue Infiltrates in Transgenic Zebrafish.

A. Michael Forrester, BSc(hons), Ellen R. Boyd, BSc(hons), Clemens Grabher, PhD, Eileen R. McBride, MD, Sahar Da'as, MSc, Fui Boon Kai, BSc(hons), A. Thomas Look, MD, Jason N. Berman, MD

Blood (2009) 114 (22): 3961.

https://doi.org/10.1182/blood.V114.22.3961.3961

Published: 2009

Journal Articles

Pten Inactivating Mutations Promote Loss of MYC “Oncogene Addiction” in a Conditional Zebrafish Model of T-ALL.

Alejandro Gutierrez, M.D., Hui Feng, Adele Faucherre, Jeroen Den Hertog, Edward V. Prochownik, MD, PhD, Joseph R. Testa, PhD, John Kanki, A. Thomas Look, MD

Blood (2009) 114 (22): 3977.

https://doi.org/10.1182/blood.V114.22.3977.3977

Published: 2009

NARROW

Targeting T-ALL Cells with Potent Activators of the PP2A Protein Phosphatase Tumor Suppressor

Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia

Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

Activation of the LMO2 Oncogene in T-ALL through a Somatically Acquired Neomorphic Promoter

Nuclear Export Inhibitor KPT-8602 Is Highly Active Against Leukemic Blasts and Leukemia-Initiating Cells in Patient-Derived Xenograft Models of AML

Preclinical Determination of the Efficacy of Epigenetic Therapy in High Risk Myeloid Disease Using the Zebrafish Model

Selective Inhibitor of Nuclear Export (SINE), Selinexor (KPT-330), Shows Remarkable Activity Against AML Leukemia-Initiating Cells

Novel Inhibitors Of CRM1/XPO1 Nuclear Exporter Exhibit Striking Activity Against AML “primagrafts,” Including AML Leukemia Initiating Cells, While Sparing Normal Hematopoietic Cells

HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

A Genetic Screen In Zebrafish Identified Dlst As a Potential Therapeutic Target For Human Acute T-Lymphoblastic Leukemia

MYBL2 Is a Candidate Tumor Suppressor Gene In MDS

Treatment of Zebrafish Models of Ribosomopathies (Diamond Blackfan Anemia (DBA) and 5q- Syndrome) with L-Leucine Results In An Improvement of Anemia and Developmental Defects: Evidence for a Common Pathway?

Cross-Species Comparison of Acquired Genetic Changes In T Cell Malignancy.

The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia

Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia

Cleavage and Polyadenylation Specificity Factor 1 Is Required for Definitive Hematopoietic Stem Cell Survival In Zebrafish.

RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia

Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation Providing a Novel Therapeutic Target In Acute Myeloid Leukemia.

NUP98-HOXA9 Reprograms Embryonic Hematopoiesis, Suppresses Cellular Apoptosis, and Causes Malignant Tissue Infiltrates in Transgenic Zebrafish.

Pten Inactivating Mutations Promote Loss of MYC “Oncogene Addiction” in a Conditional Zebrafish Model of T-ALL.

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American Society of Hematology

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American Society of Hematology

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