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Journal Articles

How I treat transfusional iron overload

A. Victor Hoffbrand, Ali Taher, Maria Domenica Cappellini

Blood (2012) 120 (18): 3657–3669.

https://doi.org/10.1182/blood-2012-05-370098

Published: 2012

Journal Articles

The p90RSK Inhibitor BI-D1870 Induces Apoptosis in CLL Cells

Andrew J Steele, PhD, Archibald G Prentice, MBChB, FRCP, FRCPath, Victoria Last, PhD, A. Victor Hoffbrand, DM, DSc, R G Wickremasinghe

Blood (2011) 118 (21): 2492.

https://doi.org/10.1182/blood.V118.21.2492.2492

Published: 2011

Journal Articles

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment

Andrew J. Steele, Archibald G. Prentice, Kate Cwynarski, A. Victor Hoffbrand, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, R. Gitendra Wickremasinghe

Blood (2010) 116 (22): 4569–4577.

https://doi.org/10.1182/blood-2009-09-245811

Published: 2010

Includes: Supplemental data

Journal Articles

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

Andrew Steele, BSc, MSc, PhD, Archibald G Prentice, MBChB, FRCP, FRCPath, Anastasios Chanalaris, A. Victor Hoffbrand, DM, FRCP, FRCPath, DSc, Kate Cwynarski, Ranmohan Wickremasinghe

Blood (2009) 114 (22): 2752.

https://doi.org/10.1182/blood.V114.22.2752.2752

Published: 2009

Journal Articles

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, Janet M. North, Elisabeth P. Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, R. Gitendra Wickremasinghe

Blood (2009) 114 (6): 1217–1225.

https://doi.org/10.1182/blood-2008-11-190587

Published: 2009

Includes: Supplemental data

Journal Articles

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism

Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Elisabeth P. Nacheva, Julie D. Howard-Reeves, Veronique M. Duke, Panagiotis D. Kottaridis, Kate Cwynarski, Lyubomir T. Vassilev, R. Gitendra Wickremasinghe

Blood (2008) 112 (9): 3827–3834.

https://doi.org/10.1182/blood-2008-05-156380

Published: 2008

Includes: Supplemental data

Journal Articles

Pifithrin α, a Selective Inhibitor of p53-Mediated Transcription, Augments Apoptotic Killing of Chronic Lymphocytic Leukemia Cells by Nutlin 3a and Cytotoxic Drugs.

Andrew J. Steele, Archie Prentice, Kate Cwynarski, A. Victor Hoffbrand, R. Gitendra Wickremasinghe

Blood (2007) 110 (11): 1590.

https://doi.org/10.1182/blood.V110.11.1590.1590

Published: 2007

Journal Articles

Frequency of JAK2 Exon 12 Mutations in JAK2 Exon 14 V617F-Negative Patients: High Frequency in ET Patients.

Veronique M. Duke, PhD, Nicole Gurunlian, Bi Yogashangari, BSc, Tom Colley, MSc, Christopher McNamara, MD, A. Victor Hoffbrand, Letizia Foroni, MD, PhD

Blood (2007) 110 (11): 2539.

https://doi.org/10.1182/blood.V110.11.2539.2539

Published: 2007

Journal Articles

2-Phenylacetylenesulfonamide Upregulates Noxa and Induces p53-Independent Apoptosis of CLL Cells.

Andrew J. Steele, Archie Prentice, Kate Cwynarski, A. Victor Hoffbrand, R. Gitendra Wickremasinghe

Blood (2007) 110 (11): 1609.

https://doi.org/10.1182/blood.V110.11.1609.1609

Published: 2007

Journal Articles

Zap-70 and IgV H Mutation Status in Combination with p53 Functional Analysis Identifies the Response of Poor Prognosis B-CLL Patients to Conventional Cytotoxic Agents.

N. I. Folarin, PhD, R. J. Baker, MSc, V. Duke, PhD, B. C. Yogashangary, BSc, C. Vadikolia, MD, R. G. Wickremasinghe, PhD, A. A. Casanova, BSc, M. W. Lowdell, PhD, A. Victor Hoffbrand, DSc, A. Nathwani, MD, A. E. Virchis, MD, A. B. Mehta, MD, L. Foroni, MD, K. Ganeshaguru, PhD

Blood (2004) 104 (11): 1907.

https://doi.org/10.1182/blood.V104.11.1907.1907

Published: 2004

Journal Articles

Conserved Amino Acid Sequences Occur in a Limited Group of CLL Patients with Predominantly Mutated IGH Rearrangements.

Veronique M. Duke, BSc PhD, Birithini Yogashangari, BSc, Domenica Gandini, MD PhD, Paul D. Sherrington, MD PhD, Atul Mehta, MD, A. Victor Hoffbrand, Letizia Foroni, MD PhD

Blood (2004) 104 (11): 2000.

https://doi.org/10.1182/blood.V104.11.2000.2000

Published: 2004

Journal Articles

The Role of Multidrug Resistance Proteins and Drug Sensitivity in Relation to Poor Prognosis Identified by ZAP-70 Expression and IgV H Mutation Status in B-CLL.

S. Narat, MD, N. I. Folarin, PhD, R. J. Baker, MSc, V. Duke, PhD, B. C. Yogashangary, BSc, D. T. Jones, PhD, S. M. Hart, PhD, R. G. Wickremasinghe, PhD, A. Victor Hoffbrand, DSc, A. B. Mehta, MD, L. Foroni, MD, K. Ganeshaguru, PhD

Blood (2004) 104 (11): 4791.

https://doi.org/10.1182/blood.V104.11.4791.4791

Published: 2004

Journal Articles

Glucosylceramide Synthetase Inhibitors Sensitise B-CLL Cells to Cytotoxic Agents without Reversing P-gp Functional Activity.

Gareth Gerrard, MSc, Terry D. Butters, PhD, Atul B. Mehta, MD, A. Victor Hoffbrand, DSc, Derryln Hughes, MD, Michael Burgess, MD, Kanagasabai Ganeshaguru, PhD

Blood (2004) 104 (11): 1181.

https://doi.org/10.1182/blood.V104.11.1181.1181

Published: 2004

Journal Articles

The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.

Andrew J. Steele, PhD, Anouska A. Casanova, BSc, A. Victor Hoffbrand, DSc, Atul B. Mehta, MD, Kanagasabai Ganeshaguru, PhD, Dylan T. Jones, PhD, R. Gitendra Wickremasinghe, PhD

Blood (2004) 104 (11): 3483.

https://doi.org/10.1182/blood.V104.11.3483.3483

Published: 2004

Journal Articles

Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

Dylan T. Jones, Elena Addison, Janet M. North, Mark W. Lowdell, A. Victor Hoffbrand, Atul B. Mehta, Kanagasabai Ganeshaguru, Najeem I. Folarin, R. Gitendra Wickremasinghe

Blood (2004) 103 (5): 1855–1861.

https://doi.org/10.1182/blood-2003-05-1603

Published: 2004

Journal Articles

Role of deferiprone in chelation therapy for transfusional iron overload

A. Victor Hoffbrand, Alan Cohen, Chaim Hershko

Blood (2003) 102 (1): 17–24.

https://doi.org/10.1182/blood-2002-06-1867

Published: 2003

Journal Articles

Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

Dylan T. Jones, Kanagasabai Ganeshaguru, Robert J. Anderson, Trevor R. Jackson, K. Richard Bruckdorfer, Sylvia Y. Low, Lars Palmqvist, H. Grant Prentice, A. Victor Hoffbrand, Atul B. Mehta, R. Gitendra Wickremasinghe

Blood (2003) 101 (8): 3174–3180.

https://doi.org/10.1182/blood-2002-07-2143

Published: 2003

Journal Articles

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

Dylan T. Jones, Kanagasabai Ganeshaguru, Andres E. Virchis, Najeem I. Folarin, Mark W. Lowdell, Atul B. Mehta, H. Grant Prentice, A. Victor Hoffbrand, R. Gitendra Wickremasinghe

Blood (2001) 98 (9): 2800–2807.

https://doi.org/10.1182/blood.V98.9.2800

Published: 2001

Journal Articles

Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies

R. Gitendra Wickremasinghe, A. Victor Hoffbrand

Blood (1999) 93 (11): 3587–3600.

https://doi.org/10.1182/blood.V93.11.3587

Published: 1999

Journal Articles

Long-Term Trial of Deferiprone in 51 Transfusion-Dependent Iron Overloaded Patients

A. Victor Hoffbrand, Faris AL-Refaie, Bernard Davis, Noppadol Siritanakatkul, Beverly F.A. Jackson, John Cochrane, Emma Prescott, Beatrix Wonke

Blood (1998) 91 (1): 295–300.

https://doi.org/10.1182/blood.V91.1.295

Published: 1998

NARROW

How I treat transfusional iron overload

The p90RSK Inhibitor BI-D1870 Induces Apoptosis in CLL Cells

The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment

Induction of Noxa Via Generation of Reactive Oxygen Species Plays a Key Role in Induction of CLL Cell Apoptosis by Two Novel p53-Independent Cytotoxic Agents.

2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism

Pifithrin α, a Selective Inhibitor of p53-Mediated Transcription, Augments Apoptotic Killing of Chronic Lymphocytic Leukemia Cells by Nutlin 3a and Cytotoxic Drugs.

Frequency of JAK2 Exon 12 Mutations in JAK2 Exon 14 V617F-Negative Patients: High Frequency in ET Patients.

2-Phenylacetylenesulfonamide Upregulates Noxa and Induces p53-Independent Apoptosis of CLL Cells.

Zap-70 and IgV H Mutation Status in Combination with p53 Functional Analysis Identifies the Response of Poor Prognosis B-CLL Patients to Conventional Cytotoxic Agents.

Conserved Amino Acid Sequences Occur in a Limited Group of CLL Patients with Predominantly Mutated IGH Rearrangements.

The Role of Multidrug Resistance Proteins and Drug Sensitivity in Relation to Poor Prognosis Identified by ZAP-70 Expression and IgV H Mutation Status in B-CLL.

Glucosylceramide Synthetase Inhibitors Sensitise B-CLL Cells to Cytotoxic Agents without Reversing P-gp Functional Activity.

The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.

Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs

Role of deferiprone in chelation therapy for transfusional iron overload

Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies

Long-Term Trial of Deferiprone in 51 Transfusion-Dependent Iron Overloaded Patients

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American Society of Hematology

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American Society of Hematology

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