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Aaron D. Schimmer, MDPhD
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Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 814.
https://doi.org/10.1182/blood.V130.Suppl_1.814.814
Published: 2017
Journal Articles

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, PhD, G. Wei Xu, Rob C. Laister, PhD, Zachary Blatman, Troy Ketela, Mark D. Minden, MD PhD, Atan Gross, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 299.
https://doi.org/10.1182/blood.V130.Suppl_1.299.299
Published: 2017
Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 881.
https://doi.org/10.1182/blood.V130.Suppl_1.881.881
Published: 2017
Journal Articles

Patients Who Are Refractory to Ida-FLAG As Initial Induction Chemotherapy for AML Have Persistence of the Dominant Genetic Mutations and a Poor Clinical Outcome

Simon Kavanagh, Emily Heath, Rose Hurren, BSc, Samir H. Barghout, BSPharm, MSc, Sanduni U. Liyanage, Hon. B. Sc, PhD, Thirushi Siriwardena, Jaime Claudio, Tong Zhang, Mahadeo Sukhai, Tracy L. Stockley, Suzanne Kamel-Reid, Amr Rostom, MD, Dina Khalaf, BSc, MSc, MD, Andrzej Lutynski, Anna Rydlewski, MD, Andre C. Schuh, MD FRCPC, Vikas Gupta, MD PhD, Hassan Sibai, MBBS, Dawn Maze, MD FRCPC, MSc, Steven M. Chan, MDPhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2596.
https://doi.org/10.1182/blood.V130.Suppl_1.2596.2596
Published: 2017
Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2524.
https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524
Published: 2017
Journal Articles

Comparison of the Impact of Two Different Definitions of Red-Cell Transfusion Dependence on the Natural History of Myeloproliferative Neoplasm (MPN)-Associated Myelofibrosis (MF)

Justyna Bartoszko, Tony Panzerella, Anthea Lau, Naheed Alam, MBBS,MD, Aaron D Schimmer, MDPhD, Matthew D. Seftel, MRCP, FRCPC, MPH, Andre C Schuh, MD FRCPC, Mohamed Shanavas, MD FRACP, FRCPA, Karen W.L. Yee, MDFRCPC, Vikas Gupta, MD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 3180.
https://doi.org/10.1182/blood.V124.21.3180.3180
Published: 2014
Journal Articles

Diagnosis of Blastic Plasmacytoid Dendritic Cell Neoplasm By Using 10-Colour Flow Cytometry and Achievement of Remission By Hypercvad Therapy

Uday Deotare, MD DM, Elizabeth Hyjek, MD PhD, Anna Porwit, MDPhD, Rumina Musani, MDFCAP, FRCPC, David Barth, MD FRCPC, Emina Torlakovic, MD, Anne Tierens, MD PhD, Aaron D Schimmer, MDPhD, Andre C Schuh, MD FRCPC, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, Matthew D. Seftel, MRCP, FRCPC, MPH, Naheed Alam, MBBS,MD, Karen W.L. Yee, MDFRCPC
Journal: Blood
Blood (2014) 124 (21): 2365.
https://doi.org/10.1182/blood.V124.21.2365.2365
Published: 2014
Journal Articles

Ibrutinib Sensitizes AML Cells to ROS Inducers Via a BTK-Independent Mechanism

Lianne E Rotin, BHSc, Marcela Gronda, MSc, Neil Maclean, BSc, Feng-Hsu Lin, PhD, Jeff Wrana, PhD, Alessandro Datti, PhD, Dwayne L Barber, PhD, Michael F Moran, PhD, Mark D Minden, MDPhD, Malik Slassi, PhD, Aaron D Schimmer, MDPhD
Journal: Blood
Blood (2014) 124 (21): 2226.
https://doi.org/10.1182/blood.V124.21.2226.2226
Published: 2014
Journal Articles

Predictive Value of Molecular Remissions Post Consolidation Chemotherapy in Patients with Core Binding Factor (CBF) Acute Myeloid Leukemias – a Single Centre Analysis

Uday Deotare, MD DM, Marwan Shaheen, MD, Joseph M. Brandwein, MD FRCPC, Bethany Gill, BSc, MMath, Suzanne Kamel-Reid, PhD DABMG, FACMG, Karen W.L. Yee, MDFRCPC, Anna Rydlewski, MD, Andrzej Lutynski, MD, Amr Rostom, MDCFPC, Aaron D Schimmer, MDPhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, Matthew D. Seftel, MRCP, FRCPC, MPH, Naheed Alam, MBBS,MD, Andre C Schuh, MD FRCPC
Journal: Blood
Blood (2014) 124 (21): 3693.
https://doi.org/10.1182/blood.V124.21.3693.3693
Published: 2014