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Journal Articles

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

Yuji Nakata, Anne C. Brignier, Shenghao Jin, Yuan Shen, Stephen I. Rudnick, Mayumi Sugita, Alan M. Gewirtz

Blood (2010) 116 (8): 1280–1290.

https://doi.org/10.1182/blood-2009-05-223255

Published: 2010

Includes: Supplemental data

Journal Articles

A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells

Anna Kalota, Alan M. Gewirtz

Blood (2010) 115 (1): 89–93.

https://doi.org/10.1182/blood-2009-06-227751

Published: 2010

Includes: Supplemental data

Journal Articles

C-Myb and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression, with the Most Profound Effect On IL-13.

Teruhiko Kozuka, MD, Alan M. Gewirtz, MD, Yuji Nakata, MD

Blood (2009) 114 (22): 3669.

https://doi.org/10.1182/blood.V114.22.3669.3669

Published: 2009

Journal Articles

The Acetyl-Transferase Tip60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia.

Huiwu Zhao, PhD, Shenghao Jin, PhD, Alan M. Gewirtz, MD

Blood (2009) 114 (22): 3981.

https://doi.org/10.1182/blood.V114.22.3981.3981

Published: 2009

Journal Articles

C-Myb Associates with MLL1 through Menin, Augments MLL1's H3K4 Methylation Activity, and Regulates Hoxa9 and Meis1 Gene Expression in Primary Human Leukemia Cells.

Shenghao Jin, PhD, Huiwu Zhao, PhD, Yan Yi, PhD, Yuji Nakata, MD, Anna Kalota, PhD, Alan M. Gewirtz, MD

Blood (2009) 114 (22): 448.

https://doi.org/10.1182/blood.V114.22.448.448

Published: 2009

Journal Articles

The c- myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells

Huiwu Zhao, Anna Kalota, Shenghao Jin, Alan M. Gewirtz

Blood (2009) 113 (3): 505–516.

https://doi.org/10.1182/blood-2008-01-136218

Published: 2009

Journal Articles

Trisomy 21 enhances human fetal erythro-megakaryocytic development

Stella T. Chou, Joanna B. Opalinska, Yu Yao, Myriam A. Fernandes, Anna Kalota, John S. J. Brooks, John K. Choi, Alan M. Gewirtz, Gwenn-ael Danet-Desnoyers, Richard L. Nemiroff, Mitchell J. Weiss

Blood (2008) 112 (12): 4503–4506.

https://doi.org/10.1182/blood-2008-05-157859

Published: 2008

Includes: Supplemental data

Journal Articles

Initial Safety, Pharmacokinetic and Pharmacodynamic Data from a Phase I Clinical Trial of Systemic C-MYB Antisense Oligodeoxynucleotide in Subjects with Refractory Hematologic Malignancies

Noelle V Frey, Anna Kalota, Melissa Potuzak, Doris Shank, Cezary R Swider, Alison Loren, Edward Stadtmauer, Alexander Perl, Adam Cuker, Barbara Konkle, Suman Sood, Steven Goldstein, Margaret Kasner, David L Porter, Selina M Luger, Alan M Gewirtz

Blood (2008) 112 (11): 4033.

https://doi.org/10.1182/blood.V112.11.4033.4033

Published: 2008

Journal Articles

Phosphoproteomic Analysis of Primary Acute Myeloid Leukemia Cells Reveals Redundant Roles for Src Family Kinases in AML Survival

Jamil K. Dierov, MD, PhD, DSc, Tae Kon Kim, Xiaowei Yang, Ph.D., Alexander Perl, MD, Beth A Burke, BS, Zhu Wang, Ting-Lei Gu, Alan M. Gewirtz, MD, Seth J. Corey, Roberto Polakiewicz, Ph.D., Martin Carroll, MD

Blood (2008) 112 (11): 2650.

https://doi.org/10.1182/blood.V112.11.2650.2650

Published: 2008

Journal Articles

GATA-3 Requires C-Myb to Auto-Regulate Its Own Expression in Normal Human Peripheral Blood Lymphocytes Undergoing T Helper Type 2 (Th2) Cell Development

Yuji Nakata, MD, Shenghao Jin, Yuan Shen, MD, Alan M. Gewirtz, MD

Blood (2008) 112 (11): 2575.

https://doi.org/10.1182/blood.V112.11.2575.2575

Published: 2008

Journal Articles

A Nonpeptidyl, Hydrazone Class, Thrombopoietin Receptor Agonist (TpoRA), SB559457, Selectively Kills Primary Human Myeloid Leukemia Cells

Anna Kalota, PhD, Alan M. Gewirtz, MD

Blood (2008) 112 (11): 2636.

https://doi.org/10.1182/blood.V112.11.2636.2636

Published: 2008

Journal Articles

c-Myb Functions as a Co-Activator of MLL1 through Menin, and More Globally Affects Histone Methylation.

Shenghao Jin, PhD, Huiwu Zhao, Ph.D, Alan M. Gewirtz, MD

Blood (2007) 110 (11): 827.

https://doi.org/10.1182/blood.V110.11.827.827

Published: 2007

Journal Articles

c-Myb Contributes to Normal Human Peripheral Blood T Helper 2 Cell Development through Regulation of GATA-3 Expression.

Yuji Nakata, MD, Alan M. Gewirtz, MD

Blood (2007) 110 (11): 793.

https://doi.org/10.1182/blood.V110.11.793.793

Published: 2007

Journal Articles

A New Subtype of T-Cell Acute Leukemia in Very Young Children Is Defined by a Translocation Targeting the C-MYB Oncogene, and a Specific Gene Expression Signature.

Emmanuelle Clappier, Wendy Cuccuini, Anna Kalota, Antoine Crinquette, Jean-Michel Cayuela, PhD, Willem A. Dik, PhD, Anton W. Langerak, PhD, Bertrand Montpellier, Bertrand Nadel, PhD, Pierre Walrafen, PhD, Alain Aurias, MD, Thierry Leblanc, MD, Herve Dombret, MD, Alan M. Gewirtz, MD, Andre Baruchel, MD, Francois Sigaux, MD, Jean Soulier, MD, PhD

Blood (2007) 110 (11): 982.

https://doi.org/10.1182/blood.V110.11.982.982

Published: 2007

Journal Articles

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children

Emmanuelle Clappier, Wendy Cuccuini, Anna Kalota, Antoine Crinquette, Jean-Michel Cayuela, Willem A. Dik, Anton W. Langerak, Bertrand Montpellier, Bertrand Nadel, Pierre Walrafen, Olivier Delattre, Alain Aurias, Thierry Leblanc, Hervé Dombret, Alan M. Gewirtz, André Baruchel, François Sigaux, Jean Soulier

Blood (2007) 110 (4): 1251–1261.

https://doi.org/10.1182/blood-2006-12-064683

Published: 2007

Includes: Supplemental data

Journal Articles

MDM2 Promotes Ubiquitin-Independent Degradation of HoxA9: Implications for MLL-Fusion Protein Mediated Transformation.

Huiwu Zhao, PhD, Shenghao Jin, Ph.D., Alan M. Gewirtz, M.D.

Blood (2006) 108 (11): 1418.

https://doi.org/10.1182/blood.V108.11.1418.1418

Published: 2006

Journal Articles

Myb Family Transcription Factors Contribute to G2/M Cell Cycle Transition in Normal and Malignant Hematopoietic Cells by Direct Regulation of Cyclin B1 Expression.

Yuji Nakata, MD, Susan Shetzline, PHD, Chizuko Sakashita, MD, Anna Kalota, MA, Stephen I. Rudnick, PhD, Alan M. Gewirtz, MD

Blood (2006) 108 (11): 1115.

https://doi.org/10.1182/blood.V108.11.1115.1115

Published: 2006

Journal Articles

c-Myb-Interacting Proteins and Their Functions.

Shenghao Jin, PhD, Huiwu Zhao, Ph.D., Alan M. Gewirtz, MD

Blood (2006) 108 (11): 1423.

https://doi.org/10.1182/blood.V108.11.1423.1423

Published: 2006

Journal Articles

The Proto-Oncogene Myb Augments Transcription of the Neuropeptide Neuromedin U in Human Myeloid Leukemias.

Susan E. Shetzline, PhD, Joseph Conlon, B.S., Cezary Swider, Ph.D., Lindsay Thalheim, B.S., Alan M. Gewirtz, M.D.

Blood (2006) 108 (11): 2254.

https://doi.org/10.1182/blood.V108.11.2254.2254

Published: 2006

Journal Articles

Computationally Designed, Small Molecule Inhibitors of Tubulin Inhibit the Growth of Gleevec Resistant Chronic Myelogenous Leukemia Cells.

Anna Kalota, MS, Alan M. Gewirtz, MD

Blood (2006) 108 (11): 2173.

https://doi.org/10.1182/blood.V108.11.2173.2173

Published: 2006

NARROW

c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development

A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells

C-Myb and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression, with the Most Profound Effect On IL-13.

The Acetyl-Transferase Tip60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia.

C-Myb Associates with MLL1 through Menin, Augments MLL1's H3K4 Methylation Activity, and Regulates Hoxa9 and Meis1 Gene Expression in Primary Human Leukemia Cells.

The c- myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells

Trisomy 21 enhances human fetal erythro-megakaryocytic development

Initial Safety, Pharmacokinetic and Pharmacodynamic Data from a Phase I Clinical Trial of Systemic C-MYB Antisense Oligodeoxynucleotide in Subjects with Refractory Hematologic Malignancies

Phosphoproteomic Analysis of Primary Acute Myeloid Leukemia Cells Reveals Redundant Roles for Src Family Kinases in AML Survival

GATA-3 Requires C-Myb to Auto-Regulate Its Own Expression in Normal Human Peripheral Blood Lymphocytes Undergoing T Helper Type 2 (Th2) Cell Development

A Nonpeptidyl, Hydrazone Class, Thrombopoietin Receptor Agonist (TpoRA), SB559457, Selectively Kills Primary Human Myeloid Leukemia Cells

c-Myb Functions as a Co-Activator of MLL1 through Menin, and More Globally Affects Histone Methylation.

c-Myb Contributes to Normal Human Peripheral Blood T Helper 2 Cell Development through Regulation of GATA-3 Expression.

A New Subtype of T-Cell Acute Leukemia in Very Young Children Is Defined by a Translocation Targeting the C-MYB Oncogene, and a Specific Gene Expression Signature.

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children

MDM2 Promotes Ubiquitin-Independent Degradation of HoxA9: Implications for MLL-Fusion Protein Mediated Transformation.

Myb Family Transcription Factors Contribute to G2/M Cell Cycle Transition in Normal and Malignant Hematopoietic Cells by Direct Regulation of Cyclin B1 Expression.

c-Myb-Interacting Proteins and Their Functions.

The Proto-Oncogene Myb Augments Transcription of the Neuropeptide Neuromedin U in Human Myeloid Leukemias.

Computationally Designed, Small Molecule Inhibitors of Tubulin Inhibit the Growth of Gleevec Resistant Chronic Myelogenous Leukemia Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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