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Journal Articles

Epigenetic reprogramming sensitizes immunologically silent EBV + lymphomas to virus-directed immunotherapy

Tanner Dalton, Ekaterina Doubrovina, Dmitry Pankov, Raymond Reynolds, Hanna Scholze, Annamalai Selvakumar, Teresa Vizconde, Bhumesh Savalia, Vadim Dyomin, Christoph Weigel, Christopher C. Oakes, Alicia Alonso, Olivier Elemento, Heng Pan, Jude M. Phillip, Richard J. O’Reilly, Benjamin E. Gewurz, Ethel Cesarman, Lisa Giulino-Roth

Blood (2020) 135 (21): 1870–1881.

https://doi.org/10.1182/blood.2019004126

Published: 2020

Includes: Supplemental data

Journal Articles

Adoptively Transferred CMV-Specific T-Cells Responsive to Immunodominant CMVpp65 Epitopes Extend Durable in-Vivo Suppression of Clonogenic CMVpp65 [+] Human Colon Carcinoma Cells in Comparison to T-Cells Responsive to Subdominant Epitopes

Aisha N Hasan, MD, Annamalai Selvakumar, PhD, Tzu-Yun Kuo, Richard J O'Reilly, MD

Blood (2015) 126 (23): 4298.

https://doi.org/10.1182/blood.V126.23.4298.4298

Published: 2015

Journal Articles

Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific T h 1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

Aisha N. Hasan, MD, Rosanna J. Ricafort, MD, Annamalai Selvakumar, PhD, Ekaterina Doubrovina, MD, PhD, Isabelle Riviere, Michel Sadelain, MD, PhD, Richard J. O'Reilly, MD

Blood (2012) 120 (21): 1905.

https://doi.org/10.1182/blood.V120.21.1905.1905

Published: 2012

Journal Articles

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1 + leukemias

Ekaterina Doubrovina, Taissia Carpenter, Dmitry Pankov, Annamalai Selvakumar, Aisha Hasan, Richard J. O'Reilly

Blood (2012) 120 (8): 1633–1646.

https://doi.org/10.1182/blood-2011-11-394619

Published: 2012

Journal Articles

CMV-Specific T-Cells Are More Effective Than WT-1-Specific T-Cells in Eradicating Clonogenic Tumor Cells Co-Expressing CMVpp65 and WT-1 in-Vivo and Both Types of T-Cells Are Functionally Augmented in the Presence of IL-15/IL-15Rα

Aisha Hasan, MD, Dana Bakalar, B.S, Annamalai Selvakumar, PhD, Gloria C Koo, PhD, Ekaterina Doubrovina, MD, PhD, Tzu-Yun Kuo, M.S, Richard J. O'Reilly, MD

Blood (2011) 118 (21): 646.

https://doi.org/10.1182/blood.V118.21.646.646

Published: 2011

Journal Articles

The Capacity of CMV-Specific T-Cells to Prevent Outgrowth of Clonogenic Human Colon Carcinoma Cells Co-Expressing CMVpp65 in-Vivo and Durably Suppress Established CMVpp65 + Tumor Xenografts Is Dose Dependant and Can Be Augmented by IL-15/IL-15Rα

Aisha Hasan, MD, Annamalai Selvakumar, PhD, Gloria C Koo, PhD, Dana Bakalar, B.S, Richard J. O’Reilly, MD

Blood (2011) 118 (21): 4307.

https://doi.org/10.1182/blood.V118.21.4307.4307

Published: 2011

Journal Articles

Generation of T Cells of Desired HLA Restriction Specific for Epitopes of a Self-Antigen, WT1, for the Adoptive Immunotherapy of WT1 Positive Malignancies Using A Panel of Artificial Antigen Presenting Cells Expressing Prevalent HLA Alleles.

Ekaterina Doubrovina, MD, PhD, Aisha Hasan, MD, Banu Oflaz-Sozmen, MD, Annamalai Selvakumar, Michel W Sadelain, MD, PhD, Richard J O'Reilly, MD

Blood (2009) 114 (22): 4086.

https://doi.org/10.1182/blood.V114.22.4086.4086

Published: 2009

Journal Articles

Quantitation of WT1 Transcripts by Copy Number Provides a Sensitive Indication of Minimal Residual Disease (MRD) and Response to Adoptive Cell Therapy in Patients Transplanted for Ph(+) CML.

Annamalai Selvakumar, PhD, Aisha Hasan, MD, Vidhi Desai, MS, Gianfranco Pittari, MD, Lorna Barnett, BS, Esperanza B Papadopoulos, MD, Richard J O'Reilly, MD

Blood (2009) 114 (22): 4489.

https://doi.org/10.1182/blood.V114.22.4489.4489

Published: 2009

Journal Articles

Genetic Allelic Variation in the p53 DNA Repair Pathway Constitute a Risk Factor for Long-Term Survival in Hematopoietic Stem Cell Transplantation

Stige. Bojesen, Mari Malkki, Ted Gooley, Lue Ping Zhao, Annamalai Selvakumar, Stephen R Spellman, MS, Effie W Petersdorf, MD, John A. Hansen, MD, Bo Dupont

Blood (2008) 112 (11): 337.

https://doi.org/10.1182/blood.V112.11.337.337

Published: 2008

Journal Articles

IL-15 Augments in-Vitro Expansion and Functional Activity of Antigen-Specific Effector Memory T-Cells (T EM ) While Co-Expression of IL-15 and IL-15 Rα on Antigen Presenting Cells Also Promotes Expansion of Central Memory T-Cells (T CM )

Aisha Hasan, MD, Annamalai Selvakumar, PhD, Bo Dupont, MD, DSc, Michel Sadelain, MD, Isabelle Riviere, PhD, Richard J O’Reilly, MD

Blood (2008) 112 (11): 3541.

https://doi.org/10.1182/blood.V112.11.3541.3541

Published: 2008

NARROW

Epigenetic reprogramming sensitizes immunologically silent EBV + lymphomas to virus-directed immunotherapy

Adoptively Transferred CMV-Specific T-Cells Responsive to Immunodominant CMVpp65 Epitopes Extend Durable in-Vivo Suppression of Clonogenic CMVpp65 [+] Human Colon Carcinoma Cells in Comparison to T-Cells Responsive to Subdominant Epitopes

Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific T h 1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1 + leukemias

CMV-Specific T-Cells Are More Effective Than WT-1-Specific T-Cells in Eradicating Clonogenic Tumor Cells Co-Expressing CMVpp65 and WT-1 in-Vivo and Both Types of T-Cells Are Functionally Augmented in the Presence of IL-15/IL-15Rα

The Capacity of CMV-Specific T-Cells to Prevent Outgrowth of Clonogenic Human Colon Carcinoma Cells Co-Expressing CMVpp65 in-Vivo and Durably Suppress Established CMVpp65 + Tumor Xenografts Is Dose Dependant and Can Be Augmented by IL-15/IL-15Rα

Generation of T Cells of Desired HLA Restriction Specific for Epitopes of a Self-Antigen, WT1, for the Adoptive Immunotherapy of WT1 Positive Malignancies Using A Panel of Artificial Antigen Presenting Cells Expressing Prevalent HLA Alleles.

Quantitation of WT1 Transcripts by Copy Number Provides a Sensitive Indication of Minimal Residual Disease (MRD) and Response to Adoptive Cell Therapy in Patients Transplanted for Ph(+) CML.

Genetic Allelic Variation in the p53 DNA Repair Pathway Constitute a Risk Factor for Long-Term Survival in Hematopoietic Stem Cell Transplantation

IL-15 Augments in-Vitro Expansion and Functional Activity of Antigen-Specific Effector Memory T-Cells (T EM ) While Co-Expression of IL-15 and IL-15 Rα on Antigen Presenting Cells Also Promotes Expansion of Central Memory T-Cells (T CM )

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American Society of Hematology

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ASH Publications

American Society of Hematology

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