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Journal Articles

Bone Marrow Stromal Cell Mediated Drug Resistance in AML Cells: Role of Extracellular Vesicles and AKT Signaling

Hamenth kumar Palani, MSc, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Uday Prakash Kulkarni, MD DM, Alok Srivastava, MD, Biju George, MDDM, Poonkuzhali Balasubramanian, MSc, PhD, Vikram Mathews, MD DM

Blood (2017) 130 (Supplement 1): 1160.

https://doi.org/10.1182/blood.V130.Suppl_1.1160.1160

Published: 2017

Journal Articles

Stromal-Cells Downregulate MiR-23a-5p Levels in Myeloid Leukemic Cells to Activate Protective-Autophagy Against Chemotherapeutic Agents

Saravanan Ganesan, MSc, Hamenth kumar Palani, MSc, Vairavan Lakshmanan, B.Tech, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Arvind Venkatraman, M.Tech, Uday Prakash Kulkarni, MD DM, Biju George, MDDM, Alok Srivastava, MD, Poonkuzhali Balasubramanian, MSc, PhD, Keshava K Datta, MSc, Harsha Gowda, PhD, Dasaradhi Palakodeti, PhD, Neha Vyas, PhD, Vikram Mathews, MD DM

Blood (2017) 130 (Supplement 1): 3780.

https://doi.org/10.1182/blood.V130.Suppl_1.3780.3780

Published: 2017

Journal Articles

Fate of Ikaros in Multiple Myeloma Cells upon Treatment with Lenalidomide and Proteasome Inhibitor

Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anup Joseph Devasia, MD DM, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 3281.

https://doi.org/10.1182/blood.V128.22.3281.3281

Published: 2016

Journal Articles

Metabolic Rewiring Drives Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia

Nithya Balasundaram, MSc, Saravanan Ganesan, MSc, Hamenth Kumar Palani, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anu Korula, MD DM, Biju George, MD DM, Christine Chomienne, MD PhD, Poonkuzhali Balasubramanian, MSc PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 3956.

https://doi.org/10.1182/blood.V128.22.3956.3956

Published: 2016

Journal Articles

Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells

Saravanan Ganesan, MSc, Hamenth Kumar Palani, MSc, Vairavan Lakshmanan, B.Tech, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Neha Vyas, PhD, Dasaradhi Palakodeti, PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 5062.

https://doi.org/10.1182/blood.V128.22.5062.5062

Published: 2016

Journal Articles

Role of miRNA in Micro-Environment Mediated Drug Resistance in Acute Promyelocytic Leukemia to Arsenic Trioxide

Saravanan Ganesan, MSc, Vairavan Lakshmanan, B.Tech, Hamenth Kumar Palani, MSc, Nithya Balasundaram, MSc, Ansu Abu Alex, MSc, Sachin David, MSc, Anu Korula, MD DM, Biju George, MD DM, Poonkuzhali Balasubramanian, MSc PhD, Harsha Gowda, PhD, Neha Vyas, PhD, Dasaradhi Palakodeti, PhD, Vikram Mathews, MD DM

Blood (2016) 128 (22): 5125.

https://doi.org/10.1182/blood.V128.22.5125.5125

Published: 2016

Journal Articles

Management of Relapsed Acute Promyelocytic Leukemia Post ATO Upfront Therapy: Open-Labeled Phase II Study Evaluating Role of Proteasome Inhibition

Vikram Mathews, MD DM, Anu Korula, MD DM, Uday Kulkarni, MD, Saravanan Ganesan, MSc, Sachin David, MSc, Ansu Abu Alex, MSc, Nisham PN, MD DM, Aby Abraham, MD DM, Alok Srivastava, Kavitha M Lakshmi, MSc, Poonkuzhali Balasubramanian, MSc PhD, Biju George, MD DM

Blood (2016) 128 (22): 446.

https://doi.org/10.1182/blood.V128.22.446.446

Published: 2016

Journal Articles

Arsenic Trioxide Resistance: More to It Than Mutations in PML-RARα

Ansu Abu Alex, MSc, Ezhilarasi Chendamarai, PhD, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Sachin David, MSc, Vikram Mathews, MD

Blood (2014) 124 (21): 3605.

https://doi.org/10.1182/blood.V124.21.3605.3605

Published: 2014

Journal Articles

The Addition of Meloxicam to G-CSF Is Associated with Good Mobilization Rates, Faster Engraftment and Reduced Toxicity and Hospital Stay after Autologous Stem Cell Transplantation – a Phase II Study

Biju George, MD, Auro Viswabandya, MD, Ansu Abu Alex, MSc,, Kavitha M Lakshmi, MSc, Aby Abraham, MD, Abhijeet Ganapule, MD, Fouzia N, Alok Srivastava, MD, Vikram Mathews, MD

Blood (2014) 124 (21): 2455.

https://doi.org/10.1182/blood.V124.21.2455.2455

Published: 2014

Journal Articles

Proteasome Activity Is Dispensable for the Degradation of PML-RARα: Efficacy of Bortezomib Along with Arsenic Trioxide in the Treatment of Arsenic Sensitive and Resistant Acute Promyelocytic Leukemia

Saravanan Ganesan, MSc, Ansu Abu Alex, MSc, Ezhilarasi Chendamarai, PhD, Nithya Balasundaram, MSc, Hamenth Kumar Palani, MSc, Sachin David, MSc, Jayandharan G Rao, PhD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Poonkuzhali Balasubramanian, PhD, Rose Ann Padua, PhD, Christine Chomienne, MD PhD, Vikram Mathews, MD

Blood (2014) 124 (21): 3741.

https://doi.org/10.1182/blood.V124.21.3741.3741

Published: 2014

Journal Articles

NK Cell Mediated Cytotoxicity Against Malignant Promyelocytes Enhanced By Arsenic Trioxide: Potential Clinical Relevance

Ansu Abu Alex, MSc, Hamenth Kumar P, MSc, Saravanan Ganesan, MSc, Nithya Balasundaram, MSc, Kavitha M Lakshmi, MSc, Biju George, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Rose Ann Padua, PhD, Christine Chomienne, MD, PhD, Poonkuzhali Balasubramanian, Ph.D, Vikram Mathews, MD

Blood (2013) 122 (21): 1455.

https://doi.org/10.1182/blood.V122.21.1455.1455

Published: 2013

Journal Articles

Myeloid Derived Suppressor Cells in Acute Leukemia and Its Association with Conventional Cytogenetic and Molecular Risk Factors

Ansu Abu Alex, MSc, Eric Tartour, Alain Gey, Poonkuzhali Balasubramanian, Ph.D, Vivi Srivastava, MD, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 1446.

https://doi.org/10.1182/blood.V120.21.1446.1446

Published: 2012

Journal Articles

Clinical, Cellular and Molecular Differences Between Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia: Insights Into Mechanisms of Resistance

Ezhilarasi Chendamarai, Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Vandana Kamath, MD, Sukesh C Nair, MD, Nancy Beryl Janet, MSc, Vivi M Srivastava, MD, Kavitha M Lakshmi, MSc, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 1390.

https://doi.org/10.1182/blood.V120.21.1390.1390

Published: 2012

Journal Articles

Patterns of Immune Reconstitution in Patients with Acute Promyelocytic Leukemia Treated with Single Agent Arsenic Trioxide and Its Impact On Time to Molecular Remission

Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Ezhilarasi Chendamarai, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 3552.

https://doi.org/10.1182/blood.V120.21.3552.3552

Published: 2012

Journal Articles

Community Based Evaluation of Prevalence of Inhibitors in Patients with Severe Hemophilia A in India and Their Correlation with Environmental and Genetic Factors

Sachin David, MSc, Vikram Mathews, Shashikant Apte, MD, Giridhara R Jayandharan, Ph.D, Sukesh C Nair, MD, Dolly Daniel, MD, Suresh Kumar, MSc, Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Kannan Subramanian, MD, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD

Blood (2012) 120 (21): 3380.

https://doi.org/10.1182/blood.V120.21.3380.3380

Published: 2012

Journal Articles

Mechanism of Synergy Between Bortezomib and Arsenic Trioxide in Acute Promyelocytic Leukemia and Clinical Efficacy in Relapsed Patients

Saravanan Ganesan, MSc, Ezhilarasi Chendamarai, Ansu Abu Alex, MSc, Sachin David, MSc, Giridhara R Jayandharan, Ph.D, Poonkuzhali Balasubramanian, Ph.D, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews

Blood (2012) 120 (21): 3607.

https://doi.org/10.1182/blood.V120.21.3607.3607

Published: 2012

Journal Articles

Role of Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Arsenic Trioxide in Frontline Therapy

Ezhilarasi Chendamarai, MSc, Poonkuzhali Balasubramanian, Ph.D, Biju George, MD, Kavitha M Lakshmi, MSc, Auro Viswabandhya, Aby Abraham, MD, Rayaz Ahmed, MD, Ansu Abu Alex, MSc, Saravanan Ganesan, MSc, Mammen Chandy, MD, Alok Srivastava, MD, Vikram Mathews, MD

Blood (2011) 118 (21): 941.

https://doi.org/10.1182/blood.V118.21.941.941

Published: 2011

Journal Articles

Rationale and Efficacy of Bortezomib in the Treatment of Acute Promyelocytic Leukemia in Combination with Arsenic Trioxide: In-Vitro and Phase I Data

Saravanan Ganesan, MSc, Ezhilarasi Chendamarai, MSc, Jayandharan G Rao, PhD, Sangeetha Hareendran, MSc, Ansu Abu Alex, MSc, Rayaz Ahmed, MD, Aby Abraham, MD, Auro Viswabandhya, Biju George, MD, Alok Srivastava, MD, Vikram Mathews, MD

Blood (2011) 118 (21): 947.

https://doi.org/10.1182/blood.V118.21.947.947

Published: 2011

NARROW

Bone Marrow Stromal Cell Mediated Drug Resistance in AML Cells: Role of Extracellular Vesicles and AKT Signaling

Stromal-Cells Downregulate MiR-23a-5p Levels in Myeloid Leukemic Cells to Activate Protective-Autophagy Against Chemotherapeutic Agents

Fate of Ikaros in Multiple Myeloma Cells upon Treatment with Lenalidomide and Proteasome Inhibitor

Metabolic Rewiring Drives Resistance to Arsenic Trioxide in Acute Promyelocytic Leukemia

Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells

Role of miRNA in Micro-Environment Mediated Drug Resistance in Acute Promyelocytic Leukemia to Arsenic Trioxide

Management of Relapsed Acute Promyelocytic Leukemia Post ATO Upfront Therapy: Open-Labeled Phase II Study Evaluating Role of Proteasome Inhibition

Arsenic Trioxide Resistance: More to It Than Mutations in PML-RARα

The Addition of Meloxicam to G-CSF Is Associated with Good Mobilization Rates, Faster Engraftment and Reduced Toxicity and Hospital Stay after Autologous Stem Cell Transplantation – a Phase II Study

Proteasome Activity Is Dispensable for the Degradation of PML-RARα: Efficacy of Bortezomib Along with Arsenic Trioxide in the Treatment of Arsenic Sensitive and Resistant Acute Promyelocytic Leukemia

NK Cell Mediated Cytotoxicity Against Malignant Promyelocytes Enhanced By Arsenic Trioxide: Potential Clinical Relevance

Myeloid Derived Suppressor Cells in Acute Leukemia and Its Association with Conventional Cytogenetic and Molecular Risk Factors

Clinical, Cellular and Molecular Differences Between Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia: Insights Into Mechanisms of Resistance

Patterns of Immune Reconstitution in Patients with Acute Promyelocytic Leukemia Treated with Single Agent Arsenic Trioxide and Its Impact On Time to Molecular Remission

Community Based Evaluation of Prevalence of Inhibitors in Patients with Severe Hemophilia A in India and Their Correlation with Environmental and Genetic Factors

Mechanism of Synergy Between Bortezomib and Arsenic Trioxide in Acute Promyelocytic Leukemia and Clinical Efficacy in Relapsed Patients

Role of Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia Treated with Arsenic Trioxide in Frontline Therapy

Rationale and Efficacy of Bortezomib in the Treatment of Acute Promyelocytic Leukemia in Combination with Arsenic Trioxide: In-Vitro and Phase I Data

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American Society of Hematology

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American Society of Hematology

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