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Arjan van der Flier, PhD
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Journal Articles

Mechanistic Studies of Thrombin Generation Assay to Evaluate Procoagulant Potential of Fitusiran

Sravya Kattula, PhD, Ane Salvador, PhD, Shaobin Wang, PhD, Ayman Ismail, PhD, Arjan van der Flier, PhD, Nina Leksa, PhD, Joe Salas, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6.
https://doi.org/10.1182/blood-2020-142760
Published: 2020
Journal Articles

Reducing Antithrombin in Plasma to Levels Observed in Fitusiran-Treated Patients Does Not Interfere with Coagulation Assays

Shaobin Wang, PhD, Sravya Kattula, PhD, Ayman Ismail, PhD, Nina Leksa, PhD, Arjan van Der Flier, PhD, Joe Salas, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10.
https://doi.org/10.1182/blood-2020-142724
Published: 2020
Journal Articles

Differential Efficacy of Anti-Sickling and Anti-Inflammatory Mechanisms in a Fluorescent Intravital Microscopy Dorsal Skinfold Vaso-Occlusion Model in Sickle Cell Disease Townes Mice

Sarah Sturtevant, BSc, Alejandra Macias-Garcia, PhD, Sriram Krishnamoorthy, PhD, Arjan van der Flier, PhD, Alexandra Hicks, PhD, Melanie Demers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2264.
https://doi.org/10.1182/blood-2019-128922
Published: 2019
Journal Articles

A Novel Humanized Hemophilia-a Mouse Model to Facilitate Preclinical In Vivo Studies of Human Specific Fviiia-Mimetic Bispecific Antibodies

Wenjing Li, Jianxin Hu, PhD, Nina Leksa, PhD, Maria M Aleman, PhD, Robert Peters, PhD, Joe Salas, PhD, Arjan Van Der Flier, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2458.
https://doi.org/10.1182/blood-2018-99-119012
Published: 2018
Journal Articles

Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice

Joe Salas, PhD, Arjan Van Der Flier, PhD, Vu P. Hong, PhD, Jennifer Dumont, PhD, Kelly D Orcutt, PhD, Apollina Goel, PhD, Robert Peters, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1061.
https://doi.org/10.1182/blood.V130.Suppl_1.1061.1061
Published: 2017
Journal Articles

Evaluation of Recombinant Fixfc-Xten Bleeding Efficacy in Hemophilia-B Mouse Models

Zhan Liu, MSc, Arjan van der Flier, PhD, Ayman Ismail, PhD, Allison Simpson, Lutfiye Kurt, Volker Schellenberger, PhD, Christine Loh, PhD, Robert Peters, PhD
Journal: Blood
Blood (2016) 128 (22): 3757.
https://doi.org/10.1182/blood.V128.22.3757.3757
Published: 2016
Journal Articles

Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten

Zhiqian Lucy Liu, PhD, Arjan van der Flier, PhD, Sara Bardan, Sheng Ding, Volker Schellenberger, PhD, John Kulman, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2280.
https://doi.org/10.1182/blood.V126.23.2280.2280
Published: 2015
Journal Articles

Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model

Arjan van der Flier, PhD, Zhiqian Lucy Liu, PhD, Zhan Liu, MSc, Oblaise Mercury, BS, Ayman Ismail, PhD, Ekta Seth-Chhabra, PhD, John Kulman, PhD, Volker Schellenberger, PhD, David R. Light, PhD, Robert Peters, PhD
Journal: Blood
Blood (2015) 126 (23): 2271.
https://doi.org/10.1182/blood.V126.23.2271.2271
Published: 2015
Journal Articles

Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and Is a Potential Therapy for Sickle Cell Disease

Patrick C. Hines, MD PhD, Sriram Krishnamoorthy, PhD, Jennell White, PhD, Dipti Gupta, MS, Arjan van der Flier, PhD, Moira M. Lancelot, MD, Robert T. Peters, PhD BS, Haiyan Jiang, PhD, William E Hobbs, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2014) 124 (21): 221.
https://doi.org/10.1182/blood.V124.21.221.221
Published: 2014
Journal Articles

Immunohistochemical Staining of rFVIIIFc and rFVIII in Liver Cells Differentiates Between a VWF-Dependent and Independent Clearance Pathway in Mice

Arjan van der Flier, PhD, Zhan Liu, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2013) 122 (21): 2331.
https://doi.org/10.1182/blood.V122.21.2331.2331
Published: 2013
Journal Articles

Cellular Uptake of rFVIIIFc in Liver Is Primarily Contributed by Sinusoidal Endothelial Cells.

Siyuan Tan, PhD, Kai Chen, Arjan van der Flier, PhD, Zhan Liu, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2012) 120 (21): 2219.
https://doi.org/10.1182/blood.V120.21.2219.2219
Published: 2012
Journal Articles

Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc

Arjan van der Flier, PhD, Zhan Liu, Douglas Drager, Sebastien Vallee, PhD, Kai Chen, Siyuan Tan, PhD, Keith Wharton, MD, PhD, David R. Light, PhD, Haiyan Jiang, PhD
Journal: Blood
Blood (2012) 120 (21): 1103.
https://doi.org/10.1182/blood.V120.21.1103.1103
Published: 2012