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Journal Articles

The Impact of Hematopoietic Cell Transplantation on Survival: An Exploratory Analysis of a Phase 3 Study of CPX-351 Versus 7+3 in Older Patients with Newly Diagnosed, High-Risk/Secondary AML

Tara L Lin, MD, Jorge E. Cortes, MD, Laura F. Newell, MD, Ellen K. Ritchie, MD, Robert K. Stuart, MD, Stephen A. Strickland, MD, Donna Hogge, Scott R Solomon, MD, Richard M. Stone, MD, Dale L. Bixby, MD PhD, Jonathan E. Kolitz, MD, Gary J. Schiller, MD, Matthew J. Wieduwilt, MD PhD, Daniel H. Ryan, Robert Ryan, Michael Chiarella, Arthur C. Louie, Geoffrey L. Uy, MD

Blood (2018) 132 (Supplement 1): 2706.

https://doi.org/10.1182/blood-2018-99-112557

Published: 2018

Journal Articles

Efficacy and Safety of CPX-351 Versus 7+3 in a Subgroup of Older Patients with Newly Diagnosed Acute Myeloid Leukemia with Myelodysplasia-Related Changes (AML-MRC) Enrolled in a Phase 3 Study

Daniel H. Ryan, Geoffrey L. Uy, MD, Jorge E. Cortes, MD, Laura F. Newell, MD, Ellen K. Ritchie, MD, Robert K. Stuart, MD, Stephen A. Strickland, MD, Donna Hogge, Scott R Solomon, MD, Richard M. Stone, MD, Dale L. Bixby, MD PhD, Jonathan E. Kolitz, MD, Gary J. Schiller, MD, Matthew J. Wieduwilt, MD PhD, Robert Ryan, Michael Chiarella, Arthur C. Louie, Jeffrey E. Lancet, MD

Blood (2018) 132 (Supplement 1): 1425.

https://doi.org/10.1182/blood-2018-99-111514

Published: 2018

Journal Articles

Final Safety and Efficacy Results from the CPX-351 Early Access Program (EAP) for Older Patients with High-Risk/Secondary Acute Myeloid Leukemia (sAML)

Gail J. Roboz, MD, Melissa L. Larson, MD, S. Eric Rubenstein, MD, Scott R Solomon, MD, Gary J. Schiller, MD, Qi An, Emaryn Mancino, Michael Chiarella, Arthur C. Louie, Tara L Lin, MD

Blood (2018) 132 (Supplement 1): 1434.

https://doi.org/10.1182/blood-2018-99-111537

Published: 2018

Journal Articles

Efficacy and Safety of CPX-351 Versus 7+3 in Older Adults with Secondary Acute Myeloid Leukemia: Combined Subgroup Analysis of Phase 2 and Phase 3 Studies

Blood (2017) 130 (Supplement 1): 2657.

https://doi.org/10.1182/blood.V130.Suppl_1.2657.2657

Published: 2017

Journal Articles

Multivariate Efficacy Analysis of a Randomized, Phase 3 Study of CPX-351 Versus 7+3 in Older Adults with Treatment-Related Acute Myeloid Leukemia (AML) or AML with Myelodysplasia-Related Changes

Geoffrey L. Uy, MD, Jeffrey E. Lancet, MD, Jorge E. Cortes, MD, Laura F. Newell, MD, Tara L. Lin, MD, Ellen K Ritchie, MD, Robert K. Stuart, MD, Stephen A Strickland, Donna Hogge, Scott R Solomon, MD, Richard M. Stone, MD, Dale L. Bixby, Jonathan E. Kolitz, MD, Gary J. Schiller, Matthew J. Wieduwilt, Lynn Shemanski, Michael Chiarella, Arthur C Louie, Bruno C Medeiros, MD

Blood (2017) 130 (Supplement 1): 2647.

https://doi.org/10.1182/blood.V130.Suppl_1.2647.2647

Published: 2017

Journal Articles

Cost-Effectiveness of CPX-351 Versus 7+3 Regimen in the Treatment of Treatment-Related Acute Myeloid Leukemia (tAML) or AML with Myelodysplasia-Related Changes (MRC)

Anuraag Kansal, Mark Du, Oscar Herrera-Restrepo, Robert Leipold, Robert J. Ryan, Arthur C. Louie, Karen Chung

Blood (2017) 130 (Supplement 1): 4674.

https://doi.org/10.1182/blood.V130.Suppl_1.4674.4674

Published: 2017

Journal Articles

Subanalysis of Patients with Secondary Acute Myeloid Leukemia (sAML) with Refractory Anemia with Excess of Blasts in Transformation (RAEB-t) Enrolled in a Phase 3 Study of CPX-351 Versus Conventional 7+3 Cytarabine and Daunorubicin

Tara L. Lin, MD, Geoffrey L. Uy, MD, Matthew J. Wieduwilt, Laura F. Newell, MD, Robert K. Stuart, MD, Bruno C Medeiros, MD, Gary J. Schiller, Eric Rubenstein, MD, Wendy Stock, MD, Erica D. Warlick, MD, Matthew Foster, Dale L. Bixby, Nikolai A. Podoltsev, MD PhD, Qi An, Stefan Faderl, Arthur C. Louie, Jeffrey E. Lancet, MD

Blood (2017) 130 (Supplement 1): 1698.

https://doi.org/10.1182/blood.V130.Suppl_1.1698.1698

Published: 2017

Journal Articles

Rates of Adverse Events per Patient-Year in a Randomized, Phase 3 Study of CPX-351 Versus 7+3 in Older Adults with Newly Diagnosed, Treatment-Related Acute Myeloid Leukemia (AML) or AML with Myelodysplasia-Related Changes

Bruno C Medeiros, MD, Jeffrey E. Lancet, MD, Jorge E. Cortes, MD, Laura F. Newell, MD, Tara L. Lin, MD, Ellen K Ritchie, MD, Robert K. Stuart, MD, Stephen A. Strickland, MD MSCI, Donna Hogge, Scott R Solomon, MD, Richard M. Stone, MD, Dale L. Bixby, Jonathan E. Kolitz, MD, Gary J. Schiller, Matthew J. Wieduwilt, Robert J. Ryan, Michael Chiarella, Arthur C Louie, Geoffrey L. Uy, MD

Blood (2017) 130 (Supplement 1): 1366.

https://doi.org/10.1182/blood.V130.Suppl_1.1366.1366

Published: 2017

Journal Articles

Randomized Study of CPX-351 for Medically Less-Fit Adults with Newly Diagnosed Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasm

Roland B. Walter, MD PhD MS, Megan Othus, PhD, Kaysey F. Orlowski, Emily N. McDaniel, Bart L. Scott, MD, Pamela S. Becker, MD PhD, Mary-Elizabeth M. Percival, MD MS, Paul C. Hendrie, MD PhD, Bruno C Medeiros, MD, Michael T. Chiarella, Arthur C. Louie, Elihu H. Estey, MD

Blood (2017) 130 (Supplement 1): 1346.

https://doi.org/10.1182/blood.V130.Suppl_1.1346.1346

Published: 2017

Journal Articles

Survival Following Allogeneic Hematopoietic Cell Transplantation in Older High-Risk Acute Myeloid Leukemia Patients Initially Treated with CPX-351 Liposome Injection Versus Standard Cytarabine and Daunorubicin: Subgroup Analysis of a Large Phase III Trial

Blood (2016) 128 (22): 906.

https://doi.org/10.1182/blood.V128.22.906.906

Published: 2016

Journal Articles

Burden of Acute Myeloid Leukemia (AML) Among Older Newly-Diagnosed Patients

Naomi C. Sacks, PhD, Phil Cyr, MPH, Yanmei Liu, MS, Derek J. Miller, MBA, Michael T. Chiarella, Arthur C. Louie, MD

Blood (2016) 128 (22): 4780.

https://doi.org/10.1182/blood.V128.22.4780.4780

Published: 2016

Journal Articles

Analysis of Efficacy By Age for Patients Aged 60-75 with Untreated Secondary Acute Myeloid Leukemia (AML) Treated with CPX-351 Liposome Injection Versus Conventional Cytarabine and Daunorubicin in a Phase III Trial

Blood (2016) 128 (22): 902.

https://doi.org/10.1182/blood.V128.22.902.902

Published: 2016

Journal Articles

Enhanced Cytarabine and Daunorubicin Population Pharmacokinetics When Administered As CPX-351: A Novel Liposomal Formulation Not Requiring Dose Reduction for Mild Renal or Hepatic Dysfunction

Mina Nikanjam, MD PhD, Edmund Capparelli, PharmD, Jeffrey E. Lancet, MD, Jonathan E. Kolitz, MD, Arthur C. Louie, MD, Gary J. Schiller, MD

Blood (2016) 128 (22): 3955.

https://doi.org/10.1182/blood.V128.22.3955.3955

Published: 2016

Journal Articles

CPX-351 ((Cytarabine:Daunorubicin) Liposome Injection, (Vyxeos)) Does Not Prolong Qtcf Intervals, Requires No Dose Adjustment for Impaired Renal Function and Induces High Rates of Complete Remission in Acute Myeloid Leukemia

Tara L. Lin, MD, Laura F. Newell, MD, Robert K. Stuart, MD, Laura C. Michaelis, MD, Stephen E. Rubenstein, MD, Helen S. Pentikis, PhD, Timothy Callahan, PhD, Donna Alvarez, Lawrence D. Mayer, PhD, Arthur C. Louie, MD

Blood (2015) 126 (23): 2510.

https://doi.org/10.1182/blood.V126.23.2510.2510

Published: 2015

Journal Articles

CPX-351 Enables Administration of Consolidation Treatment in the Outpatient Setting and Increases the Time Spent out of the Hospital after Completion of AML Treatment Compared with 7+3

Jeffrey E Lancet, MD, Phillip Cyr, MPH, Naomi Sacks, PhD, Michael T. Chiarella, Arthur C. Louie, MD, Jorge E. Cortes, MD

Blood (2015) 126 (23): 4507.

https://doi.org/10.1182/blood.V126.23.4507.4507

Published: 2015

Journal Articles

Randomized Study of Liposomal Cytarabine and Daunorubicin (CPX-351) for Adults with Untreated High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) at High Risk of Treatment-Related Mortality

Roland B. Walter, MD PhD MS, Kaysey F. Orlowski, Morgan A. Powell, BS, Pamela S. Becker, MD PhD, Paul C. Hendrie, MD PhD, Fabiana Ostronoff, MD, Elizabeth M. Ranker, PA-C, Megan Othus, PhD, Arthur C. Louie, MD, Elihu H. Estey, MD

Blood (2014) 124 (21): 994.

https://doi.org/10.1182/blood.V124.21.994.994

Published: 2014

Journal Articles

Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML

Jeffrey E. Lancet, Jorge E. Cortes, Donna E. Hogge, Martin S. Tallman, Tibor J. Kovacsovics, Lloyd E. Damon, Rami Komrokji, Scott R. Solomon, Jonathan E. Kolitz, Maureen Cooper, Andrew M. Yeager, Arthur C. Louie, Eric J. Feldman

Blood (2014) 123 (21): 3239–3246.

https://doi.org/10.1182/blood-2013-12-540971

Published: 2014

Includes: Supplemental data

Journal Articles

CPX-351 Is Effective in Newly Diagnosed Older Patients with AML and with Multiple Risk Factors

Jeffrey E Lancet, MD, Jorge E Cortes, MD, Tibor Kovacsovics, MD, Donna E. Hogge, MD, PhD, FRCPC, Jonathan E. Kolitz, MD, Martin S Tallman, MD, Antje Hoering, PhD, Michael T. Chiarella, Arthur C. Louie, MD, Eric Feldman, MD

Blood (2012) 120 (21): 3626.

https://doi.org/10.1182/blood.V120.21.3626.3626

Published: 2012

Journal Articles

Significance of Prior HSCT on the Outcome of Salvage Therapy with CPX-351 or Conventional Chemotherapy Among First Relapse AML Patients

Jorge E. Cortes, Eric J Feldman, MD, Stuart L. Goldberg, MD, David A. Rizzieri, MD, Arthur C. Louie, MD, Jonathan E. Kolitz, MD

Blood (2011) 118 (21): 2619.

https://doi.org/10.1182/blood.V118.21.2619.2619

Published: 2011

Journal Articles

CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in '65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report

Jorge E. Cortes, Eric J Feldman, MD, Stuart L. Goldberg, MD, David A. Rizzieri, MD, Kim H. Paulsen, Arthur C. Louie, MD, Jonathan E. Kolitz, MD

Blood (2011) 118 (21): 254.

https://doi.org/10.1182/blood.V118.21.254.254

Published: 2011

NARROW

The Impact of Hematopoietic Cell Transplantation on Survival: An Exploratory Analysis of a Phase 3 Study of CPX-351 Versus 7+3 in Older Patients with Newly Diagnosed, High-Risk/Secondary AML

Efficacy and Safety of CPX-351 Versus 7+3 in a Subgroup of Older Patients with Newly Diagnosed Acute Myeloid Leukemia with Myelodysplasia-Related Changes (AML-MRC) Enrolled in a Phase 3 Study

Final Safety and Efficacy Results from the CPX-351 Early Access Program (EAP) for Older Patients with High-Risk/Secondary Acute Myeloid Leukemia (sAML)

Efficacy and Safety of CPX-351 Versus 7+3 in Older Adults with Secondary Acute Myeloid Leukemia: Combined Subgroup Analysis of Phase 2 and Phase 3 Studies

Multivariate Efficacy Analysis of a Randomized, Phase 3 Study of CPX-351 Versus 7+3 in Older Adults with Treatment-Related Acute Myeloid Leukemia (AML) or AML with Myelodysplasia-Related Changes

Cost-Effectiveness of CPX-351 Versus 7+3 Regimen in the Treatment of Treatment-Related Acute Myeloid Leukemia (tAML) or AML with Myelodysplasia-Related Changes (MRC)

Subanalysis of Patients with Secondary Acute Myeloid Leukemia (sAML) with Refractory Anemia with Excess of Blasts in Transformation (RAEB-t) Enrolled in a Phase 3 Study of CPX-351 Versus Conventional 7+3 Cytarabine and Daunorubicin

Rates of Adverse Events per Patient-Year in a Randomized, Phase 3 Study of CPX-351 Versus 7+3 in Older Adults with Newly Diagnosed, Treatment-Related Acute Myeloid Leukemia (AML) or AML with Myelodysplasia-Related Changes

Randomized Study of CPX-351 for Medically Less-Fit Adults with Newly Diagnosed Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasm

Survival Following Allogeneic Hematopoietic Cell Transplantation in Older High-Risk Acute Myeloid Leukemia Patients Initially Treated with CPX-351 Liposome Injection Versus Standard Cytarabine and Daunorubicin: Subgroup Analysis of a Large Phase III Trial

Burden of Acute Myeloid Leukemia (AML) Among Older Newly-Diagnosed Patients

Analysis of Efficacy By Age for Patients Aged 60-75 with Untreated Secondary Acute Myeloid Leukemia (AML) Treated with CPX-351 Liposome Injection Versus Conventional Cytarabine and Daunorubicin in a Phase III Trial

Enhanced Cytarabine and Daunorubicin Population Pharmacokinetics When Administered As CPX-351: A Novel Liposomal Formulation Not Requiring Dose Reduction for Mild Renal or Hepatic Dysfunction

CPX-351 ((Cytarabine:Daunorubicin) Liposome Injection, (Vyxeos)) Does Not Prolong Qtcf Intervals, Requires No Dose Adjustment for Impaired Renal Function and Induces High Rates of Complete Remission in Acute Myeloid Leukemia

CPX-351 Enables Administration of Consolidation Treatment in the Outpatient Setting and Increases the Time Spent out of the Hospital after Completion of AML Treatment Compared with 7+3

Randomized Study of Liposomal Cytarabine and Daunorubicin (CPX-351) for Adults with Untreated High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) at High Risk of Treatment-Related Mortality

Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML

CPX-351 Is Effective in Newly Diagnosed Older Patients with AML and with Multiple Risk Factors

Significance of Prior HSCT on the Outcome of Salvage Therapy with CPX-351 or Conventional Chemotherapy Among First Relapse AML Patients

CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in '65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report

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American Society of Hematology

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American Society of Hematology

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