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Aymee Perez, PhD
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Journal Articles

The Lysine-Specific Demethylase 1 (LSD1) Inhibitor Tranylcypromine (TCP) in Combination with ATRA Is Tolerable and Has Anti-Leukemic Activity in Adult Patients with Relapsed/Refractory AML and MDS

Justin M Watts, MD, Terrence J Bradley, MD, Amber Thomassen, MA, MSN, Yvonne Trang Dinh, BS, Dalissa Tejera, MSN, Kristen Englund, Sorab Boga, MPH, Randy Astaiza, BS, Charles J Chen, MPH, Malika Abdur-Rahman, BS, MSED, Marinescu Ion, CCRC, FMG, Aymee Perez, PhD, Masoumeh Tayari, PhD, Lluis Morey, PhD, Maria E. Figueroa, MD, Ramin Shiekhattar, PhD, Arthur Zelent, PhD, Ronan Swords, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2721.
https://doi.org/10.1182/blood-2018-99-115411
Published: 2018
Journal Articles

The Novel Translocation t(4;15)(q31;q22) in AML Is Associated with a Proliferative Phenotype in the Presence of All-Trans Retinoic Acid (ATRA)

Justin M Watts, MD, Aymee Perez, PhD, Fernando Vargas, MD, Yao-Shan Fan, MD PhD, Alejandra Weisman, Ana Rodriguez, Omar Lopez, Francisco Vega, MD PhD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD
Journal: Blood
Blood (2016) 128 (22): 1526.
https://doi.org/10.1182/blood.V128.22.1526.1526
Published: 2016
Journal Articles

The BET Bromodomain Inhibitors EP11313 and EP11336 Have Potent Anti-Leukemic Activity in Acute Myeloid Leukemia (AML) and Augment the Effects of All-Trans-Retinoic Acid (AtRA) in Vitro

Ronan T. Swords, MDPhDFRCPI FRCPath, Shaun Brothers, PhD, Nagi Ayad, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Ana Rodriguez, Shawn Johnstone, PhD, Jeffrey Albert, Joseph Collard, Arthur Zelent, PhD, Claes Wahlestedt, PhD
Journal: Blood
Blood (2015) 126 (23): 2552.
https://doi.org/10.1182/blood.V126.23.2552.2552
Published: 2015
Journal Articles

A Patient-Specific Ex Vivo Screening Platform for Personalized Acute Myeloid Leukemia (AML) Therapy

Diana Azzam, PhD, Claude-Henry Volmar, PhD, Al-Ali Hassan, PhD, Aymee Perez, PhD, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Francisco Vega, MD PhD, Arthur Zelent, PhD, Christopher R. Cogle, MD, Claes Wahlestedt, PhD, Ronan T. Swords, MDPhDFRCPI FRCPath
Journal: Blood
Blood (2015) 126 (23): 1352.
https://doi.org/10.1182/blood.V126.23.1352.1352
Published: 2015
Journal Articles

Inhibition of the PI3K/AKT/mTOR Pathway Leads to Down-Regulation of c-Myc and Overcomes Resistance to ATRA in Acute Myeloid Leukemia

Ronan T. Swords, MDPhDFRCPI FRCPath, Tino Schenk, PhD, Sven Stengel, PhD, Veronica Sylvina Gil, PhD, Kevin R. Petrie, PhD, Aymee Perez, PhD, Rodriguez Ana, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 1363.
https://doi.org/10.1182/blood.V126.23.1363.1363
Published: 2015
Journal Articles

The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Fernando Vargas, MD, Roy Elias, Hugh Y. Rienhoff, Jr., MD, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 460.
https://doi.org/10.1182/blood.V126.23.460.460
Published: 2015
Journal Articles

In Acute Myeloid Leukemia (AML), Targeting the Histone Methyltransferase EZH2 Promotes Differentiation, Impairs Clonogenic Survival and Augments the Anti-Leukemic Effects of the Retinoid, All-Trans-Retinoic Acid (ATRA)

Ronan T. Swords, MDPhDFRCPI FRCPath, Aymee Perez, PhD, Ana Rodriguez, Justin M. Watts, MD, Tino Schenk, PhD, Fernando Vargas, MD, Roy Elias, Arthur Zelent, PhD
Journal: Blood
Blood (2015) 126 (23): 3786.
https://doi.org/10.1182/blood.V126.23.3786.3786
Published: 2015
Journal Articles

Sodium Salicylate Has a Priming Effect When Combined with Azacitidine in Pre-Clinical Models of AML

Yehuda E. Deutsch, MD, Aymee Perez, PhD, Ana Rodrigues, BS, Ezra S. Blumenthal, Elena Cubedo, PhD, Justin M. Watts, MD, Ronan T Swords, MD PhD FRCPI, FRCPath, Arthur Zelent, PhD
Journal: Blood
Blood (2014) 124 (21): 2300.
https://doi.org/10.1182/blood.V124.21.2300.2300
Published: 2014