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Journal Articles

Rare Germline Variant in NFATC4 Associated with Familial Chronic Lymphocytic Leukemia

Gilad Itchaki, Grace Tiao, PhD, Ma Reina D. Improgo, PhD, Siddha Kasar, PhD, Bethany Tesar, MS, Stacey Marie Fernandes, BS, Nathalie Pochet, PhD, Emily M McWilliams, PhD, Harrison Bai, Arnold S. Freedman, MD, Gad Getz, PhD, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2993.
https://doi.org/10.1182/blood.V130.Suppl_1.2993.2993
Published: 2017
Journal Articles

MYD88 L265P Mutations Influence Clinical Outcome and Identify a Pathway for Targeted Inhibition in Chronic Lymphocytic Leukemia

Bethany Tesar, MS, Reina Improgo, PhD, Josephine L. Klitgaard, MSc,PhD, Reuma Magori-Cohen, Lijian Yu, Divya Chaudhary, Wenyan Miao, Stacey M. Fernandes, Kevin Hoang, William F Westlin, Haesook T. Kim, PhD, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2015) 126 (23): 491.
https://doi.org/10.1182/blood.V126.23.491.491
Published: 2015
Journal Articles

Inhibition of the Notch1 Pathway in Chronic Lymphocytic Leukemia Promotes Apoptosis and Inhibits Proliferation

Josephine L. Klitgaard, MSc,PhD, Reuma Magori-Cohen, PhD, Reina Improgo, PhD, Stacey M. Fernandes, Bethany Tesar, Kevin Hoang, Haesook T Kim, PhD, Jennifer R. Brown, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1972.
https://doi.org/10.1182/blood.V124.21.1972.1972
Published: 2014
Journal Articles

Effect Of MYD88 Mutation In CLL On IRAK4 and BTK Inhibition In Vitro

Bethany Tesar, Divya Chaudhary, Lillian Werner, Reina Improgo, Nathalie Pochet, Stacey M Fernandes, Kevin Hoang, Alexander R. Vartanov, Donna L. Romero, Shaughnessy D. Robinson, Donna S. Neuberg, ScD, William F. Westlin, Jennifer R. Brown, M.D.
Journal: Blood
Blood (2013) 122 (21): 4132.
https://doi.org/10.1182/blood.V122.21.4132.4132
Published: 2013
Journal Articles

NF-κB Pathway Mutations Modulate Cell Survival and Ibrutinib Response In Chronic Lymphocytic Leukemia

Reina Improgo, Grace Tiao, Adam Kiezun, Yaoyu Wang, Lillian Werner, Carrie Sougnez, Bethany Tesar, Stacey M Fernandes, Alexander R. Vartanov, Kevin Hoang, Donna S. Neuberg, ScD, Gad Getz, Jennifer R. Brown, M.D.
Journal: Blood
Blood (2013) 122 (21): 670.
https://doi.org/10.1182/blood.V122.21.670.670
Published: 2013
Journal Articles

Risk Alleles Identified in Genome-Wide Association Studies Are Associated with Expression Quantitative Trait Loci in Chronic Lymphocytic Leukemia.

Bethany Tesar, Lillian Werner, Megan Hanna, Ma Reina Improgo, Nathalie Pochet, Stacey M. Fernandes, Laura Macconaill, Ph.D., Aviv Regev, PhD, Arnold S. Freedman, M.D., Donna S. Neuberg, ScD, Matthew L. Freedman, M.D., Jennifer R. Brown, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2875.
https://doi.org/10.1182/blood.V120.21.2875.2875
Published: 2012
Journal Articles

Somatic and Germline Copy Neutral Loss of Heterozygosity Are Common in Chronic Lymphocytic Leukemia

Megan Hanna, Bethany Tesar, Kristen E. Stevenson, MS, Alexander R. Vartanov, BS, Stacey M. Fernandes, Laura Macconaill, Ph.D., Dan-Avi Landau, M.D., Catherine J. Wu, MD, Donna S. Neuberg, ScD, Arnold S. Freedman, M.D., Jennifer R. Brown, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4567.
https://doi.org/10.1182/blood.V120.21.4567.4567
Published: 2012
Journal Articles

The Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Dan-Avi Landau, MD, Scott Carter, Petar Stojanov, Kristen E. Stevenson, MS, Aaron Mckenna, PhD, Michael Lawrence, Ph.D., Carrie Sougnez, Andrey Sivachenko, Lili Wang, M.D., Ph.D., Wandi Zhang, Shukla Sachet, Alexander R. Vartanov, BS, Stacey M. Fernandes, Kristian Cibulskis, Bethany Tesar, Stacey Gabriel, Matthew Meyerson, Eric S. Lander, PhD, Donna S. Neuberg, ScD, Jennifer R. Brown, MD, PhD, Gad Getz, Ph.D., Catherine J. Wu, MD
Journal: Blood
Blood (2012) 120 (21): 5.
https://doi.org/10.1182/blood.V120.21.5.5
Published: 2012
Journal Articles

Functional Somatic and Germline Variants in the NF-κB Pathway in Chronic Lymphocytic Leukemia

Ma. Reina Improgo, Adam Kiezun, Yaoyu Wang, Lillian Werner, Petar Stojanov, Dan Landau, M.D., Carrie Sougnez, Bethany Tesar, Stacey M. Fernandes, Alexander R. Vartanov, BS, Michael S. Lawrence, Kristian Cibulskis, Donna S. Neuberg, ScD, Catherine J. Wu, MD, Gad Getz, Ph.D., Jennifer R. Brown, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 560.
https://doi.org/10.1182/blood.V120.21.560.560
Published: 2012
Journal Articles

Clinical Development of AVL-292; A Potent, Selective Covalent Btk Inhibitor for the Treatment of B Cell Malignancies,

Erica Evans, PhD, Richland Tester, PhD, Sharon Aslanian, Prasoon Chaturvedi, PhD, Hormoz Mazdiyasni, Sabine Ponader, PhD, Bethany Tesar, Michael Sheets, Mariana Nacht, PhD, Kathryn Stiede, Steve Witowski, PhD, Heather Lounsbury, Russell Petter, PhD, Jennifer R. Brown, MD, PhD, Jan A. Burger, MD, PhD, Juswinder Singh, PhD, William F. Westlin, PhD
Journal: Blood
Blood (2011) 118 (21): 3485.
https://doi.org/10.1182/blood.V118.21.3485.3485
Published: 2011
Journal Articles

Obatoclax in Combination with Fludarabine and Rituximab (FR) Is Well-Tolerated and Shows Promising Clinical Activity in Relapsed CLL/SLL

Jennifer R Brown, MD, PhD, Bethany Tesar, Lillian Werner, Evgeny Mikler, Hazel Reynolds, Christina Thompson, David C. Fisher, MD, Naoko Takebe, MD, PhD, Donna Neuberg, ScD, Arnold S. Freedman, MD
Journal: Blood
Blood (2011) 118 (21): 2865.
https://doi.org/10.1182/blood.V118.21.2865.2865
Published: 2011
Journal Articles

Large-Scale CLL Genome Analysis Reveals Novel Cancer Genes, Including SF3B1

Youzhong Wan, Michael S Lawrence, Lili Wang, Petar Stojanov, Carrie Sougnez, Kristen Stevenson, M.S., Lillian Werner, MS, Wandi Zhang, Eric G Folco, Bethany Tesar, Quinlan L Sievers, Stacey Gabriel, Nir Hacohen, Robin Reed, Matthew Meyerson, Todd R. Golub, MD, Eric S Lander, Donna Neuberg, ScD, Jennifer R. Brown, MD, PhD, Gad Getz, Catherine J Wu, MD
Journal: Blood
Blood (2011) 118 (21): 463.
https://doi.org/10.1182/blood.V118.21.463.463
Published: 2011
Journal Articles

Novel Germline Genetic Variants Associated with Familial Chronic Lymphocytic Leukemia (CLL)

Jennifer R Brown, MD, PhD, Michael S Lawrence, Megan Hanna, Bethany Tesar, Petar Stojanov, Alexander R. Vartanov, Stacey M Fernandes, Carrie Sougnez, Laura MacConaill, Nathalie Pochet, Aviv Regev, PhD, Lillian Werner, Stacey Gabriel, Eric S Lander, Donna Neuberg, ScD, Arnold S. Freedman, MD, Gad Getz, Catherine J Wu, MD
Journal: Blood
Blood (2011) 118 (21): 465.
https://doi.org/10.1182/blood.V118.21.465.465
Published: 2011
Journal Articles

A Phase I Study of Escalated Dose Subcutaneous Alemtuzumab Given Weekly with Rituximab In Relapsed CLL/SLL.

Jennifer R Brown, MD, PhD, Bradley Messmer, Lillian Werner, Evgeny Mikler, David C. Fisher, MD, Ann LaCasce, MD, MSc, Philippe Armand, MD, PhD, Eric D Jacobsen, MD, Virginia Dalton, Bethany Tesar, Stacey M Fernandes, Sean McDonough, MS, Jerome Ritz, MD, Laura Z Rassenti, PhD, Thomas J. Kipps, MD, PhD, Donna Neuberg, ScD, Arnold S. Freedman, MD
Journal: Blood
Blood (2010) 116 (21): 1381.
https://doi.org/10.1182/blood.V116.21.1381.1381
Published: 2010
Journal Articles

High Resolution Genomic Analysis In CLL Demonstrates Genomic Stability In Untreated Patients and Novel Markers of Progression In Treated Patients

Jennifer R Brown, MD, PhD, Megan Hanna, Bethany Tesar, Lillian Werner, Hazel Reynolds, Stacey M Fernandes, Laura Macconaill, Yaoyu Wang, Mick Correll, Donna Neuberg, ScD, Arnold S. Freedman, MD
Journal: Blood
Blood (2010) 116 (21): 2426.
https://doi.org/10.1182/blood.V116.21.2426.2426
Published: 2010
Journal Articles

Amplification of 6p Associated with Familial CLL

Jennifer R Brown, MD, PhD, Bethany Tesar, Megan Hanna, Megan Ash, Stacey M Fernandes, Laura Macconaill, Ursula Hainz, Janina Longtine, Catherine J Wu, MD, Lillian Werner, Yaoyu Wang, Mick Correll, Donna Neuberg, ScD, Arnold S. Freedman, MD
Journal: Blood
Blood (2010) 116 (21): 2432.
https://doi.org/10.1182/blood.V116.21.2432.2432
Published: 2010