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Journal Articles

The Pyruvate Kinase Activator Mitapivat Ameliorates Anemia and Prevents Iron Overload in a Mouse Model of Hereditary Spherocytosis

Alessandro Mattè, BSc,PhD, Wilson Anand, Enrica Federti, PhD, Charles Kung, PhD, Penelope A. Kosinski, MS, Veronica Riccardi, Iana Iatcenko, Lenny Dang, PhD, Christophe Leboeuf, Anne Janin, PhD, Carlo Brugnara, MD, Mohandas Narla, DSc, Lucia De Franceschi, MD

Blood (2020) 136 (Supplement 1): 29.

https://doi.org/10.1182/blood-2020-142232

Published: 2020

Journal Articles

Measuring Reticulocyte Hemoglobin Content As a Marker for Iron Deficiency and Response to Therapy Represents a Paradigm Shift in Care

Michael Auerbach, MD, Carlo Brugnara, MD, Steve Staffa, PhD

Blood (2020) 136 (Supplement 1): 42–43.

https://doi.org/10.1182/blood-2020-134693

Published: 2020

Journal Articles

Dietary Omega-3 Fatty Acid Supplementation Improves Sickle Cell Bone Disease By Affecting Osteoblastogenesis and Adipogenesis

Maria Teresa Valenti, PhD, Luca Dalle Carbonare, MD, Alessandro Mattè, BSc, PhD, Lorenzo Anez-Bustillos, Mark Puder, MD, Samuele Cheri, Michela Deiana, Enrica Federti, PhD, Serge Cedrick Toya Mbiandjeu, Angela Siciliano, Carlo Brugnara, MD, Lucia De Franceschi, MD

Blood (2018) 132 (Supplement 1): 2356.

https://doi.org/10.1182/blood-2018-99-115801

Published: 2018

Journal Articles

Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease

Tolulope O Rosanwo, BA, Melissa Kinney, PhD, Martha A Clark, PhD, Linda T Vo, PhD, R. Grant Rowe, MD PhD, Natasha M. Archer, MD, Matthew M Heeney, MD, Thorsten Schlaeger, PhD, Daniel E. Bauer, MD PhD, Mark D. Fleming, MD DPhil, Manoj T Duraisingh, PhD, Stuart H. Orkin, MD, Carlo Brugnara, MD, Trista North, PhD, George Q. Daley, MD PhD

Blood (2018) 132 (Supplement 1): 2359.

https://doi.org/10.1182/blood-2018-99-114136

Published: 2018

Journal Articles

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Blood (2018) 132 (Supplement 1): 3482.

https://doi.org/10.1182/blood-2018-99-119365

Published: 2018

Journal Articles

Imatinib Protects Against Hypoxia/Reoxygenation Induced Lung and Kidney Injury in a Humanized Mouse Model for SCD

Alessandro Mattè, BSc,PhD, Enrica Federti, PhD, Antonio Rechiutti, Amtonella Panataleo, Roberta Russo, Francesco Turrini, MD PhD, Angela Siciliano, Pierre Louis Tharaux, MD PhD, Wassim El Nemer, PhD, Serge Cedrick, Anne Janin, PhD, Christophe Leboeuf, Wilson Babu, Achille Iolascon, MD PhD, Carlo Brugnara, MD, Lucia De Franceschi, MD

Blood (2018) 132 (Supplement 1): 725.

https://doi.org/10.1182/blood-2018-99-115832

Published: 2018

Journal Articles

Acoustic Levitation: A Novel Approach to Study the Physical Properties of Blood in Normal Subjects and in Patients with Sickle Cell Disease

Vahideh Ansari Hosseinzadeh, Carlo Brugnara, MD, R. Glynn Holt

Blood (2017) 130 (Supplement 1): 4776.

https://doi.org/10.1182/blood.V130.Suppl_1.4776.4776

Published: 2017

Journal Articles

A Selective ORAL GLYT1 Inhibitor, Improves Anemia and RED CELL Survival in a MOUSE MODEL of Beta-Thalassemia

Carlo Brugnara, MD, Anja Harmeier, Lucia De Franceschi, MD, Alessandro Matte, Michael Winter, Annette Koerner, Omar Khwaja, Thomas Singer, Elisabetta Beneduce, Enrica Federti, Angela Siciliano

Blood (2016) 128 (22): 1284.

https://doi.org/10.1182/blood.V128.22.1284.1284

Published: 2016

Journal Articles

Resolvin D1 and Resolvin D2 Protect Against Hypoxia/Reoxygenation Induced Lung and Kidney Damage in a Sickle Cell Mouse Model of Acute Vaso-Occlusive Crisis

Alessandro Mattè, PhD, Antonio Recchiuti, PhD, Charles Serhan, PhD, Angela Siciliano, Enrica Federti, Olga Weinberg, MD, Brian Kalish, MD, Carlo Brugnara, MD, Lucia De Franceschi, MD

Blood (2015) 126 (23): 966.

https://doi.org/10.1182/blood.V126.23.966.966

Published: 2015

Journal Articles

Dietary ω-3 Fatty Acid Supplementation As a Potential New Therapy for Vasculopathy in Sickle Cell Disease: Proof of Concept in a Transgenic Mouse Model

Brian T Kalish, MD, Alessandro Matte, PhD, Immacolata Andolfo, Achille Iolascon, Olga Weinberg, Angela Siciliano, Mrs, Enrica Federti, Mark Puder, MD PhD, Carlo Brugnara, MD, Lucia De Franceschi, MD

Blood (2014) 124 (21): 220.

https://doi.org/10.1182/blood.V124.21.220.220

Published: 2014

Journal Articles

Senicapoc, a Gardos Channel Inhibitor Developed to Treat Sickle Cell Disease, Exhibits Antimalarial Activity

Venee N. Tubman, MD MMSc, Pedro Mejia, PhD, Boris E. Shmukler, PhD, Seth L. Alper, MD PhD, James R. Mitchell, PhD, Carlo Brugnara, MD, Manoj T. Duraisingh, PhD

Blood (2014) 124 (21): 743.

https://doi.org/10.1182/blood.V124.21.743.743

Published: 2014

Journal Articles

Pharmacological Inhibition of Calpain-1 Prevents Red Cell Dehydration and Reduces Gardos Channel Activity in a Mouse Model of Sickle Cell Disease. Identification of Druggable Protease Target

Lucia De Franceschi, MD, Alessandro Mattè, PhD, Carlo Brugnara, MD, Angela Siciliano, Mariarita Bertoldi, PhD, Adam Wieschhaus, PhD, Athar H. Chishti, PhD

Blood (2011) 118 (21): 852.

https://doi.org/10.1182/blood.V118.21.852.852

Published: 2011

Journal Articles

Footprints of Response to Hydroxyurea Are in the Hemogram.

Samir K. Ballas, MD, William F. McCarthy, Ph., D., Nan Gua, Carlo Brugnara, MD, Gail M Kling, MS, Robert L Bauserman, PhD, Myron A Waclawiw, PhD

Blood (2009) 114 (22): 4619.

https://doi.org/10.1182/blood.V114.22.4619.4619

Published: 2009

Journal Articles

Effects of Hydroxyurea (HU) and Magnesium Pidolate (Mg) in Hemoglobin SC Disease (HbSC): the “CHAMPS” Trial.

Winfred C. Wang, M.D., Cathie Snyder, Carlo Brugnara, MD, Marilyn J. Telen, MD, Martin H Steinberg, MD, Lynn W Wynn, MSN, CPNP, Julie McAfee, B.S., Zora R. Rogers, MD, Karen Kalinyak, MD, Clinton H. Joiner, MD, PhD, Karen Kesler, PhD

Blood (2009) 114 (22): 819.

https://doi.org/10.1182/blood.V114.22.819.819

Published: 2009

Journal Articles

Genetic Evidence That Sequence Variation at the β-Globin Locus Underlies Differences in Cell Hemoglobin Concentration and Cell Hydration in Single ( Hbb s ) Vs. Diffuse ( Hbb d ) Inbred Mouse Strains: Implications for Inherited Anemias

Luanne L. Peters, PhD, Amy J. Lambert, BS, Shirngwern Tsaih, PhD, Jordan A. Shavit, MD, PhD, David Ginsburg, MD, Gary A. Churchill, PhD, Carlo Brugnara, MD

Blood (2008) 112 (11): 419.

https://doi.org/10.1182/blood.V112.11.419.419

Published: 2008

Journal Articles

Regulators of Erythrocyte Volume as Modifiers in Sickle Cell Disease: The Gardos Channel.

Charles Tian, Maureen Okam, MD, Seth L. Alper, MD PhD, Martin H. Steinberg, MD, Carlo Brugnara, MD, Patrick G. Gallagher, MD

Blood (2007) 110 (11): 3387.

https://doi.org/10.1182/blood.V110.11.3387.3387

Published: 2007

Journal Articles

Various Drugs with or without an Antisickling Effect in the In Vitro Tests Showed a Strong Antisickling Effect in the In Vivo Studies in Transgenic Sickle Mice.

Toshio Asakura, MD, PhD, Osheiza Abdulmalik, DVM, Efe Iyamu, PhD, Qiukan Chen, MD, Jisheng Yang, Donald J. Abraham, PhD, Martin K. Safo, PhD, Carlo Brugnara, MD, Greg Evans, PhD

Blood (2005) 106 (11): 3190.

https://doi.org/10.1182/blood.V106.11.3190.3190

Published: 2005

Journal Articles

The Safety and Efficacy of Oral Magnesium Pidolate in Children with Hemoglobin SC Disease.

Brigitta Ursula Mueller, MD, Marlen Dinu, MD, Susan Kurth, PNP, Roz Bryant, PNP, Elizabeth Mullen, MD, Yan Jinrong, Donald H. Mahoney, MD, Carlo Brugnara, MD

Blood (2005) 106 (11): 3777.

https://doi.org/10.1182/blood.V106.11.3777.3777

Published: 2005

Journal Articles

MSDD1, a Prodrug of 5-Hydroxymethyl-2-Furfural (5HMF), Prolongs the Antisickling Effect of 5HMF in Transgenic Sickle Mice.

Osheiza Abdulmalik, DVM, Martin K. Safo, PhD, Richmond Danso-Danquah, PhD, Jisheng Yang, Qiukan Chen, MD, Carlo Brugnara, MD, Donald J. Abraham, PhD, Toshio Asakura, MD, PhD

Blood (2004) 104 (11): 3576.

https://doi.org/10.1182/blood.V104.11.3576.3576

Published: 2004

Journal Articles

PDE-4 Inhibitor Rolipram Prevents Hypoxia Induced Pulmonary Hypertension in Transgenic Sickle Cell Sad Mice.

Lucia De Franceschi, MD, Giorgio Malpeli, Anne Janin, MD, Aldo Scarpa, MD, Christhophe Leboeuf, Orah Platt, MD, Philippe Leboulch, Emmanuel Payen, Yves Beuzard, MD, Carlo Brugnara, MD

Blood (2004) 104 (11): 3577.

https://doi.org/10.1182/blood.V104.11.3577.3577

Published: 2004

NARROW

The Pyruvate Kinase Activator Mitapivat Ameliorates Anemia and Prevents Iron Overload in a Mouse Model of Hereditary Spherocytosis

Measuring Reticulocyte Hemoglobin Content As a Marker for Iron Deficiency and Response to Therapy Represents a Paradigm Shift in Care

Dietary Omega-3 Fatty Acid Supplementation Improves Sickle Cell Bone Disease By Affecting Osteoblastogenesis and Adipogenesis

Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease

Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction

Imatinib Protects Against Hypoxia/Reoxygenation Induced Lung and Kidney Injury in a Humanized Mouse Model for SCD

Acoustic Levitation: A Novel Approach to Study the Physical Properties of Blood in Normal Subjects and in Patients with Sickle Cell Disease

A Selective ORAL GLYT1 Inhibitor, Improves Anemia and RED CELL Survival in a MOUSE MODEL of Beta-Thalassemia

Resolvin D1 and Resolvin D2 Protect Against Hypoxia/Reoxygenation Induced Lung and Kidney Damage in a Sickle Cell Mouse Model of Acute Vaso-Occlusive Crisis

Dietary ω-3 Fatty Acid Supplementation As a Potential New Therapy for Vasculopathy in Sickle Cell Disease: Proof of Concept in a Transgenic Mouse Model

Senicapoc, a Gardos Channel Inhibitor Developed to Treat Sickle Cell Disease, Exhibits Antimalarial Activity

Pharmacological Inhibition of Calpain-1 Prevents Red Cell Dehydration and Reduces Gardos Channel Activity in a Mouse Model of Sickle Cell Disease. Identification of Druggable Protease Target

Footprints of Response to Hydroxyurea Are in the Hemogram.

Effects of Hydroxyurea (HU) and Magnesium Pidolate (Mg) in Hemoglobin SC Disease (HbSC): the “CHAMPS” Trial.

Genetic Evidence That Sequence Variation at the β-Globin Locus Underlies Differences in Cell Hemoglobin Concentration and Cell Hydration in Single ( Hbb s ) Vs. Diffuse ( Hbb d ) Inbred Mouse Strains: Implications for Inherited Anemias

Regulators of Erythrocyte Volume as Modifiers in Sickle Cell Disease: The Gardos Channel.

Various Drugs with or without an Antisickling Effect in the In Vitro Tests Showed a Strong Antisickling Effect in the In Vivo Studies in Transgenic Sickle Mice.

The Safety and Efficacy of Oral Magnesium Pidolate in Children with Hemoglobin SC Disease.

MSDD1, a Prodrug of 5-Hydroxymethyl-2-Furfural (5HMF), Prolongs the Antisickling Effect of 5HMF in Transgenic Sickle Mice.

PDE-4 Inhibitor Rolipram Prevents Hypoxia Induced Pulmonary Hypertension in Transgenic Sickle Cell Sad Mice.

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American Society of Hematology

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American Society of Hematology

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