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Charles Y. Lin, PhD
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Journal Articles

Targeting MM at the Nexus between Cell Cycle and Transcriptional Regulation Via CDK7 Inhibition

Yao Yao, Woojun D Park, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Nicholas P Kwiatkowski, PhD, Yan Xu, MD, Chandraditya Chakraborty, PhD, Behnam Nabet, PhD, Marta Chesi, PhD, Herve Avet-Loiseau, Nathaniel Gray, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Nikhil C. Munshi, MD, Mariateresa Fulciniti, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-142592
Published: 2020
Journal Articles

RNA Regulator of Lipogenesis (RROL) Is a Novel Lncrna Mediating Protein-Protein Interaction at Gene Regulatory Loci Driving Lipogenic Programs in Multiple Myeloma

Eugenio Morelli, MD, Mariateresa Fulciniti, PhD, Mehmet K. Samur, PhD, Caroline Ribeiro, PhD, Leon Wert-Lamas, PhD, Annamaria Gulla, MD, Anil Aktas-Samur, PhD, Katia Todoerti, PhD, Srikanth Talluri, PhD, Woojun Daniel Park, Jonathan E Henninger, Cinzia Federico, PhD, Giada Bianchi, MD, Francesca Scionti, PhD, Yao Yao, Nicola Amodio, PhD, Charles Y Lin, PhD, Yu-Tzu Tai, PhD, Pierfrancesco Tassone, MD, Antonino Neri, MD, Dharminder Chauhan, PhD, Teru Hideshima, MD PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Carl D. Novina, MD PhD, Massimo Loda, MD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
https://doi.org/10.1182/blood-2020-142514
Published: 2020
Journal Articles

An Oncogenic Enhancer Encodes Selective Selenium Dependency in AML

Charles Y Lin, PhD, Joanna S. Yi, MD, Yajian Jiang, MBBS, Daisuke Nakada, PhD, Monika Perez, BS, Jost Koren, M.S., Kenneth Eagle
Journal: Blood
Blood (2019) 134 (Supplement_1): 638.
https://doi.org/10.1182/blood-2019-129433
Published: 2019
Journal Articles

Integrating Enhancer Profiling and CRISPR Dropout Screen Revealed Selenoprotein Synthesis Pathway As a New Vulnerability in AML

Yajian Jiang, MBBS, Xiangguo Shi, PhD, Kenneth Eagle, Charles Y Lin, PhD, Daisuke Nakada, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 639.
https://doi.org/10.1182/blood-2019-126904
Published: 2019
Journal Articles

Rara Is a Druggable Super-Enhancer Regulated Dependency in Pediatric AML

Alfred S. Daramola, MS, Monika Perez, BS, Oscar S. Sias-Garcia, MS, Maci S. Terrell, BS, Helen Y Wei, BS, Nikitha Cherayil, BS, Alexandra McLean Stevens, MD PhD, Charles Y Lin, PhD, Joanna S. Yi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 281.
https://doi.org/10.1182/blood-2019-125425
Published: 2019
Journal Articles

Core Transcriptional Regulatory Circuitries in AML

Maxim Pimkin, MD PhD, Juliana Xavier Ferrucio, PhD, Neekesh Vijay Dharia, MD PhD, Taku Harada, Andrew Kossenkov, Selma Elsarrag, Jazmin Ewers, Charles Y Lin, PhD, Kimberly Stegmaier, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 280.
https://doi.org/10.1182/blood-2019-129297
Published: 2019
Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2018-99-119941
Published: 2018
Journal Articles

Targeting Distinct Promoter- and Enhancer-Driven Dependencies in Multiple Myeloma

Chandraditya Chakraborty, PhD, Mehmet Kemal Samur, PhD, Richard A. Young, PhD, Kenneth Anderson, MD, Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3156.
https://doi.org/10.1182/blood-2018-99-112583
Published: 2018
Journal Articles

Mapping of the Multiple Myeloma Transcriptional Core Regulatory Circuitry Reveals TCF3 As a Novel Dependency and an Oncogenic Collaborator of MYC

Charles Y Lin, PhD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Mehmet Kemal Samur, PhD, Raphael Szalat, MD, Christopher J. Ott, PhD, Charles Epstein, Richard A. Young, PhD, James Bradner, MD, Kenneth C Anderson, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 64.
https://doi.org/10.1182/blood.V130.Suppl_1.64.64
Published: 2017
Journal Articles

Integrative Oncogenomic Analysis Combining Whole Genome, Transcriptome and Epigenome Identifies Altered Chromatin Accessibility Landscape in Multiple Myeloma

Raphael Szalat, MD, Mehmet Kemal Samur, PhD, Christopher J. Ott, PhD, Matthew Lawlor, Charles Epstein, Brian J Abraham, PhD, Charles Y Lin, PhD, Linying Zhang, Rao Prabhala, PhD, Nina Farrell, Kenneth Wes, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Giovanni Parmigiani, Richard A. Young, PhD, Kenneth C Anderson, MD, Nikhil Munshi, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 328.
https://doi.org/10.1182/blood.V130.Suppl_1.328.328
Published: 2017
Journal Articles

Disruption Of Super Enhancer-Driven Cancer Dependencies In Diffuse Large B-Cell Lymphoma

Bjoern Chapuy, MD, PhD, McKeown Michael, Charles Y. Lin, PhD, Stefano Monti, PhD, Margaretha GM Roemer, Jun Qi, Peter B. Rahl, PhD, Heather Sun, Kelly T. Yeda, Andrew L. Kung, MD, PhD, Scott J. Rodig, MD, PhD, Richard A. Young, PhD, Margaret A. Shipp, MD, James E. Bradner, MD
Journal: Blood
Blood (2013) 122 (21): 3021.
https://doi.org/10.1182/blood.V122.21.3021.3021
Published: 2013