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Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39.

https://doi.org/10.1182/blood-2020-140044

Published: 2020

Journal Articles

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Martin P. Carroll, MD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, MDPhD, Sung June Lee, BA, Anil Kumar, PhD, Anne Lehman, Joseph Patrick Loftus, BS, Grace Jeschke, PhD, John D. Crispino, PhD, Thierry Besson, PhD, Junwei Shi, PhD, Srividya Swaminathan, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-141258

Published: 2020

Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 3944.

https://doi.org/10.1182/blood-2019-130774

Published: 2019

Journal Articles

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Rahul S. Bhansali, Anne Lehman, Grace Jeschke, PhD, John D. Crispino, PhD MBA, Thierry Besson, PhD, Sarah K. Tasian, MD, Martin Carroll, MD

Blood (2019) 134 (Supplement_1): 2742.

https://doi.org/10.1182/blood-2019-123475

Published: 2019

Journal Articles

Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Joseph Patrick Loftus, BS, Daniel Blumenthal, PhD, Anne Lehman, Yong Li, Bryan Manning, Katherine D Cummins, BMBS, Janis K Burkhardt, PhD, Alexander E. Perl, MD, Martin Carroll, MD, Sarah K. Tasian, MD

Blood (2019) 134 (Supplement_1): 747.

https://doi.org/10.1182/blood-2019-123514

Published: 2019

Journal Articles

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Lai N Chan, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Erica Ballabio, Gang Xiao, PhD, Gauri Deb, MS, PhD, Haytham Khoury, MD PhD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Tom Arthur Milne, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 1239.

https://doi.org/10.1182/blood-2019-131565

Published: 2019

Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 568.

https://doi.org/10.1182/blood-2018-99-115536

Published: 2018

Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 1336.

https://doi.org/10.1182/blood-2018-99-115514

Published: 2018

Journal Articles

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Scott Armstrong, MD PhD, Thomas Arthur Milne, PhD BSc, MSc, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1210.

https://doi.org/10.1182/blood.V130.Suppl_1.1210.1210

Published: 2017

Journal Articles

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Rebecca Caesar, Seyedmehdi Shojaee, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Steven Kornblau, MD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1211.

https://doi.org/10.1182/blood.V130.Suppl_1.1211.1211

Published: 2017

Journal Articles

Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells

Christian Hurtz, PhD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Bruce Ruggeri, Matthew C. Stubbs, Alexander E. Perl, MD, Martin Carroll, MD

Blood (2017) 130 (Supplement 1): 717.

https://doi.org/10.1182/blood.V130.Suppl_1.717.717

Published: 2017

Journal Articles

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

Jae-Woong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MD PhD, Lars Klemm, BSc, MSc, Kadriye Nehir Cosgun, PhD, Gang Xiao, PhD, Behzad Masouleh, Christian Hurtz, PhD, Samir Parekh, MD, Steven M. Kornblau, MD, Ari Melnick, MD, Abul Abbas, Elisabeth Paietta, Markus Müschen, MD PhD

Blood (2016) 128 (22): 4088.

https://doi.org/10.1182/blood.V128.22.4088.4088

Published: 2016

Journal Articles

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Lai N Chan, PhD, Christian Hurtz, PhD, Gang Xiao, PhD, Seyedmehdi Shojaee, PhD, Rebecca Caeser, Huimin Geng, PhD, Ari Melnick, MD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 438.

https://doi.org/10.1182/blood.V128.22.438.438

Published: 2016

Journal Articles

Oncogenic Feedback Activation Between BCL6 and MLL Promotes Malignant Transformation in MLL -RearrangedAcute Lymphoblastic Leukemia

Christian Hurtz, PhD, Lai N Chan, PhD, Erica Ballabio, MD, Cheryl L. Willman, William L. Carroll, MD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Thomas Milne, PhD, Markus Müschen, MD PhD

Blood (2016) 128 (22): 907.

https://doi.org/10.1182/blood.V128.22.907.907

Published: 2016

Journal Articles

Adaptive Reactivation of Signaling Pathways As a Novel Mechanism of Resistance to JAK Inhibitors in Ph-like ALL

Christian Hurtz, PhD, Sarah K Tasian, MD, Gerald Wertheim, MD PhD, Rachel Astles, BA, Alexis Zebrowski, BA, Alexander E. Perl, MD, Martin Carroll, MD

Blood (2016) 128 (22): 755.

https://doi.org/10.1182/blood.V128.22.755.755

Published: 2016

Journal Articles

B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling

Blood (2015) 126 (23): 1255.

https://doi.org/10.1182/blood.V126.23.1255.1255

Published: 2015

Journal Articles

Identification of BCL6 As a Therapeutic Target in RAS -Driven Acute Lymphoblastic Leukemia

Qiang Li, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen, MDPhD

Blood (2015) 126 (23): 556.

https://doi.org/10.1182/blood.V126.23.556.556

Published: 2015

Journal Articles

Extrafollicular CD4 + T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation

Ruishu Deng, MD PhD, Christian Hurtz, PhD, Chanyu Yue, PhD, Gang Xiao, PhD, Hua Yu, PhD, Markus Muschen, MDPhD, Stephen J. Forman, MD, Paul J. Martin, MD, Defu Zeng, MD

Blood (2015) 126 (23): 1875.

https://doi.org/10.1182/blood.V126.23.1875.1875

Published: 2015

Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Blood (2014) 124 (21): 284.

https://doi.org/10.1182/blood.V124.21.284.284

Published: 2014

Journal Articles

BCL6 Enables RAS -Mediated Pre-B Cell Transformation in Childhood Acute Lymphoblastic Leukemia

Christian Hurtz, PhD, Huimin Geng, PhD, Gang Xiao, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen, MD PhD

Blood (2014) 124 (21): 3570.

https://doi.org/10.1182/blood.V124.21.3570.3570

Published: 2014

NARROW

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

DYRK1A Is Required to Alleviate Replication Stress in KMT2A -Rearranged Acute Lymphoblastic Leukemia

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A -Rearranged Acute Lymphoblastic Leukemia

Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Reciprocal Regulation of BCL6 and MLL Expression As a Vulnerability in MLL -Rearranged Acute Lymphoblastic Leukemia

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells

CD25 Enables Oncogenic BCR Signaling and Represents a Therapeutic Target in Refractory B Cell Malignancies

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Oncogenic Feedback Activation Between BCL6 and MLL Promotes Malignant Transformation in MLL -RearrangedAcute Lymphoblastic Leukemia

Adaptive Reactivation of Signaling Pathways As a Novel Mechanism of Resistance to JAK Inhibitors in Ph-like ALL

B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling

Identification of BCL6 As a Therapeutic Target in RAS -Driven Acute Lymphoblastic Leukemia

Extrafollicular CD4 + T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

BCL6 Enables RAS -Mediated Pre-B Cell Transformation in Childhood Acute Lymphoblastic Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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