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Craig E. Hughes
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Journal Articles

Inhibition of Btk Does Not Block Platelet Activation By GPVI: Studies with Ibrunitib, Acalabrutinib and Patients with X-Linked Agammaglobulinaemia

Phillip LR Nicolson, MA, MBBChir, MRCP, Stephanie Watson, BSc, Craig E Hughes, BSc, PhD, Alexander T Hardy, BSc, Callum N Watson, BSc, Samantha J Montague, BSc, PhD, Michael G Tomlinson, BSc, PhD, Guy Pratt, MD FRCP, FRCPath, Steve P Watson, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1030.
https://doi.org/10.1182/blood.V130.Suppl_1.1030.1030
Published: 2017
Journal Articles

Fibrin activates GPVI in human and mouse platelets

Osama M. Alshehri, Craig E. Hughes, Samantha Montague, Stephanie K. Watson, Jon Frampton, Markus Bender, Steve P. Watson
Journal: Blood
Blood (2015) 126 (13): 1601–1608.
https://doi.org/10.1182/blood-2015-04-641654
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

Craig E. Hughes, Brenda A. Finney, Frank Koentgen, Kate L. Lowe, Steve P. Watson
Journal: Blood
Blood (2015) 125 (1): 144–154.
https://doi.org/10.1182/blood-2014-05-579375
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice

Deya Cherpokova, Markus Bender, Martina Morowski, Peter Kraft, Michael K. Schuhmann, Sarah M. Akbar, Cheryl S. Sultan, Craig E. Hughes, Christoph Kleinschnitz, Guido Stoll, Leonard L. Dragone, Steve P. Watson, Michael G. Tomlinson, Bernhard Nieswandt
Journal: Blood
Blood (2015) 125 (1): 185–194.
https://doi.org/10.1182/blood-2014-06-580597
Published: 2015
Includes: Supplemental data
Journal Articles

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

Brenda A. Finney, Edina Schweighoffer, Leyre Navarro-Núñez, Cecile Bénézech, Francesca Barone, Craig E. Hughes, Stacey A. Langan, Kate L. Lowe, Alice Y. Pollitt, Diego Mourao-Sa, Steve Sheardown, Gerard B. Nash, Nicholas Smithers, Caetano Reis e Sousa, Victor L. J. Tybulewicz, Steve P. Watson
Journal: Blood
Blood (2012) 119 (7): 1747–1756.
https://doi.org/10.1182/blood-2011-09-380709
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

CLEC-2 activates Syk through dimerization

Craig E. Hughes, Alice Y. Pollitt, Jun Mori, Johannes A. Eble, Michael G. Tomlinson, John H. Hartwig, Christopher A. O'Callaghan, Klaus Fütterer, Steve P. Watson
Journal: Blood
Blood (2010) 115 (14): 2947–2955.
https://doi.org/10.1182/blood-2009-08-237834
Published: 2010
Includes: Supplemental data