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Journal Articles

Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples

Michael Slade, MDMS, Michelle O'Laughlin, Robert S Fulton, Eric J. Duncavage, MD, Timothy J Ley, MD, Meagan A. Jacoby, MD, David H Spencer, MD

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-133279

Published: 2020

Journal Articles

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Julia T Warren, MD PhD, Peeradol Wattanasirakul, David H Spencer, MD, Adam Locke, PhD, Vahagn Makaryan, MD, Audrey Anna Bolyard, RN, BS, Karl Welte, Julia Skokowa, MD PhD, David C. Dale, MD, Daniel C. Link, MD

Blood (2019) 134 (Supplement_1): 433.

https://doi.org/10.1182/blood-2019-129635

Published: 2019

Journal Articles

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Ellie Wilson, BS, Nichole Helton, Catrina Fronick, BS, Robert Fulton, MS, John S. Welch, MD PhD, Timothy J Ley, MD, David H Spencer, MD

Blood (2019) 134 (Supplement_1): 3755.

https://doi.org/10.1182/blood-2019-122340

Published: 2019

Journal Articles

Homozygous Loss of a Critical CTCF Recognition Sequence in the HOXA gene Cluster Eliminates CTCF Binding but Does Not Appreciably Reduce HOXA9 expression in NPM1 Mutated AML Cells

Reza Ghasemi, PhD, Struthers B Heidi, David H Spencer, MD PhD

Blood (2018) 132 (Supplement 1): 2613.

https://doi.org/10.1182/blood-2018-99-119000

Published: 2018

Journal Articles

Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance

Blood (2018) 132 (Supplement 1): 5277.

https://doi.org/10.1182/blood-2018-99-114979

Published: 2018

Journal Articles

Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations

David H Spencer, MD/PhD, Margaret A. Young, MD/PhD, Jeffery M. Klco, MD/PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 2496.

https://doi.org/10.1182/blood.V122.21.2496.2496

Published: 2013

Journal Articles

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

David A. Russler-Germain, B.S., David H Spencer, MD/PhD, Margaret A. Young, MD/PhD, Tamara Lamprecht, B.S., Chris Miller, PhD, Robert S. Fulton, Petra Gilmore, PhD, Reid Townsend, MD, PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 3812.

https://doi.org/10.1182/blood.V122.21.3812.3812

Published: 2013

Journal Articles

Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA

Christopher B Cole, Angela M. Verdoni, PhD, David H Spencer, MD/PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 477.

https://doi.org/10.1182/blood.V122.21.477.477

Published: 2013

Journal Articles

Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice

Jeffery M. Klco, MD/PhD, David H Spencer, MD/PhD, Christopher A Miller, PhD, Tamara Lamprecht, Dan George, Robert S. Fulton, Richard K Wilson, PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 609.

https://doi.org/10.1182/blood.V122.21.609.609

Published: 2013

Journal Articles

Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia

Maria Trissal, BS, David H Spencer, MD/PhD, Jessica Silva, PhD, Todd Wylie, BS, Jasreet Hundal, MS, Sean McGrath, MS, Vincent Magrini, PhD, Giridharan Ramsingh, Richard J Wilson, PhD, Timothy J. Ley, MD, Daniel C. Link

Blood (2012) 120 (21): 3500.

https://doi.org/10.1182/blood.V120.21.3500.3500

Published: 2012

Journal Articles

Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse

Jeffery M. Klco, MD/PhD, David H Spencer, MD/PhD, Chris Miller, PhD, Tamara Lamprecht, Robert S. Fulton, John S. Welch, MD/PhD, Li Ding, Richard K Wilson, Timothy J. Ley, MD

Blood (2012) 120 (21): 407.

https://doi.org/10.1182/blood.V120.21.407.407

Published: 2012

Journal Articles

In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples.

David H Spencer, MD/PhD, Jeffery M. Klco, MD/PhD, Tamara Lamprecht, Todd Wylie, BS, Vincent Magrini, PhD, Jasreet Hundal, MS, Jason Walker, BA, BS, Nobish Varghese, MS, Matthew R Meyer, PhD, Petra Gilmore, PhD, Reid Townsend, MD, PhD, Elaine R. Mardis, PhD, Timothy J. Ley, MD

Blood (2012) 120 (21): 2527.

https://doi.org/10.1182/blood.V120.21.2527.2527

Published: 2012

Journal Articles

Detection of FLT3 Internal Tandem Duplications in Acute Myeloid Leukemia by Targeted Multi-Gene Next Generation Sequencing,

David H Spencer, MD/PhD, Haley Abel, Ph.D., Philippe Szankasi, PhD, Todd W. Kelley, MD, Shashikant Kulkarni, PhD, Mark A. Watson, MD, PhD, John D Pfeifer, MD, PhD, Eric J. Duncavage, MD

Blood (2011) 118 (21): 3547.

https://doi.org/10.1182/blood.V118.21.3547.3547

Published: 2011

NARROW

Comparison of Deep Whole Exome Versus Targeted Gene Sequencing for Assessment of Persistent Molecular Disease in Acute Myeloid Leukemia Samples

Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia

Whole Genome Bisulfite Sequencing of 63 Primary AML Samples Identifies a Unique DNA Hypermethylation Signature for Mutant IDH1/2 Cases That Is Different from That of TET2 Mutant AML

Homozygous Loss of a Critical CTCF Recognition Sequence in the HOXA gene Cluster Eliminates CTCF Binding but Does Not Appreciably Reduce HOXA9 expression in NPM1 Mutated AML Cells

Improving Risk Assessment of AML with a Precision Genomic Strategy to Assess Mutation Clearance

Comprehensive Analysis Of HOX Gene Expression and DNA Methylation From 189 Primary AMLs Demonstrates Canonical Patterns Associated With Hematopoietic Stem/Progenitors and Recurrent AML Mutations

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

Dnmt3a is Required For Aberrant Self-Renewal Driven by PML-RARA

Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice

Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia

Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse

In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples.

Detection of FLT3 Internal Tandem Duplications in Acute Myeloid Leukemia by Targeted Multi-Gene Next Generation Sequencing,

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American Society of Hematology

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ASH Publications

American Society of Hematology

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