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David R Myers, PhD
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Journal Articles

Stiff Erythrocyte Subpopulations Biomechanically Induce Endothelial Inflammation in Sickle Cell Disease

Christina Caruso, MD, Xiao Zhang, BS, Yumiko Sakurai, MSc, Wei Li, MD, Meredith E. Fay, BS, Marcus A. Carden, MD, David R. Myers, PhD, Robert G. Mannino, PhD, Clinton H. Joiner, MD PhD, Michael D. Graham, PhD, Wilbur A. Lam, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3560.
https://doi.org/10.1182/blood-2019-125408
Published: 2019
Journal Articles

Increased Platelet Force Is Associated with Decreased Bleeding Severity in Pediatric Immune Thrombocytopenia

Oluwamayokun T. Oshinowo, BS, Renee Copeland, BS, Christina Caruso, MD, Meredith E. Fay, BS, Traci Leong, PhD, Carolyn M. Bennett, MDMSc, Wilbur A. Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1096.
https://doi.org/10.1182/blood-2019-129573
Published: 2019
Journal Articles

Platelet Contraction Force As a Biophysical Biomarker for Bleeding Risk in Patients with Immune Thrombocytopenia

Oluwamayokun T. Oshinowo, Renee Copeland, BS, Carolyn M. Bennett, MD MSc, Wilbur A Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 517.
https://doi.org/10.1182/blood-2018-99-115292
Published: 2018
Journal Articles

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Renee Copeland, BS, Oluwamayokun T. Oshinowo, Yumiko Sakurai, MSc, Meredith Ellen Fay, BS, Brian G. Petrich, PhD, Benjamin Brainard, VMD, Dipl ACVAA, ACVECC, Wilbur A Lam, MD PhD, David R. Myers, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 869.
https://doi.org/10.1182/blood-2018-99-113107
Published: 2018
Journal Articles

Platelet Contraction Cytometry: A Biophysical, High-Throughput Research-Enabling and Diagnostic Platform

Oluwamayokun T. Oshinowo, Aaron W. Lam, Benjamin Brainard, VMD, Dipl ACVAA, ACVECC, Carolyn M. Bennett, MD MSc, Wilbur A. Lam, MDPhD, David R. Myers, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2301.
https://doi.org/10.1182/blood.V130.Suppl_1.2301.2301
Published: 2017
Journal Articles

Clot Formation Under Physiological Flow Conditions Is Altered in Sickle Cell Disease As Measured By a Multiparameter Microfluidic System

Abhijit Ravindran, John Baek, BS, David R. Myers, PhD, Wilbur A. Lam, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 539.
https://doi.org/10.1182/blood.V130.Suppl_1.539.539
Published: 2017
Journal Articles

Leveraging the Contractile Force of Platelets for Targeted Factor VIII Delivery in Hemophilia with Inhibitors

Caroline E. Hansen, BS, David R Myers, PhD, Yumiko Sakurai, MSc, Wallace Hunter Baldwin, BS, Shannon L. Meeks, MD, L. Andrew Lyon, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2016) 128 (22): 81.
https://doi.org/10.1182/blood.V128.22.81.81
Published: 2016
Journal Articles

Improving Lentiviral Transduction Efficiency with Microfluidic Systems

Reginald Tran, BS, David R Myers, PhD, Jordan E Shields, MS, Byungwook Ahn, PhD, Yongzhi Qiu, PhD, Caroline Hansen, BS, Yumiko Sakurai, MSc, Robert Moot, BS, H. Trent Spencer, PhD, Christopher B Doering, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4415.
https://doi.org/10.1182/blood.V126.23.4415.4415
Published: 2015
Journal Articles

Vessel Geometry Interacts with Red Blood Cell Stiffness to Promote Endothelial Dysfunction in Sickle Cell Disease

Yichen Wang, Robert G Mannino, BS, David R Myers, PhD, Wei Li, Clinton H. Joiner, MD PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 965.
https://doi.org/10.1182/blood.V126.23.965.965
Published: 2015
Journal Articles

Clot Contraction-Mediated Erythrocyte Packing Is Significantly Altered in Sickle Cell Disease

Hunter Strauss, David R Myers, PhD, Margo Renee Rollins, MD, John W. Weisel, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2015) 126 (23): 215.
https://doi.org/10.1182/blood.V126.23.215.215
Published: 2015
Journal Articles

Vascular Geometry and Flow Profile Mediate Pathological Cell-Cell Interactions in Sickle Cell Disease As Measured with "Do-It-Yourself" "Endothelial-Ized" Microfluidics

Robert Mannino, BS, David R Myers, PhD, Byungwook Ahn, PhD, Hope Gole, PhD, Yichen Wang, Angela Lin, Robert Guldberg, PhD, Don Giddens, PhD, Lucas Timmins, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 454.
https://doi.org/10.1182/blood.V124.21.454.454
Published: 2014
Journal Articles

“Self-Deposition” of Matrix Proteins from Platelet α-Granules Enable Extended Adhesion and Spreading on Micron/Submicron-Scale Fibrinogen and Collagen Substrates.

Yumiko Sakurai, MSc, Jennifer L Fitch-Tewfik, PhD, Yongzhi Qiu, PhD, David R Myers, PhD, Byungwook Ahn, PhD, Robert Flaumenhaft, MD/ PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2764.
https://doi.org/10.1182/blood.V124.21.2764.2764
Published: 2014
Journal Articles

Platelet Mechanosensing of Collagen Matrices

Matthew F Kee, Yongzhi Qiu, PhD, David R Myers, PhD, Yumiko Sakurai, MSc, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1437.
https://doi.org/10.1182/blood.V124.21.1437.1437
Published: 2014
Journal Articles

Platelet Adhesion, Spreading and Activation Are Mediated By Mechanosensing of Matrix Stiffness

Yongzhi Qiu, PhD, Ashley C Brown, PhD, David R Myers, PhD, Yumiko Sakurai, MSc, Robert Mannino, BS, Reginald Tran, BS, Byungwook Ahn, PhD, Elaissa Hardy, PhD, Matthew F Kee, Sanjay Kumar, MD, PhD, Gang Bao, PhD, Thomas H Barker, PhD, Wilbur A Lam, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1438.
https://doi.org/10.1182/blood.V124.21.1438.1438
Published: 2014
Journal Articles

White Blood Cell Mechanics Mediate Glucocorticoid- and Catecholamine-Induced Demargination

Meredith E Fay, David R Myers, PhD, Amit Kumar, PhD, Rebecca Byler, Todd A Sulchek, PhD, Michael D Graham, PhD, Wilbur A Lam, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3459.
https://doi.org/10.1182/blood.V122.21.3459.3459
Published: 2013
Journal Articles

New Insights Into The Mechanisms Of Ferric Chloride-Induced Thrombosis: a Reductionist Microfluidic Approach

Jordan C Ciciliano, BS, David R Myers, PhD, Meredith E Fay, Yumiko Sakurai, MSc, Renhao Li, PhD, Andrew Lyon, PhD, Wilbur A Lam, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2308.
https://doi.org/10.1182/blood.V122.21.2308.2308
Published: 2013
Journal Articles

Spatial Regulation of Platelet Aggregation and Physiology Under Flow

Reginald Tran, BS, Byungwook AHN, PhD, David R Myers, PhD, Yongzhi Qiu, PhD, Yumiko Sakurai, MSc
Journal: Blood
Blood (2012) 120 (21): 3300.
https://doi.org/10.1182/blood.V120.21.3300.3300
Published: 2012
Journal Articles

An “Endothelialized” Microfluidic System That Distinguishes Procoagulant Mechanisms in Arterial and Venous Thrombosis

Byungwook Ahn, PhD, Yumiko Sakurai, MSc, David R Myers, PhD, Yongzhi Qiu, PhD, Elaissa Hardy, PhD, Reginald Tran, BS, Robert Mannino, Alisa S. Wolberg, PhD, Wilbur Lam, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1071.
https://doi.org/10.1182/blood.V120.21.1071.1071
Published: 2012
Journal Articles

High-Throughput Nanomechanical Platelet Contraction Measurements Using Patterned Hydrogels.

David R Myers, PhD, Ashley C Brown, PhD, Yongzhi Qiu, PhD, Yumiko Sakurai, MSc, Reginald Tran, BS, Byungwook Ahn, PhD, Robert Mannino, Todd Sulchek, PhD, Andew Lyon, PhD, Thomas H Barker, PhD, Wilbur Lam, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2172.
https://doi.org/10.1182/blood.V120.21.2172.2172
Published: 2012
Journal Articles

Platelet Mechanosensing: Adhesion and Spreading On Immobilized Fibrinogen Depends On Substrate Stiffness

Yongzhi Qiu, PhD, Ashley C Brown, PhD, Woo Jin Jung, Yumiko Sakurai, MSc, Robert Mannino, David R Myers, PhD, Reginald Tran, BS, Gang Bao, PhD, Thomas H Barker, PhD, Wilbur Lam, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 384.
https://doi.org/10.1182/blood.V120.21.384.384
Published: 2012