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Journal Articles

Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant

Karin Gustafsson, PhD, Catherine S Rhee, PhD, Elizabeth W Scadden, Vanessa Frodermann, Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Anthony E Boitano, PhD, Michael P. Cooke, PhD, Matthias Nahrendorf, PhD, David T. Scadden, MD

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-143176

Published: 2020

Journal Articles

Mgta-145, in Combination with Plerixafor in a Phase 1 Clinical Trial, Mobilizes Large Numbers of Human Hematopoietic Stem Cells and a Graft with Immunosuppressive Effects for Allogeneic Transplant

Kevin A. Goncalves, PhD, Sharon L. Hyzy, MS, Katelyn J. Hammond, BS, Patrick C. Falahee, PhD, Haley Howell, BS, BA, Jan Pinkas, PhD, Veit Schmelmer, PhD, Jonathan G. Hoggatt, PhD, David T. Scadden, MD, Steven M Devine, MD, John F. DiPersio, MD PhD, Will J. Savage, MDPhD, John C. Davis, Jr., MD MPH, MS

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-142804

Published: 2020

Journal Articles

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Catherine S Rhee, PhD, Elizabeth W Scadden, Chea L Phillip, Bum-Kyu Lee, PhD, Meeta Mistry, Friedrich F Hoyer, MD, Hiroki Kato, MD PhD, Giovanna Mantica, Jonghwan Kim, PhD, Matthias Nahrendorf, PhD, Michael K Mansour, MD PhD, David B Sykes, MD PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 438.

https://doi.org/10.1182/blood-2019-124054

Published: 2019

Journal Articles

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

Karin Gustafsson, PhD, Nikolas Barkas, PhD, Ninib Baryawno, PhD, Elizabeth W Scadden, Nicolas Severe, PhD, Joel A Spencer, PhD, Hayalneh Gessessew, Kameron Kooshesh, Jimin Guo, PhD, Charles Lin, PhD, Peter Kharchenko, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 586.

https://doi.org/10.1182/blood-2019-126708

Published: 2019

Journal Articles

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Youmna Kfoury, PhD, Fei Ji, Michael Mazzola, BS, David B Sykes, MD PhD, Anselmo Anthony, Yasutoshi Akiyama, Allison Scherer, PhD, Francois Mercier, MD FRCPC, Nicolas Severe, PhD, Borja Saez, Jefferson Seidl, BA, Ani Papazian, BS, Thomas Brouse, Michael K Mansour, MD PhD, Pavel Ivanov, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 1207.

https://doi.org/10.1182/blood-2019-124794

Published: 2019

Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD

Blood (2019) 134 (Supplement_1): 3765.

https://doi.org/10.1182/blood-2019-123604

Published: 2019

Journal Articles

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

Nick van Gastel, PhD, Jessica B. Spinelli, PhD, Azeem Sharda, MS, Amir Schajnovitz, PhD, Ninib Baryawno, PhD, Catherine S Rhee, PhD, Toshihiko Oki, MD PhD, Eliane Grace, Heather J. Soled, Charles Vidoudez, PhD, Sunia A. Trauger, PhD, Marcia C. Haigis, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 3725.

https://doi.org/10.1182/blood-2019-124789

Published: 2019

Journal Articles

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Thomas J Fountaine, MD, Mark W LaMere, BA, Daniel K Byun, BS, Jason R Myers, MS, John M Ashton, PhD, Jane L. Liesveld, MD, Youmna Kfoury, PhD, David T. Scadden, MD, Michael W. Becker, MD, Laura M. Calvi, MD

Blood (2019) 134 (Supplement_1): 1708.

https://doi.org/10.1182/blood-2019-130227

Published: 2019

Journal Articles

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Youmna Kfoury, PhD, Esha Jain, Jason R Myers, MS, Fei Ji, David B Sykes, MD PhD, Francois Mercier, MD FRCPC, Ani Papazian, BS, Cam Le, Mark A Randolph, M.A.Sc., David P. Steensma, MD, Omar I Abdel-Wahab, MD, Laura M. Calvi, MD, Ruslan I Sadreyev, PhD, Michael W. Becker, MD, David T. Scadden, MD

Blood (2018) 132 (Supplement 1): 938.

https://doi.org/10.1182/blood-2018-99-115242

Published: 2018

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Blood (2018) 132 (Supplement 1): 55.

https://doi.org/10.1182/blood-2018-99-113916

Published: 2018

Journal Articles

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

Youmna Kfoury, PhD, Anthony Anselmo, PhD, Jefferson Seidl, BA, Ani Papazian, BS, Francois Mercier, MD FRCPC, David B Sykes, MD PhD, Nicolas Severe, PhD, Borja Saez, PhD, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 93.

https://doi.org/10.1182/blood.V130.Suppl_1.93.93

Published: 2017

Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2493.

https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493

Published: 2017

Journal Articles

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Nick van Gastel, PhD, Amir Schajnovitz, PhD, Charles Vidoudez, PhD, Toshihiko Oki, MD PhD, Azeem Sharda, MS, Sunia A. Trauger, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2523.

https://doi.org/10.1182/blood.V130.Suppl_1.2523.2523

Published: 2017

Journal Articles

Angiogenin Is a Niche-Secreted RNase Which Regulates Hematopoietic Regeneration

Lev Silberstein, MD PhD, Kevin Goncalves, PhD, Nicholas Severe, PhD, Guo-fu Hu, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 171.

https://doi.org/10.1182/blood.V128.22.171.171

Published: 2016

Journal Articles

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

Jonathan Hoggatt, PhD, Pratibha Singh, PhD, Tiffany Tate, BS, Peter V. Kharchenko, PhD, Amir Schajnovitz, PhD, Ninib Barawnyo, PhD, Francois Mercier, MD, Dwight Morrow, PhD, David T. Scadden, MD, Louis M. Pelus, PhD

Blood (2016) 128 (22): 368.

https://doi.org/10.1182/blood.V128.22.368.368

Published: 2016

Journal Articles

Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis

Nicolas Severe, PhD, Murat Karabacak, PhD, Ninib Baryawno, PhD, Karin Gustafsson, PhD, Youmna Sami Kfoury, PhD, Mehmet Toner, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 430.

https://doi.org/10.1182/blood.V128.22.430.430

Published: 2016

Journal Articles

Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins

Agnieszka Czechowicz, MD PhD, Rahul Palchaudhuri, PhD, Amelia Scheck, BS, Jonathan Hoggatt, PhD, Borja Saez, PhD, David T. Scadden, MD, Derrick J. Rossi, PhD

Blood (2016) 128 (22): 493.

https://doi.org/10.1182/blood.V128.22.493.493

Published: 2016

Journal Articles

In Vivo Analysis of Clonal Evolution of Multiple Myeloma

Yuji Mishima, PhD, Jiantao Shi, PhD, Michele Moschetta, MD, Yujia Shen, PhD, Salomon Manier, MD, Aldo M. Roccaro, MD PhD, Francois Mercier, MD FRCPC, Satoshi Takagi, PhD, Yawara Kawano, MD PhD, Shokichi Tsukamoto, MD PhD, Ilyas Sahin, Antonio Sacco, BS, Kiyohiko Hatake, MD PhD, Franziska Michor, PhD, David T. Scadden, MD, Irene M. Ghobrial, MD

Blood (2016) 128 (22): 799.

https://doi.org/10.1182/blood.V128.22.799.799

Published: 2016

Journal Articles

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, MD PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD, Mathias Wawer, PhD, Amir Schajnovitz, PhD, Hanna Meyer, PhD, Kerry A Pierce, PhD, Detlef Stoeckigt, PhD, Clary B Clish, PhD, Paul A Clemons, PhD, Andreas Janzer, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 1656.

https://doi.org/10.1182/blood.V128.22.1656.1656

Published: 2016

NARROW

Reversing Clonal Hematopoiesis and Associated Atherosclerotic Disease By Targeted Antibody-Drug-Conjugate (ADC) Conditioning and Transplant

Mgta-145, in Combination with Plerixafor in a Phase 1 Clinical Trial, Mobilizes Large Numbers of Human Hematopoietic Stem Cells and a Graft with Immunosuppressive Effects for Allogeneic Transplant

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Thymus Regeneration Is Dependent on Distinct Mesenchymal Stromal Cell Populations

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance

A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Untargeted Metabolomics Identifies Glutamine Metabolism As a Driver of Chemoresistance in Acute Myeloid Leukemia

Angiogenin Is a Niche-Secreted RNase Which Regulates Hematopoietic Regeneration

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis

Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins

In Vivo Analysis of Clonal Evolution of Multiple Myeloma

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

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American Society of Hematology

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American Society of Hematology

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