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Dennis Huszar, PhD
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Journal Articles

Targeting Hypersumoylation in Mantle Cell Lymphoma

Walter Hanel, MD PhD, Liudmyla Tsyba, PhD, Dennis Huszar, PhD, Alex Prouty, Xiaoli Zhang, PhD, JoBeth Helmig-Mason, Msc, Bethany L Mundy-Bosse, PhD, Youssef Youssef, MD, Samir Parekh, MD, Kami J. Maddocks, MD, Robert A Baiocchi, MD PhD, Lapo Alinari, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4060.
https://doi.org/10.1182/blood-2019-127363
Published: 2019
Journal Articles

Pharmacologic Inhibition of SUMO-Activating Enzyme (SAE) with TAK-981 Augments Interferon Signaling and Regulates T Cell Differentiation in Ex Vivo studies of Chronic Lymphocytic Leukemia (CLL)

Vi Lam, Scott R Best, BS, Nur Bruss, BS, Tingting Liu, Taylor Hashiguchi Rowland, BS, Dennis Huszar, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1760.
https://doi.org/10.1182/blood-2019-127539
Published: 2019
Journal Articles

Concurrent Inhibition of Pim-1 and FLT3 Kinases in FLT3-ITD Acute Myeloid Leukemia Post-Translationally Downregulates the Anti-Apoptotic Protein Mcl-1 through Downregulation of the Mcl-1 Deubiquitinase USP9X

Patrick R. Baldwin, PhD, Shivani Kapoor, B.S., Karthika Natarajan, PhD, Rossana Trotta, PhD, Adriana Tron, PhD, Dennis Huszar, PhD, Eduardo Davila, PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD
Journal: Blood
Blood (2016) 128 (22): 35.
https://doi.org/10.1182/blood.V128.22.35.35
Published: 2016
Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Kshama A. Doshi, M.S., Karthika Natarajan, PhD, Feyruz V. Rassool, PhD, Dennis Huszar, PhD, Maria R. Baer, MD
Journal: Blood
Blood (2015) 126 (23): 1268.
https://doi.org/10.1182/blood.V126.23.1268.1268
Published: 2015
Journal Articles

The Biologic Relevance of PIM Kinases in the Context of Multiple Myeloma and Their Potential As Therapeutic Targets in Combination Drug Therapy

Janani Ramachandran, MA, Loredana Santo, MD, Homare Eda, MDPhD, Dharminder Chauhan, PhD, Ka Tat Siu, PhD, Miroslav Koulnis, PhD, Dennis Huszar, PhD, Kenneth C Anderson, MD, Noopur S. Raje, MD
Journal: Blood
Blood (2015) 126 (23): 2992.
https://doi.org/10.1182/blood.V126.23.2992.2992
Published: 2015
Journal Articles

Synergistic Induction of Cell Death By Combined Inhibition of PIM and AKT Kinases in Cytogenetically Defined Standard and High-Risk Multiple Myeloma

Koremu Meja, Dean Smith, MBBS, Laura Percy, Dennis Huszar, PhD, Barry R Davies, Kwee L Yong, MBChB, PhD, Asim Khwaja
Journal: Blood
Blood (2014) 124 (21): 4723.
https://doi.org/10.1182/blood.V124.21.4723.4723
Published: 2014
Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Apoptosis Induction By Clinically Active FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and in Vivo through Synergistic Downregulation of Mcl-1 and of Bcl-xL

Karthika Natarajan, PhD, Trevor J Mathias, MS, Kshama A Doshi, MS, Adriana E Tron, PhD, Manfred Kraus, PhD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD, Dennis Huszar, PhD, Maria R Baer, MD
Journal: Blood
Blood (2014) 124 (21): 3601.
https://doi.org/10.1182/blood.V124.21.3601.3601
Published: 2014
Journal Articles

Effect of the Pan-PIM Kinase Inhibitor, AZD1208, Alone and in Combination with Bortezomib in Multiple Myeloma

Loredana Santo, Janani Ramachandran, Diana D Cirstea, Homare Eda, Neeharika Nemani, Teru Hideshima, Chauhan Dharminder, Dennis Huszar, PhD, Kenneth C. Anderson, MD, Noopur Raje, MD
Journal: Blood
Blood (2014) 124 (21): 5726.
https://doi.org/10.1182/blood.V124.21.5726.5726
Published: 2014
Journal Articles

Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation

Kristen A McEachern, PhD, Adriana E Tron, PhD, Greg O'Connor, Rachel DuPont, Francis D Gibbons, PhD, Lourdes Pablo, Karthick Vishwanathan, PhD, Patricia McCoon, PhD, Jorge E. Cortes, MD, Daniel J. DeAngelo, MDPhD, Mark D Minden, MDPhD, Geoffrey L. Uy, MD, Frank Neumann, MDPhD, Karen Keating, Dennis Huszar, PhD, J. Elizabeth Pease, PhD, Jeffrey Brown, PhD, J. Carl Barrett, PhD
Journal: Blood
Blood (2014) 124 (21): 906.
https://doi.org/10.1182/blood.V124.21.906.906
Published: 2014
Journal Articles

Effects of a Novel, Selective Jak2 Inhibitor, AZ60, on STAT5 Signaling and Cellular Growth in Jak2 V617F Cell Lines.

Joseph M. Gozgit, PhD, Geraldine A. Bebernitz, BS, Pankaj Patil, MS, Minwei Ye, MS, Jiaquan Wu, PhD, Stephanos Ioannidis, PhD, Audrey Davies, BS, Tao Wang, PhD, Dennis Huszar, PhD, Michael Zinda, PhD
Journal: Blood
Blood (2007) 110 (11): 3549.
https://doi.org/10.1182/blood.V110.11.3549.3549
Published: 2007
Journal Articles

A Selective and Potent Oral Inhibitor of the JAK2 Tyrosine Kinase Reverses Polycythemia and Leukocytosis Induced by JAK2 V617F in a Mouse Model.

Virginia M. Zaleskas, MD, Wayne W. Chan, BS, Peter Evangelista, BS, Katherine Lazarides, BS, Rajesh Chopra, MD, Michael Zinda, PhD, Dennis Huszar, PhD, Richard A. Van Etten, MD PhD
Journal: Blood
Blood (2007) 110 (11): 557.
https://doi.org/10.1182/blood.V110.11.557.557
Published: 2007