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Journal Articles

Targeting Sumoylation with Subasumstat (TAK-981), a Selective Inhibitor of SUMO-Activating Enzyme (SAE), Induces Mitochondrial Dysfunction in Preclinical Models of Non-Hodgkin Lymphoma (NHL)

Tingting Liu, Vi Lam, Elana Thieme, Olga Danilova, Nur Bruss, Lapo Alinari, Jeffrey W. Tyner, Stephen E. Kurtz, Zheng Xia, Alexey V Danilov
Journal: Blood
Blood (2022) 140 (Supplement 1): 6016–6017.
https://doi.org/10.1182/blood-2022-159691
Published: 2022
Journal Articles

Nedd8-Activating Enzyme Inhibition Enhances Anti-Tumor Immunity and PD1 Blockade in In Vivo lymphoma Models

Xiaoguang Wang, Vi Lam, Dan Vuong, Tingting Liu, Olga Danilova, Tanya Siddiqi, Allison J Berger, Lili Wang, Alexey V. Danilov
Journal: Blood
Blood (2021) 138 (Supplement 1): 2414.
https://doi.org/10.1182/blood-2021-146349
Published: 2021
Journal Articles

Final Results of a Phase 1/2 Study of SYK Inhibitor Entospletinib in Combination with Obinutuzumab in Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)

Alexey V. Danilov, Vi Lam, Bria Thurlow, Stephen E. Spurgeon, Byung Park, Kirsten Orand, Adam S Kittai
Journal: Blood
Blood (2021) 138 (Supplement 1): 2643.
https://doi.org/10.1182/blood-2021-146348
Published: 2021
Journal Articles

Pharmacologic Inhibition of SUMO-Activating Enzyme Potentiates Interferon Response and T Cell-Mediated Anti-Tumor Immunity in Chronic Lymphocytic Leukemia (CLL) and Lymphoma Models

Vi Lam, Xiaoguang Wang, Scott R Best, Nur Bruss, Tingting Liu, Olga Danilova, Tanya Siddiqi, Nathan Pennock, Alexey V. Danilov
Journal: Blood
Blood (2021) 138 (Supplement 1): 3719.
https://doi.org/10.1182/blood-2021-146347
Published: 2021
Journal Articles

Pharmacologic Inhibition of B Cell-Receptor-Associated Kinases with CG-806 Induces Apoptosis and Metabolic Reprogramming in Aggressive Non-Hodgkin Lymphoma (NHL) Models

Elana Thieme, Vi Lam, Nur Bruss, BS, Fei Xu, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Alexey Danilov, MD, Tingting Liu
Journal: Blood
Blood (2020) 136 (Supplement 1): 29.
https://doi.org/10.1182/blood-2020-134957
Published: 2020
Journal Articles

Pharmacologic Targeting MCL1 with AZD5991 Induces Apoptosis and Mitochondrial Dysfunction in Non-Hodgkin Lymphoma (NHL) Cells

Tingting Liu, Fei Xu, Elana Thieme, Vi Lam, Guang Fan, MD PhD, Liana Nikolaenko, MD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Olga Danilova, Alexey Danilov, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
https://doi.org/10.1182/blood-2020-134951
Published: 2020
Journal Articles

Neddylation Pathway Regulates Treg Differentiation and T Cell Function in Chronic Lymphocytic Leukemia (CLL) Ex Vivo and Murine In Vivo Studies

Scott R Best, BS, Vi Lam, Nur Bruss, BS, Taylor Hashiguchi Rowland, BS, Adam S. Kittai, MD, Tingting Liu, Allison J Berger, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4313.
https://doi.org/10.1182/blood-2019-123600
Published: 2019
Journal Articles

Pharmacologic Inhibition of SUMO-Activating Enzyme (SAE) with TAK-981 Augments Interferon Signaling and Regulates T Cell Differentiation in Ex Vivo studies of Chronic Lymphocytic Leukemia (CLL)

Vi Lam, Scott R Best, BS, Nur Bruss, BS, Tingting Liu, Taylor Hashiguchi Rowland, BS, Dennis Huszar, PhD, Alexey Danilov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1760.
https://doi.org/10.1182/blood-2019-127539
Published: 2019