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Journal Articles

New Molecular Evidence That Oct-4 Is Truly Expressed In a Rare Population Of Developmental Early Stem Cells In Human Umbilical Cord Blood (UCB) and That Epigenetic Modification Of Imprinting At Igf2-H19 Locus Regulates Their Quiescent State – Potential Implications For Regenerative Medicine

J Heo, MS, Dong Myung Shin, PhD, Kasia Mierzejewska, PhD, Malwina Suszynska, MS, Janina Ratajczak, MD, PhD, Magdalena Kucia, Ph.D., Mariusz Z Ratajczak, MD, PhD

Blood (2013) 122 (21): 2393.

https://doi.org/10.1182/blood.V122.21.2393.2393

Published: 2013

Journal Articles

Challenging Dogmas - Or How Much Evidence Is Necessary To Claim That There Is a Direct Developmental and Functional Link Between The Primordial Germ Cell (PGC) Lineage and Hematopoiesis?

Magdalena Kucia, Ph.D., Magda Maj, PhD, Kasia Mierzejewska, PhD, Dong-Myung Shin, PhD, Janina Ratajczak, MD, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2013) 122 (21): 1215.

https://doi.org/10.1182/blood.V122.21.1215.1215

Published: 2013

Journal Articles

Most Primitive Murine Bone Marrow Hematopoietic Stem Cells Express Several Primordial Germline Cells (PGCs) Markers, Including SALL4 - a Proposed Developmental Link Between Hematopoietic and Primordial Germ Cell Lineages

Magdalena Kucia, Ph.D., Kasia Mierzejewska, MS, Dong-Myung Shin, PhD, Yupo Ma, MD, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2012) 120 (21): 4745.

https://doi.org/10.1182/blood.V120.21.4745.4745

Published: 2012

Journal Articles

Single Cell Level Genome-Wide Gene Expression Analysis of Bone Marrow-Derived Oct-4 + very Small Embryonic-Like Stem Cells (VSELs) Revealed That a Polycomb Group Protein Ezh2 Regulates VSELs Pluripotency by Maintaining Bivalent Domains At Promoters of Important Homeodomain-Containing Developmental Transcription Factors

Magda Kucia, Ph.D., Rui Liu, Ph.D., Kasia Mierzejewska, MS, Wan Wu, Ph.D., Janina Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Mariusz Z Ratajczak

Blood (2011) 118 (21): 2345.

https://doi.org/10.1182/blood.V118.21.2345.2345

Published: 2011

Journal Articles

A Novel Perspective on Stem Cells, Tissue Senescence and Aging: Pluripotent Very Small Embryonic-Like Stem Cells (VSELs) and Hematopoietic Stem Cells (HSCs) Are Prematurely Depleted in Adult Bone Marrow (BM) in Response to Prolonged Growth Hormone/Insulin-Like Growth Factor-1 Signaling (IIS) and Chronic Increase in Caloric Uptake

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Rui Liu, Ph.D., Michal Masternak, Ph.D., Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D.

Blood (2011) 118 (21): 4818.

https://doi.org/10.1182/blood.V118.21.4818.4818

Published: 2011

Journal Articles

Novel View on Stem Cell Compartment and Aging - a Number of Pluripotent Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells in Murine Bone Marrow Is High in Several Long-Living and Reduced in Short-Living Murine Strains and Unexpectedly Inversely Correlates in These Animals with Plasma Growth Hormone/Insulin-Like Growth Factor-1 Level

Magda Kucia, Ph.D., Janina Ratajczak, MD, PhD, Rui Liu, MB, BS, Dong-Myung Shin, PhD, Michal Masternak, PhD, Andrzej Bartke, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2011) 118 (21): LBA-5–LAB-5.

https://doi.org/10.1182/blood.V118.21.LBA-5.LBA-5

Published: 2011

Journal Articles

The Number of Very Small Embryonic Like Stem Cells (VSELs) Decreases During Aging In An IGF-1-Dependent Manner - a Novel Link Between Aging, Caloric Restriction, and the Size of the Stem Cell Pool

Dong-Myung Shin, Ph.D., Wu Wan, BS, Rui Liu, MB, BS, Janina Ratajczak, MD, PhD, Andrzej Bartke, Ph.D., Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2010) 116 (21): 4796.

https://doi.org/10.1182/blood.V116.21.4796.4796

Published: 2010

Journal Articles

Unexpected Evidence That Chronic IGF-1 Deficiency In Laron Dwarf Mice Maintains High Levels of Hematopoietic Stem Cells (HSCs) In BM - Are HSCs Gradually Depleted From BM with Age In An IGF-1–dependent Manner? Implications for the Novel Effect of Caloric Restriction on the Hematopoietic Stem Cell Compartment and Longevity.

Janina Ratajczak, MD, PhD, Wu Wan, MS, Rui Liu, MB, BS, Dong-Myung Shin, Ph.D., Magdalena Kucia, PhD, Andrzej Bartke, Ph.D., Mariusz Z Ratajczak, MD, PhD, DSc

Blood (2010) 116 (21): 1551.

https://doi.org/10.1182/blood.V116.21.1551.1551

Published: 2010

Journal Articles

Polycomb Group Protein-Mediated Bivalent Domains Regulate Pluripotency of Oct4 + Very Small Embryonic-Like (VSEL) Stem Cells In Adult Bone Marrow

Dong-Myung Shin, Ph.D., Rui Liu, MB, BS, Wu Wan, MS, Janina Ratajczak, MD, PhD, Mariusz Z Ratajczak, MD, PhD, DSc, Magdalena Kucia, PhD

Blood (2010) 116 (21): 4788.

https://doi.org/10.1182/blood.V116.21.4788.4788

Published: 2010

Journal Articles

Why some cells are “more equal” than others?

Mariusz Z. Ratajczak, Dong-Myung Shin

Blood (2009) 114 (24): 4913–4914.

https://doi.org/10.1182/blood-2009-10-246611

Published: 2009

Journal Articles

Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) – Novel Supporting Evidence for An Existence of Developmentally Distinct Mobile Pool of Oct-4 + Pluripotent Stem Cells in Embryonic and Adult Tissues: Emerging Concept for a Potential 4 th Migratory Germ Layer.

Mariusz Z Ratajczak, MD, PhD, Dong-Myung Shin, PhD, Ewa Zuba-Surma, PhD, Rui Liu, MD, Momoko Yoshimoto, MD, PhD, Mervin C. Yoder, MD, Magdalena Kucia, Ph.D.

Blood (2009) 114 (22): 1480.

https://doi.org/10.1182/blood.V114.22.1480.1480

Published: 2009

Journal Articles

Quiescent Status of Very Small Embryonic Like Stem Cells (VSELs) Points to Pivotal Role of Autocrine Role of Insulin-Like Growth Factor-2 (Igf2) – Ras-Activating Guanine Nucleotide Exchange Factor (Rasgrf1) Axis in Regulating Proliferation of Embryonic Stem Cells.

Izabela Klich, Ph.D., Maciek Tarnowski, Ph.D., Dong-Myung Shin, Ph.D., Janina Ratajczak, M.D.,Ph.D., Magdalena Kucia, PhD, Mariusz Z Ratajczak, MD, PhD

Blood (2009) 114 (22): 1484.

https://doi.org/10.1182/blood.V114.22.1484.1484

Published: 2009

Journal Articles

Genetic and Epigenetic Studies Reveal That Murine Oct-4 + Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) Present in Adult Tissues Share Several Similarities/Markers with Epiblast-Derived Migratory Primordial Germ Cells (PGCs).

Dong-Myung Shin, PhD, Ewa Zuba-Surma, PhD, Rui Liu, M.D., Mariusz Z Ratajczak, MD, PhD, Magdalena Kucia, Ph.D.

Blood (2009) 114 (22): 2521.

https://doi.org/10.1182/blood.V114.22.2521.2521

Published: 2009

Journal Articles

The Unique Pattern of Somatic Imprint in Oct-4 + Very Small Embryonic Like (VSEL) Stem Cells Isolated from Adult Tissues Further Supports Both Their Epiblast/Germ Line Origin and Explains Quiescent Status: Potential Modification of Somatic Imprint as a Key to Longevity?

Dong-Myung Shin, Ph.D., Ewa K Zuba-Surma, Ph.D., Mariusz Z Ratajczak, M.D., Ph.D., Magdalena Kucia

Blood (2008) 112 (11): 385.

https://doi.org/10.1182/blood.V112.11.385.385

Published: 2008

NARROW

New Molecular Evidence That Oct-4 Is Truly Expressed In a Rare Population Of Developmental Early Stem Cells In Human Umbilical Cord Blood (UCB) and That Epigenetic Modification Of Imprinting At Igf2-H19 Locus Regulates Their Quiescent State – Potential Implications For Regenerative Medicine

Challenging Dogmas - Or How Much Evidence Is Necessary To Claim That There Is a Direct Developmental and Functional Link Between The Primordial Germ Cell (PGC) Lineage and Hematopoiesis?

Most Primitive Murine Bone Marrow Hematopoietic Stem Cells Express Several Primordial Germline Cells (PGCs) Markers, Including SALL4 - a Proposed Developmental Link Between Hematopoietic and Primordial Germ Cell Lineages

The Number of Very Small Embryonic Like Stem Cells (VSELs) Decreases During Aging In An IGF-1-Dependent Manner - a Novel Link Between Aging, Caloric Restriction, and the Size of the Stem Cell Pool

Polycomb Group Protein-Mediated Bivalent Domains Regulate Pluripotency of Oct4 + Very Small Embryonic-Like (VSEL) Stem Cells In Adult Bone Marrow

Why some cells are “more equal” than others?

Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) – Novel Supporting Evidence for An Existence of Developmentally Distinct Mobile Pool of Oct-4 + Pluripotent Stem Cells in Embryonic and Adult Tissues: Emerging Concept for a Potential 4 th Migratory Germ Layer.

Quiescent Status of Very Small Embryonic Like Stem Cells (VSELs) Points to Pivotal Role of Autocrine Role of Insulin-Like Growth Factor-2 (Igf2) – Ras-Activating Guanine Nucleotide Exchange Factor (Rasgrf1) Axis in Regulating Proliferation of Embryonic Stem Cells.

Genetic and Epigenetic Studies Reveal That Murine Oct-4 + Very Small Embryonic/Epiblast-Like Stem Cells (VSELs) Present in Adult Tissues Share Several Similarities/Markers with Epiblast-Derived Migratory Primordial Germ Cells (PGCs).

The Unique Pattern of Somatic Imprint in Oct-4 + Very Small Embryonic Like (VSEL) Stem Cells Isolated from Adult Tissues Further Supports Both Their Epiblast/Germ Line Origin and Explains Quiescent Status: Potential Modification of Somatic Imprint as a Key to Longevity?

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American Society of Hematology

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ASH Publications

American Society of Hematology

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