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Eduard J. van Beers, MD
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Journal Articles

Characterization of the Severe Phenotype of Pyruvate Kinase Deficiency

Hanny Al-Samkari, MD, Eduard J. van Beers, MD PhD, D Holmes Morton, MD, Wilma Barcellini, MD, Stefan W. Eber, MD, Bertil Glader, MD PhD, Hassan M. Yaish, MD, Satheesh Chonat, MD, Kevin H. M. Kuo, MDMSc,FRCPC, Nina Kollmar, MD, Jenny M. Despotovic, DO, MS, Dagmar Pospisilova, Prof MD PhD, Christine M. Knoll, MD, Janet L. Kwiatkowski, MD MSCE, Yves D. Pastore, MD, Alexis A. Thompson, MD MPH, Marcin W. Wlodarski, MD PhD, Yaddanapudi Ravindranath, MBBS, Jennifer A. Rothman, MD, Heng Wang, MD PhD, Suzanne Holzhauer, MD MSc, Vicky R. Breakey, BSc,MDFRCPC, Madeleine M. Verhovsek, MD FRCPC, Joachim B. Kunz, MD, Sujit Sheth, MD, Mukta Sharma, MD MPH, Melissa J. Rose, DO, Heather Bradeen, Melissa A. McNaull, MD, Kathryn Addonizio, BS, Hasan Al-Sayegh, Wendy B. London, PhD, Rachael F. Grace, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 949.
https://doi.org/10.1182/blood-2019-125352
Published: 2019
Journal Articles

A Unique Monocyte Transcriptome Discriminates Sickle Cell Disease from Other Hereditary Hemolytic Anemias and Shows the Particular Importance of Lipid and Interferon Signaling

Annelies J. Van Vuren, MD, Stephanie van Straaten, MD PhD, Michal Mokry, PhD, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 980.
https://doi.org/10.1182/blood-2019-124070
Published: 2019
Journal Articles

Comorbidities and Complications in Adults with Pyruvate Kinase Deficiency

Audra N. Boscoe, PhD, Yan Yan, MS, Elizabeth Hedgeman, PhD, Eduard J. van Beers, MD PhD, Hanny Al-Samkari, MD, Wilma Barcellini, MD, Stefan W. Eber, MD, Bertil Glader, MD PhD, Hassan M. Yaish, MD, Satheesh Chonat, MD, Jennifer A. Rothman, MD, Mukta Sharma, MD MPH, Nina Kollmar, MD, Christine M. Knoll, MD, Kevin H. M. Kuo, MDMSc,FRCPC, Janet L. Kwiatkowski, MD MSCE, Yves D. Pastore, MD, Alexis A Thompson, MD MPH, Yaddanapudi Ravindranath, MBBS, Ellis J. Neufeld, MD, Heng Wang, MD PhD, Susanne Holzhauer, MD MSc, Vicky R. Breakey, BSc,MDFRCPC, Madeleine M. Verhovsek, MD FRCPC, Joachim B. Kunz, MD, Sujit Sheth, MD, Melissa A. McNaull, MD, Melissa J. Rose, DO, Dagmar Pospisilova, MD PhD, Jenny M. Despotovic, DO, Rachael F. Grace, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2175.
https://doi.org/10.1182/blood-2019-123069
Published: 2019
Journal Articles

Decreased Activity and Stability of Pyruvate Kinase in Hereditary Hemolytic Anemia: A Potential Target for Therapy By AG-348 (Mitapivat), an Allosteric Activator of Red Blood Cell Pyruvate Kinase

Minke A.E. Rab, MD, Brigitte A. van Oirschot, Stephanie van Straaten, MD PhD, Bart J. Biemond, MD PhD, Jennifer Bos, Penelope A. Kosinski, MS, Charles Kung, PhD, Eduard J. van Beers, MD PhD, Richard van Wijk, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3506.
https://doi.org/10.1182/blood-2019-129996
Published: 2019
Journal Articles

Long-Term Safety and Efficacy of Mitapivat (AG-348), a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency: The DRIVE PK Study

Rachael F. Grace, MD, D. Mark Layton, MB BS, FRCP, FRCPCH, Frédéric Galactéros, MD PhD, Wilma Barcellini, MD, Eduard J. van Beers, MD PhD, Hassan M. Yaish, MD, Yaddanapudi Ravindranath, MBBS, Kevin H. M. Kuo, MDMSc,FRCPC, Sujit Sheth, MD, Janet L. Kwiatkowski, MD MSCE, Lei Hua, PhD, Peter F. Hawkins, PhD, Chris Mix, MD, Bertil Glader, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3512.
https://doi.org/10.1182/blood-2019-123406
Published: 2019
Journal Articles

An Ongoing Global, Longitudinal, Observational Study of Patients with Pyruvate Kinase Deficiency: The PEAK Registry

Rachael F. Grace, MD, Paola Bianchi, BSc, PhD, Bertil Glader, MD PhD, Andreas Glenthøj, MD PhD, Bryan Jones, PhD, Hitoshi Kanno, MD PhD, Kevin H. M. Kuo, MDMSc,FRCPC, D. Mark Layton, MB ChB, Eduard J. van Beers, MD PhD, Joan-Lluis Vives Corrons, MD PhD, Tu Xu, MS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2223.
https://doi.org/10.1182/blood-2019-123059
Published: 2019
Journal Articles

Lactate Dehydrogenase to Carboxyhemoglobin Ratio As a Biomarker of Heme Release to Heme Processing Is Associated with Higher Tricuspid Regurgitant Jet Velocity and Early Death in Sickle Cell Disease

Annelies J. Van Vuren, MD, Laurel Mendelsohn, BS, Richard van Wijk, PhD, Caterina P. Minniti, MD, John Baird, MD, Gregory J Kato, MD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2274.
https://doi.org/10.1182/blood-2019-124048
Published: 2019
Journal Articles

The Oxygenscan Provides Clinically Relevant Biomarkers for Treatment Efficacy That Are Associated with Frequency of Vaso-Occlusive Crisis in Sickle Cell Disease

Minke A.E. Rab, MD, Richard van Wijk, PhD, Celeste K. Kanne, BA, Brigitte A. van Oirschot, Jennifer Bos, Camille Boisson, Maite E. Houwing, MD, Jorn J. Gerritsma, MD, Karin Fijnvandraat, MD PhD, Celine Renoux, PhD, Marije Bartels, MD PhD, Erfan Nur, MD PhD, Marjon H. Cnossen, MD PhD, Philippe Joly, PhD, Romain Fort, MD, Philippe Connes, PhD, Eduard J. van Beers, MD PhD, Vivien A. Sheehan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2275.
https://doi.org/10.1182/blood-2019-128870
Published: 2019
Journal Articles

Erythropoietin Is Associated with a Decline in the iFGF23/cFGF23 Ratio in Patients with Various Hereditary Hemolytic Anemias

Annelies J. Van Vuren, MD, Michele F. Eisenga, MD PhD, Stephanie van Straaten, MD PhD, Andreas Glenthøj, MD PhD, Carlo A.J.M. Gaillard, MD PhD, Stephan J.L. Bakker, MD PhD, Martin H. de Borst, MD PhD, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4793.
https://doi.org/10.1182/blood-2019-124074
Published: 2019
Journal Articles

Mitapivat (AG-348) in Adults with Pyruvate Kinase Deficiency Who Are Not Regularly Transfused: A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled Study (ACTIVATE) in Progress

Eduard J. van Beers, MD PhD, Malia P. Judge, BS, RN, Lei Hua, PhD, Chris Mix, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4791.
https://doi.org/10.1182/blood-2019-123100
Published: 2019
Journal Articles

Proton Pump Inhibition for Secondary Hemochromatosis in Hereditary Anemia, a Phase III Placebo Controlled Randomized Cross-over Trial in Progress

Annelies J. Van Vuren, MD, Bart J. Biemond, MD PhD, Jean-Louis Kerkhoffs, MD PhD, Saskia E.M. Schols, MD PhD, A. W. Rijneveld, MD PhD, Erfan Nur, MD PhD, Richard van Wijk, PhD, Tim Leiner, MD PhD, Joannes J.M. Marx, Emeritus Professor, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 960.
https://doi.org/10.1182/blood-2019-124059
Published: 2019
Journal Articles

Untargeted Metabolomics on Dried Blood Spots for the Diagnosis and Clinical Follow up of Rare Hereditary Anemias

Birgit van Dooijeweert, MD, Melissa Broeks, Msc, Judith Jans, PhD, Eduard J. van Beers, MD PhD, Nanda Verhoeven, PhD, Richard van Wijk, PhD, Marije Bartels, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3376.
https://doi.org/10.1182/blood-2019-131693
Published: 2019
Journal Articles

The Oxygenscan: A Rapid and Reproducible Test to Determine Patient-Specific, Clinically Relevant Biomarkers of Disease Severity in Sickle Cell Anemia

Minke A.E, Rab, MD, Celeste K Kanne, BA, Brigitte A. van Oirschot, Jennifer F. Bos, Maite Elizabeth Houwing, MD, Marjon H. Cnossen, MD PhD, Roger Schutgens, MD PhD MSc, Gerard Pasterkamp, MD PhD, Richard van Wijk, PhD, Vivien A Sheehan, MD PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2360.
https://doi.org/10.1182/blood-2018-99-112930
Published: 2018
Journal Articles

Striking Difference in Iron Utilization between Oral and Intravenous Iron in Various Anemias and Hemochromatosis

Annelies J. Van Vuren, MD, Joannes J.M. Marx, Emeritus Professor, Richard van Wijk, PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2338.
https://doi.org/10.1182/blood-2018-99-113030
Published: 2018
Journal Articles

Health Related Quality of Life and Fatigue in Patients with Pyruvate Kinase Deficiency

Eduard J. Van Beers, MD PhD, Kevin H. M. Kuo, MD MSc, FRCPC, D. Holmes Morton, MD, Wilma Barcellini, MD, Stefan W. Eber, MD, Bertil Glader, MD, Hassan M. Yaish, MD, Satheesh Chonat, MD, Nina Kollmar, MD, Jenny M. Despotovic, DO, MS, Dagmar Pospisilova, Prof. MD PhD, Christine M. Knoll, MD, Janet L. Kwiatkowski, MD, Yves D. Pastore, MD, Alexis A. Thompson, MD MPH, Winfred Wang, MD, Marcin W. Wlodarski, MD PhD, Peter E. Newburger, MD, Yaddanapudi Ravindranath, MBBS, Jennifer A. Rothman, MD, Heng Wang, MD PhD, Suzanne Holzhauer, MD MSc, Vicky R. Breakey, BSc, MD FRCPC, Madeleine M Verhovsek, MD FRCPC, Joachim B. Kunz, MD, Sujit Sheth, MD, Mukta Sharma, MD MPH, Melissa J. Rose, DO, Heather A. Bradeen, MD, Melissa A. McNaull, MD, Kathryn Addonizio, BA, David N Williams, Rachael F. Grace, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4807.
https://doi.org/10.1182/blood-2018-99-113206
Published: 2018
Journal Articles

Phosphatidylserine-Exposing Extracellular Vesicles after Splenectomy Are Associated with Increased D-Dimers and Fibrin Generation in Hereditary Hemolytic Anemia

Stephanie Van Straaten, MD, Chi Hau, Najat Hajji, Jill Verhoeven, Roger Schutgens, MD PhD MSc, Wouter van Solinge, PhD, Richard van Wijk, PhD, Rienk Nieuwland, PhD, Eduard J. van Beers, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 630.
https://doi.org/10.1182/blood-2018-99-110918
Published: 2018
Journal Articles

Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2

Mohsin Badat, MBBChir, James O.J. Davies, PhD, Eduard J. van Beers, MD PhD, Cornelis Harteveld, PhD, Damien Downes, PhD, Douglas R. Higgs, FRS
Journal: Blood
Blood (2018) 132 (Supplement 1): 3632.
https://doi.org/10.1182/blood-2018-99-116209
Published: 2018
Journal Articles

Genotype-Phenotype Correlation and Molecular Heterogeneity in Pyruvate Kinase Deficiency: Data from the PKD Natural History Study

Paola Bianchi, BSc, PhD, Elisa Fermo, PhD, Kimberly Lezon-Geyda, PhD, Patrick G. Gallagher, MD, Richard van Wijk, PhD, Eduard J. Van Beers, MD, Hassan M. Yaish, MD, Janet L. Kwiatkowski, MD, Peter E. Newburger, MD, Yaddanapudi Ravindranath, MBBS, Oliver Andres, MD, Wilma Barcellini, MD, D. Holmes Morton, MD, Bertil Glader, MD, Stefan W. Eber, MD, Satheesh Chonat, MD, Nina Kollmar, MD, Jenny M. Despotovic, DO, MS, Christine M. Knoll, MD, Kevin H.M. Kuo, MD MSc, FRCPC, Dagmar Pospisilova, Prof. MD PhD, Yves D. Pastore, MD, Alexis A Thompson, MD MPH, Winfred Wang, MD, Marcin W. Wlodarski, MD PhD, Jennifer A. Rothman, MD, Heng Wang, MD PhD, Suzanne Holzhauer, MD MSc, Vicky R. Breakey, BSc,MDFRCPC, Joachim B. Kunz, MD, Sujit Sheth, MD, Mukta Sharma, MD MPH, Melissa J. Rose, DO, Heather A. Bradeen, MD, Melissa N. McNaull, MD, Gabrielle P. Ooyama, Nolan Neu, BS, Hasan Al-Sayegh, Wendy B. London, PhD, Rachael F. Grace, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3479.
https://doi.org/10.1182/blood.V130.Suppl_1.3479.3479
Published: 2017
Journal Articles

Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency

Rachael F. Grace, MD, D. Mark Layton, MB, FRCP, Frédéric Galactéros, MDPhD, Christian Rose, MD, Wilma Barcellini, MD, D. Holmes Morton, MD, Eduard J. Van Beers, MD, Hassan M. Yaish, MD, Yaddanapudi Ravindranath, MBBS, Kevin H.M. Kuo, MD MSc, FRCPC, Sujit Sheth, MD, Janet L. Kwiatkowski, MD, Bruce Silver, MD, Charles Kung, Marvin Cohen, Hua Yang, Penelope A. Kosinski, MS, Lei Hua, Ann Barbier, Bertil Glader, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2194.
https://doi.org/10.1182/blood.V130.Suppl_1.2194.2194
Published: 2017
Journal Articles

Iron Overload Is Highly Prevalent in All Disease Severity States in Pyruvate Kinase Deficiency (PKD)

Eduard J van Beers, MD PhD, Wilma Barcellini, Stefan W. Eber, MD, Janet L Kwiatkowski, MD, Jennifer A Rothman, MD, Ellis J Neufeld, MD PhD, Mukta Sharma, MD MPH, D Holmes Morton, MD, Bertil Glader, MD PhD, Nina Kollmar, MD, Hassan M. Yaish, Jenny M. Despotovic, DO, MS, Christine M. Knoll, MD, Yves D. Pastore, MD, Kevin Kuo, BSc, MD, Peter E. Newburger, MD, Marcin W Wlodarski, MD, Alexis A. Thompson, MD MPH, Yaddanapudi Ravindranath, Winfred C. Wang, MD, Heng Wang, MD, Joachim B. Kunz, MD, Vicky R. Breakey, BSc, MD MD FRCPC, Melissa J. Rose, DO, Melissa Rhodes, MD, Heather A Bradeen, MD, Sujit Sheth, MD, Dongjing Guo, MS, Wendy B. London, PhD, Rachael F. Grace, MD
Journal: Blood
Blood (2016) 128 (22): 2430.
https://doi.org/10.1182/blood.V128.22.2430.2430
Published: 2016