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Journal Articles

Application of a Validated Method for Quantifying Circulating Protoporphyrin IX to the Beacon Trial of Bitopertin in Erythropoietic Protoporphyria

Heidi Mangus, George Mensing, William Savage, Melanie Chin, Yue Chen, Guowen Liu, Hua Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 5228.
https://doi.org/10.1182/blood-2023-178122
Published: 2023
Journal Articles

Anti-Hemojuvelin Monoclonal Antibody DISC-0974 Elicits a Durable and Consistent Response with Repeated Dosing in Cynomolgus Monkeys

Scott A Reisman, William Savage, Guowen Liu, Hua Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 5224.
https://doi.org/10.1182/blood-2023-179470
Published: 2023
Journal Articles

Efficacy and Safety of Axicabtagene Ciloleucel (Axi-cel) for the Treatment of Relapse/Refractory Non-Hodgkin Lymphoma: Real-World Data in Chinese Population

Zixun Yan, Dehui Zou, Yuhua Li, Xiaojian Zhu, Dongmei Ji, Wenbin Qian, Ying Lu, Chunyan Ji, Keshu Zhou, Hongmei Jing, Hua Yang, Lanfang Li, Fei Li, Kailin Xu, Ting Niu, Depei Wu, Yu Hu, Weili Zhao
Journal: Blood
Blood (2023) 142 (Supplement 1): 6928.
https://doi.org/10.1182/blood-2023-181351
Published: 2023
Journal Articles

DISC-0974, an Anti-Hemojuvelin Antibody, Reduces Hepcidin and Mobilizes Iron in Healthy Volunteers

Natasha Novikov, Akshay Buch, Hua Yang, Sarah Tuller, Michelle Andruk, Katherine Chan, Min Wu, Richard Rodriguez, Rajiv Panwar, Haley Howell, Brian MacDonald, Will Savage
Journal: Blood
Blood (2022) 140 (Supplement 1): 5339–5340.
https://doi.org/10.1182/blood-2022-167870
Published: 2022
Journal Articles

Preclinical Pharmacokinetics and Pharmacodynamics of DISC-0998, a Humanized Anti-Hemojuvelin (HJV) Monoclonal Antibody to Suppress the Production of Hepcidin

Yue Chen, Will Savage, Rajiv Panwar, Richard Rodriguez, Min Wu, John Quisel, Hua Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 8184–8185.
https://doi.org/10.1182/blood-2022-168985
Published: 2022
Journal Articles

Risk and Prognostic Factors for Intracranial Hemorrhage in Elderly Patients with Immune Thrombocytopenia

Jia-Ning Zhang, Peng Zhao, Kaiyan Liu, Ming Hou, Yanqiu Han, PhD, Jian-Da Hu, PhD, Ze-Ping Zhou, Xin Wang, MDPhD, Ru Feng, Lin-Hua Yang, MD, He-Bing Zhou, Tie-nan Zhu, MD, Ye Jun Wu, Xiao-Hui Zhang
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-136461
Published: 2020
Journal Articles

Population Pharmacokinetics of Ivosidenib (AG-120) in Patients with IDH1-Mutant Advanced Hematologic Malignancies

Kha Le, PhD, Russ Wada, PhD, David Dai, PhD, Bin Fan, PhD, Guowen Liu, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Samuel V. Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1394.
https://doi.org/10.1182/blood-2018-99-109863
Published: 2018
Journal Articles

Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency

Rachael F. Grace, MD, D. Mark Layton, MB, FRCP, Frédéric Galactéros, MDPhD, Christian Rose, MD, Wilma Barcellini, MD, D. Holmes Morton, MD, Eduard J. Van Beers, MD, Hassan M. Yaish, MD, Yaddanapudi Ravindranath, MBBS, Kevin H.M. Kuo, MD MSc, FRCPC, Sujit Sheth, MD, Janet L. Kwiatkowski, MD, Bruce Silver, MD, Charles Kung, Marvin Cohen, Hua Yang, Penelope A. Kosinski, MS, Lei Hua, Ann Barbier, Bertil Glader, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2194.
https://doi.org/10.1182/blood.V130.Suppl_1.2194.2194
Published: 2017
Journal Articles

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Charles Kung, Jeff Hixon, Penelope A. Kosinski, Giovanni Cianchetta, Gavin Histen, Yue Chen, Collin Hill, Stefan Gross, Yaguang Si, Kendall Johnson, Byron DeLaBarre, Zhiyong Luo, Zhiwei Gu, Gui Yao, Huachun Tang, Cheng Fang, Yingxia Xu, Xiaobing Lv, Scott Biller, Shin-San Michael Su, Hua Yang, Janeta Popovici-Muller, Francesco Salituro, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2017) 130 (11): 1347–1356.
https://doi.org/10.1182/blood-2016-11-753525
Published: 2017
Includes: Supplemental data
Journal Articles

Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study

Rachael F Grace, MD, Christian Rose, D Mark Layton, Hassan M Yaish, Wilma Barcellini, Frédéric Galactéros, D Holmes Morton, Yaddanapudi Ravindranath, Kevin H.M. Kuo, MD MSc, FRCPC, Eduard J van Beers, Janet L Kwiatkowski, Bruce A Silver, Elizabeth Merica, Charles Kung, Marvin Cohen, Hua Yang, Jeffrey Hixon, Penelope A Kosinski, Lee Silverman, Lenny Dang, Zheng (Jason) Yuan, Ann J Barbier, Bertil Glader
Journal: Blood
Blood (2016) 128 (22): 402.
https://doi.org/10.1182/blood.V128.22.402.402
Published: 2016
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-519, a Pyruvate Kinase Activator for the Treatment of Pyruvate Kinase Deficiency, in Human Healthy Volunteers

Kha Le, Marvin Cohen, Ann J Barbier, Elizabeth Merica, Charles Kung, Penelope A Kosinski, Scott Biller, Hua Yang
Journal: Blood
Blood (2016) 128 (22): 1263.
https://doi.org/10.1182/blood.V128.22.1263.1263
Published: 2016
Journal Articles

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of AG-519, an Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Ann J Barbier, Susan Bodie, Gary Connor, Elizabeth Merica, Charles Kung, Kha Le, Hua Yang, Penelope A Kosinski, Lee Silverman, Zheng (Jason) Yuan, Chris Bowden, Marvin Cohen
Journal: Blood
Blood (2016) 128 (22): 1264.
https://doi.org/10.1182/blood.V128.22.1264.1264
Published: 2016
Journal Articles

Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies

Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Liu, Malia Prahl, Chris J Bowden, Scott Biller, Sam Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 1310.
https://doi.org/10.1182/blood.V126.23.1310.1310
Published: 2015
Journal Articles

Evaluation of the Pharmacokinetics of AG-221, a Potent Mutant IDH2 Inhibitor, in Patients with IDH2-Mutation Positive Advanced Hematologic Malignancies in a Phase 1/2 Trial

Yue Gao, PhD, Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Yang, PhD, Katherine Yen, PhD, Sam Agresta, MD, Eyal C. Attar, MD, Jian Chen, PhD, Qiang Xu, PhD, Alessandra Tosolini, BS, Jay M. Mei, MD PhD, Anjan Thakurta, Robert D. Knight, MD, Yan Li, PhD
Journal: Blood
Blood (2015) 126 (23): 2509.
https://doi.org/10.1182/blood.V126.23.2509.2509
Published: 2015
Journal Articles

Chimeric Antigen Receptor 4SCAR19-Modified T Cells in Acute Lymphoid Leukemia: a Phase II Multi-Center Clinical Trial in China

Lujia Dong, MD, Lung-Ji Chang, PhD, Zhiyong Gao, MD, Dao-Pei Lu, MD, Jian-Ping Zhang, MD, Jing-Bo Wang, MD, Le-Ping Zhang, MD, Yu-Hong Chen, MD, Hu-Yong Zheng, MD, Ting Liu, Ting Niu, MD PhD, He Huang, MD PhD, Rong Liu, MD, Heng-Xiang Wang, MD, Li Gao, MD, Tong-Hua Yang, MD, Xun Lai, MD
Journal: Blood
Blood (2015) 126 (23): 3774.
https://doi.org/10.1182/blood.V126.23.3774.3774
Published: 2015
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

DRIVE PK: A Phase 2 Trial of AG-348 in Patients with Pyruvate Kinase Deficiency

Ann Barbier, Bruce Silver, Elizabeth Merica, Marvin Cohen, Charles Kung, Hua Yang, PhD, Rachael F. Grace, MD, Bertil Glader, MD PhD, Sam Agresta, MD
Journal: Blood
Blood (2015) 126 (23): 4548.
https://doi.org/10.1182/blood.V126.23.4548.4548
Published: 2015
Journal Articles

Clonal Evolution Paths Significantly Impact the Outcome of Myeloma

Xiaoqi Qin, MD, Gang An, MDPhD, Lin-ping Hu, MD, Yu Qin, MD PhD, Yan Xu, MDPhD, Xiaoyan Feng, Meirong Zang, Shuhui Deng, MD PhD, Weiwei Sui, MD, Shuhua Yi, MD PhD, Zengjun Li, Sr., Lin-hua Yang, MD, Tao Cheng, MD, Jianxiang Wang, MD, Lugui Qiu, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1784.
https://doi.org/10.1182/blood.V126.23.1784.1784
Published: 2015
Journal Articles

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

Andrew Kernytsky, Fang Wang, Erica Hansen, Stefanie Schalm, Kimberly Straley, Camelia Gliser, Hua Yang, Jeremy Travins, Stuart Murray, Marion Dorsch, Sam Agresta, David P. Schenkein, Scott A. Biller, Shinsan M. Su, Wei Liu, Katharine E. Yen
Journal: Blood
Blood (2015) 125 (2): 296–303.
https://doi.org/10.1182/blood-2013-10-533604
Published: 2015
Includes: Supplemental data
Journal Articles

Exome Sequencing Identifies Somatic Mutations of DDX3X in Natural Killer/T-Cell Lymphoma

Lu Jiang, PhD, Zhao-Hui Gu, PhD, Zi-Xun Yan, PhD, Xia Zhao, MD, Yin-Yin Xie, PhD, Zi-Guan Zhang, B.S., Chun-Ming Pan, M.S., Yuan Hu, MD, Chang-Ping Cai, MD, Ying Dong, MD, Li Wang, MD, Yang Shen, MD, Guoyu Meng, PhD, Jian-Feng Zhou, MD, PhD, Jian-Da Hu, MD, PhD, Jin-Fen Wang, MD, Lin-Hua Yang, MD, Feng Zhang, MD, Jian-Min Wang, MD, Zhao Wang, MD, Zhi-Gang Peng, MD, Fang-Yuan Chen, MD, Zi-Min Sun, MD, Hao Ding, MD, Jin-Yan Huang, PhD, Yuan-Hua Liu, MD, Jumei Shi, MD, PhD, Jian Hou, MD, Jin-Song Yan, MD, PhD, Jing-Yi Shi, PhD, Lan Xu, PhD, Yang Li, MD, Jing Lu, B.S., Zhong Zheng, MD, Wen Xue, B.S., Wei-Li Zhao, MD, PhD, Zhu Chen, MD, PhD, Sai-Juan Chen, MD, PhD
Journal: Blood
Blood (2014) 124 (21): 1663.
https://doi.org/10.1182/blood.V124.21.1663.1663
Published: 2014