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Penelope Kosinski
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Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Hua Yang, Elizabeth Merica, Yue Chen, Marvin Cohen, Ronald Goldwater, Collin Hill, Hyeryun Kim, Penelope Kosinski, Charles Kung, Bruce Silver, Luke Utley, Sam Agresta
Journal: Blood
Blood (2014) 124 (21): 4007.
https://doi.org/10.1182/blood.V124.21.4007.4007
Published: 2014
Journal Articles

AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice

Charles Kung, Collin Hill, Yue Chen, Abhishek Jha, Penelope Kosinski, Michelle Clasquin, Yaguang Si, Hyeryun Kim, Jeff Hixon, Lenny Dang, Sam Agresta, Lee Silverman, Hua Yang
Journal: Blood
Blood (2014) 124 (21): 4010.
https://doi.org/10.1182/blood.V124.21.4010.4010
Published: 2014
Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2013) 122 (21): 2180.
https://doi.org/10.1182/blood.V122.21.2180.2180
Published: 2013