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Yue Chen
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Journal Articles

Application of a Validated Method for Quantifying Circulating Protoporphyrin IX to the Beacon Trial of Bitopertin in Erythropoietic Protoporphyria

Heidi Mangus, George Mensing, William Savage, Melanie Chin, Yue Chen, Guowen Liu, Hua Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 5228.
https://doi.org/10.1182/blood-2023-178122
Published: 2023
Journal Articles

Micheliolide Exerts Therapeutic Effect in Myeloproliferative Neoplasms through Binding to STAT3 and STAT5 Proteins and Inhibiting Their Activities

Huijun Huang, Jinqin Liu, Lin Yang, Yue Chen, Robert Peter Gale, Zhijian Xiao
Journal: Blood
Blood (2022) 140 (Supplement 1): 3065–3066.
https://doi.org/10.1182/blood-2022-165225
Published: 2022
Journal Articles

Preclinical Pharmacokinetics and Pharmacodynamics of DISC-0998, a Humanized Anti-Hemojuvelin (HJV) Monoclonal Antibody to Suppress the Production of Hepcidin

Yue Chen, Will Savage, Rajiv Panwar, Richard Rodriguez, Min Wu, John Quisel, Hua Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 8184–8185.
https://doi.org/10.1182/blood-2022-168985
Published: 2022
Journal Articles

Autologous transplant vs chimeric antigen receptor T-cell therapy for relapsed DLBCL in partial remission

Mazyar Shadman, Marcelo Pasquini, Kwang Woo Ahn, Yue Chen, Cameron J. Turtle, Peiman Hematti, Jonathon B. Cohen, Farhad Khimani, Siddhartha Ganguly, Reid W. Merryman, Jean A. Yared, Frederick L. Locke, Nausheen Ahmed, Pashna N. Munshi, Amer Beitinjaneh, Patrick M. Reagan, Alex F. Herrera, Craig S. Sauter, Mohamed A. Kharfan-Dabaja, Mehdi Hamadani
Journal: Blood
Blood (2022) 139 (9): 1330–1339.
https://doi.org/10.1182/blood.2021013289
Published: 2022
Includes: Supplemental data
Journal Articles

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Charles Kung, Jeff Hixon, Penelope A. Kosinski, Giovanni Cianchetta, Gavin Histen, Yue Chen, Collin Hill, Stefan Gross, Yaguang Si, Kendall Johnson, Byron DeLaBarre, Zhiyong Luo, Zhiwei Gu, Gui Yao, Huachun Tang, Cheng Fang, Yingxia Xu, Xiaobing Lv, Scott Biller, Shin-San Michael Su, Hua Yang, Janeta Popovici-Muller, Francesco Salituro, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2017) 130 (11): 1347–1356.
https://doi.org/10.1182/blood-2016-11-753525
Published: 2017
Includes: Supplemental data
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015
Journal Articles

Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Hua Yang, Elizabeth Merica, Yue Chen, Marvin Cohen, Ronald Goldwater, Collin Hill, Hyeryun Kim, Penelope Kosinski, Charles Kung, Bruce Silver, Luke Utley, Sam Agresta
Journal: Blood
Blood (2014) 124 (21): 4007.
https://doi.org/10.1182/blood.V124.21.4007.4007
Published: 2014
Journal Articles

AG-221, an Oral, Selective, First-in-Class, Potent IDH2-R140Q Mutant Inhibitor, Induces Differentiation in a Xenotransplant Model

Cyril Quivoron, Muriel David, Kim Straley, Jeremy Travins, Hyeryun Kim, Yue Chen, Dongwei Zhu, Véronique Saada, Olivia Bawa, Paule Opolon, Mélanie Polrot, Jean-Baptiste Micol, Christophe Willekens, Olivier Bernard, Hua Yang, Sam Agresta, Stéphane de Botton, Katharine Yen, Virginie Penard-Lacronique
Journal: Blood
Blood (2014) 124 (21): 3735.
https://doi.org/10.1182/blood.V124.21.3735.3735
Published: 2014
Journal Articles

Evaluation of Pharmacokinetic-Pharmacodynamic (PKPD) Relationship of an Oral, Selective, First-in-Class, Potent IDH2 Inhibitor, AG-221, from a Phase 1 Trial in Patients with Advanced IDH2 Mutant Positive Hematologic Malignancies

Bin Fan, Yue Chen, Fang Wang, Katharine Yen, Luke Utley, Caroline Almon, Scott Biller, Sam Agresta, Hua Yang
Journal: Blood
Blood (2014) 124 (21): 3737.
https://doi.org/10.1182/blood.V124.21.3737.3737
Published: 2014
Journal Articles

AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice

Charles Kung, Collin Hill, Yue Chen, Abhishek Jha, Penelope Kosinski, Michelle Clasquin, Yaguang Si, Hyeryun Kim, Jeff Hixon, Lenny Dang, Sam Agresta, Lee Silverman, Hua Yang
Journal: Blood
Blood (2014) 124 (21): 4010.
https://doi.org/10.1182/blood.V124.21.4010.4010
Published: 2014
Journal Articles

Antitumor Efficacy Of DMSA Modified Fe 3 O 4 magnetic Nanoparticles Combined With Arsenic Trioxide and Adriamycin In Jurket Cells

Cai Xiaohui, Chunling Wang, Baoan Chen, PHD, Professor, Weijun Hua, Fei Shen, Liang Yu, PHD, Zhengmei He, Yue Chen, Guohua Xia, Jian Cheng, PhD,, Wen Bao, Yu Zhang, PHD, Xuemei Wang, PHD, Senthilkumar Ravichandran
Journal: Blood
Blood (2013) 122 (21): 4917.
https://doi.org/10.1182/blood.V122.21.4917.4917
Published: 2013
Journal Articles

IDH1 Mutant Inhibitor Induces Cellular Differentiation and Offers a Combination Benefit With Ara-C In a Primary Human Idh1 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Rene Lemieux, Ph.D., Janeta Popovici-Muller, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, Samuel Agresta, MD, David P. Schenkein, MD, Scott Biller, Michael Su, Fang Wang
Journal: Blood
Blood (2013) 122 (21): 3946.
https://doi.org/10.1182/blood.V122.21.3946.3946
Published: 2013
Journal Articles

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Charles Kung, Ph.D., Jeff Hixon, Penelope Kosinski, Gavin Histen, Collin Hill, Yaguang Si, Andrew Kernytsky, Yue Chen, Ph.D., Byron DeLaBarre, Michelle Clasquin, Helen Ho, Furha I. Cossor, MD MS, Ellis J. Neufeld, MD, PhD, Frank Salituro, Janeta Popovici-Muller, Samuel Agresta, MD, Lee Silverman, Lenny Dang
Journal: Blood
Blood (2013) 122 (21): 2180.
https://doi.org/10.1182/blood.V122.21.2180.2180
Published: 2013
Journal Articles

AG-221 Offers a Survival Advantage In a Primary Human IDH2 Mutant AML Xenograft Model

Katharine Yen, Ph.D., Fang Wang, Jeremy Travins, Yue Chen, Ph.D., Hua Yang, Kim Straley, Sung Choe, Marion Dorsch, David P. Schenkein, MD, Samuel Agresta, MD, Scott Biller, Michael Su
Journal: Blood
Blood (2013) 122 (21): 240.
https://doi.org/10.1182/blood.V122.21.240.240
Published: 2013