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Journal Articles

Population Pharmacokinetics of Ivosidenib (AG-120) in Patients with IDH1-Mutant Advanced Hematologic Malignancies

Kha Le, PhD, Russ Wada, PhD, David Dai, PhD, Bin Fan, PhD, Guowen Liu, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Samuel V. Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1394.
https://doi.org/10.1182/blood-2018-99-109863
Published: 2018
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-519, a Pyruvate Kinase Activator for the Treatment of Pyruvate Kinase Deficiency, in Human Healthy Volunteers

Kha Le, Marvin Cohen, Ann J Barbier, Elizabeth Merica, Charles Kung, Penelope A Kosinski, Scott Biller, Hua Yang
Journal: Blood
Blood (2016) 128 (22): 1263.
https://doi.org/10.1182/blood.V128.22.1263.1263
Published: 2016
Journal Articles

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of AG-519, an Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects

Ann J Barbier, Susan Bodie, Gary Connor, Elizabeth Merica, Charles Kung, Kha Le, Hua Yang, Penelope A Kosinski, Lee Silverman, Zheng (Jason) Yuan, Chris Bowden, Marvin Cohen
Journal: Blood
Blood (2016) 128 (22): 1264.
https://doi.org/10.1182/blood.V128.22.1264.1264
Published: 2016
Journal Articles

Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies

Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Liu, Malia Prahl, Chris J Bowden, Scott Biller, Sam Agresta, MD, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 1310.
https://doi.org/10.1182/blood.V126.23.1310.1310
Published: 2015
Journal Articles

Evaluation of the Pharmacokinetics of AG-221, a Potent Mutant IDH2 Inhibitor, in Patients with IDH2-Mutation Positive Advanced Hematologic Malignancies in a Phase 1/2 Trial

Yue Gao, PhD, Bin Fan, PhD, Kha Le, PhD, Erika Manyak, BASc, Hua Yang, PhD, Katherine Yen, PhD, Sam Agresta, MD, Eyal C. Attar, MD, Jian Chen, PhD, Qiang Xu, PhD, Alessandra Tosolini, BS, Jay M. Mei, MD PhD, Anjan Thakurta, Robert D. Knight, MD, Yan Li, PhD
Journal: Blood
Blood (2015) 126 (23): 2509.
https://doi.org/10.1182/blood.V126.23.2509.2509
Published: 2015
Journal Articles

Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency

Kha Le, PhD, Marvin Cohen, Yue Chen, Hyeryun Kim, Bruce Silver, Sam Agresta, MD, Elizabeth Merica, Charles Kung, Penelope Kosinski, Lee Silverman, Scott Biller, Hua Yang, PhD
Journal: Blood
Blood (2015) 126 (23): 3336.
https://doi.org/10.1182/blood.V126.23.3336.3336
Published: 2015