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Journal Articles

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-138900

Published: 2020

Journal Articles

IKZF3 Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia

Shanye Yin, PhD, Gregory Lazarian, PharmD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, PhD, Satyen Gohil, BSc, MBBS, MRCP, FRCPath, Shuqiang Li, PhD, Laura Z. Rassenti, PhD, Leah Billington, BA, Elizabeth Witten, Teddy Huang, BS, Kenneth J. Livak, PhD, Donna S. Neuberg, ScD, Fanny Baran-Marszak, MD PhD, Thomas J. Kipps, MD PhD, Florence Cymbalista, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-137085

Published: 2020

Journal Articles

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-137130

Published: 2020

Journal Articles

Expression of Sf3b1-K700E accelerates the Development of Chronic Lymphocytic Leukemia in a Del (13q) Murine Model

Bo Zhang, MDPhD, Prajish Iyer, PhD, Meiling Jin, PhD, Elisa Ten Hacken, PhD, Zachary Cartun, BS, Kevyn Hart, BS, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD PhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD, Lili Wang, MDPhD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-139096

Published: 2020

Journal Articles

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Gregory Lazarian, PharmD, Shanye Yin, PhD, Elisa Ten Hacken, PhD, Tomasz Sewastianik, MSc,PhD, Alba Font-tello, PhD, Heather Joyal, Elizabeth Witten, Mei Zheng, Christopher J. Ott, PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2019) 134 (Supplement_1): 848.

https://doi.org/10.1182/blood-2019-123963

Published: 2019

Journal Articles

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

Blood (2019) 134 (Supplement_1): 684.

https://doi.org/10.1182/blood-2019-127673

Published: 2019

Journal Articles

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Blood (2019) 134 (Supplement_1): 1284.

https://doi.org/10.1182/blood-2019-131336

Published: 2019

Journal Articles

Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL

Shanye Yin, PhD, Salma Parvin, PhD, Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Heather Joyal, Laura Z. Rassenti, PhD, Emanuela M. Ghia, PhD, Thomas J. Kipps, MD PhD, Donna S Neuberg, ScD, Lili Wang, MD PhD, Matthew S. Davids, MD, Ruben D. Carrasco, MD PhD, Anthony G. Letai, MD PhD, Catherine J. Wu, MD

Blood (2019) 134 (Supplement_1): 4281.

https://doi.org/10.1182/blood-2019-127293

Published: 2019

Journal Articles

KZF-L162R Mutation Affects Splenic Mature B Cell Development and Alters Expression of Aiolos Target Genes

Gregory Lazarian, Shanye Yin, PhD, Alba Font-tello, PhD, Elisa Ten Hacken, PhD, Tomasz Sevastianik, PhD, Daniel Tom, Fara Faye Regis, BS, Amy Gill, Mei Zheng, Katia Georgopoulos, PhD, Donna S Neuberg, ScD, Lili Wang, MDPhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2018) 132 (Supplement 1): 668.

https://doi.org/10.1182/blood-2018-99-115483

Published: 2018

Journal Articles

Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling

Lili Wang, MDPhD, Shanye Yin, PhD, Aina zurita Martinez, Fara Faye Regis, BS, Angela Brooks, PhD, Sarah E. M. Herman, PhD, Elisa Ten Hacken, PhD, Esther Obeng, MD PhD, Dean Campagna, BS, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MDPhD, Adrian Wiestner, MD, Ignaty Leshchiner, PhD, Gad Getz, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD

Blood (2018) 132 (Supplement 1): 947.

https://doi.org/10.1182/blood-2018-99-117691

Published: 2018

Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Blood (2017) 130 (Supplement 1): 264.

https://doi.org/10.1182/blood.V130.Suppl_1.264.264

Published: 2017

Journal Articles

The Clinical BET Inhibitor, GS-5829, Is Active Against Chronic Lymphocytic Leukemia As Single Agent and in Combination with B-Cell Receptor Signaling Inhibitors

Ekaterina Kim, PhD, Elisa Ten Hacken, PhD, Astrid Clarke, PhD, Michael J. Keating, MD, William G Wierda, MD PhD, Alessandra Ferrajoli, MD, Nitin Jain, MD, Philip A Thompson, MBBS, Zeev Estrov, MD, Jan A. Burger, MD PhD

Blood (2017) 130 (Supplement 1): 3844.

https://doi.org/10.1182/blood.V130.Suppl_1.3844.3844

Published: 2017

Journal Articles

Dynamic BH3 Profiling to Assess the Effects of Novel Agents on Anti-Apoptotic Protein Dependence of CLL Cells

Rebecca Valentin, MD, Jing Deng, PhD, Elisa Ten Hacken, PhD, Timothy Z. Lehmberg, BA, Silvia Buonamici, PhD, Donna S. Neuberg, ScD, Catherine J. Wu, MD, Anthony Letai, MD PhD, Matthew S. Davids, MD MMSc

Blood (2017) 130 (Supplement 1): 4289.

https://doi.org/10.1182/blood.V130.Suppl_1.4289.4289

Published: 2017

Journal Articles

Ibrutinib Targets Nurse-like Cells Supporting an Immunosuppressive Phenotype in Chronic Lymphocytic Leukemia

Stefania Fiorcari, PhD, Rossana Maffei, PhD, Valentina Audrito, PhD, Silvia Martinelli, PhD, Elisa Ten Hacken, PhD, Giulia Grisendi, PhD, Patrizia Zucchini, Chiara Quadrelli, PhD, Mario Luppi, MD, PhD, Jan A. Burger, MD, PhD, Silvia Deaglio, Roberto Marasca, MD

Blood (2015) 126 (23): 613.

https://doi.org/10.1182/blood.V126.23.613.613

Published: 2015

Journal Articles

IgM and IgD Receptors Differentially Contribute to CLL Survival and Chemokine Secretion: Implications for CLL Biology and Treatment

Elisa ten Hacken, PhD, Mariela Sivina, PhD, Li Ping, PhD, Susan O'Brien, MD, William G. Wierda, MD PhD, Alessandra Ferrajoli, MD, Zeev Estrov, MD, Michael J. Keating, MD, Cristina Scielzo, Paolo Ghia, MD PhD, Federico Caligaris-Cappio, MD, Jan A. Burger, MD PhD

Blood (2015) 126 (23): 2915.

https://doi.org/10.1182/blood.V126.23.2915.2915

Published: 2015

Journal Articles

Identification of B Cell Receptor Antigens in the Chronic Lymphocytic Leukemia Microenvironment

Elisa ten Hacken, PhD, Thomas Oellerich, MD, Maria Gounari, PhD, Julia Hoellenriegel, MS, Kuan-Ting Pan, PhD, Susan O'Brien, MD, William Wierda, MD PhD, Alessandra Ferrajoli, MD, Zeev Estrov, MD, Michael J. Keating, MD, Henning Urlaub, PhD, Paolo Ghia, MD PhD, Jan A. Burger, MD PhD

Blood (2015) 126 (23): 2922.

https://doi.org/10.1182/blood.V126.23.2922.2922

Published: 2015

Journal Articles

Correlation Between Clinical Responses and Immune Characteristics in Patients with Relapsed CLL Treated with Ofatumumab and Lenalidomide

Candida Vitale, MD, Lorenzo Falchi, MD, Elisa ten Hacken, PhD, Hui Gao, PhD, Hila Shaim, MD, Katrien Van Roosbroeck, PhD, George Calin, MDPhD, Susan O'Brien, MD, Stefan Faderl, MD, Xuemei Wang, MS, William Wierda, MD PhD, Katayoun Rezvani, MDPhD, James M Reuben, PhD, Jan A. Burger, MD PhD, Michael Keating, MBBS, Alessandra Ferrajoli, MD

Blood (2015) 126 (23): 1748.

https://doi.org/10.1182/blood.V126.23.1748.1748

Published: 2015

Journal Articles

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Stefan Koehrer, MD, Ondrej Havranek, MDPhD, R Eric Davis, MD, Felix Seyfried, MD, Greg Coffey, PhD, Ekaterina Kim, MS, Nathalie Y. Rosin, PhD, Elisa ten Hacken, PhD, Ulrich Jäger, MD, Katrina Vanura, PhD, Susan O'Brien, MD, Deborah A. Thomas, MD, Hagop M. Kantarjian, MD, Dipanjan Ghosh, PhD, Zhiqiang Wang, Lüder Hinrich Meyer, MD, Hassan Jumaa, PhD, Jan A. Burger, MDPhD

Blood (2014) 124 (21): 287.

https://doi.org/10.1182/blood.V124.21.287.287

Published: 2014

Journal Articles

Nurse-like Cells Engage Sigm and Sigd on Chronic Lymphocytic Leukemia (CLL) Cells: Implications for BCR Signaling Activation and Functional Outcome

Elisa ten Hacken, PhD, Cristina Scielzo, PhD, Susan O'Brien, MD, William G. Wierda, MD PhD, Michael Keating, MBBS, Paolo Ghia, MD PhD, Federico Caligaris-Cappio, MD, Jan A. Burger, MD PhD

Blood (2014) 124 (21): 3312.

https://doi.org/10.1182/blood.V124.21.3312.3312

Published: 2014

NARROW

RPS15 and TP53 Co-Mutation Drives B Cell Malignancy through Altered Translation and MYC Activation in a Murine Model

IKZF3 Overexpression Phenocopies Gain-of-Function Mutation in Chronic Lymphocytic Leukemia

Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome

Expression of Sf3b1-K700E accelerates the Development of Chronic Lymphocytic Leukemia in a Del (13q) Murine Model

B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL

Interrogation of Individual CLL Loss-of-Function Lesions By CRISPR In Vivo Editing Reveals Common and Unique Pathway Alterations

MCL-1 and PKA/AMPK Axis Fuel Venetoclax Resistance in Lymphoid Cancers

Identification of Genotype-Specific Therapeutic Vulnerabilities By Comparative Dynamic BH3 Profiling Analysis of Human and Murine CLL

KZF-L162R Mutation Affects Splenic Mature B Cell Development and Alters Expression of Aiolos Target Genes

Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

The Clinical BET Inhibitor, GS-5829, Is Active Against Chronic Lymphocytic Leukemia As Single Agent and in Combination with B-Cell Receptor Signaling Inhibitors

Dynamic BH3 Profiling to Assess the Effects of Novel Agents on Anti-Apoptotic Protein Dependence of CLL Cells

Ibrutinib Targets Nurse-like Cells Supporting an Immunosuppressive Phenotype in Chronic Lymphocytic Leukemia

IgM and IgD Receptors Differentially Contribute to CLL Survival and Chemokine Secretion: Implications for CLL Biology and Treatment

Identification of B Cell Receptor Antigens in the Chronic Lymphocytic Leukemia Microenvironment

Correlation Between Clinical Responses and Immune Characteristics in Patients with Relapsed CLL Treated with Ofatumumab and Lenalidomide

Immunoglobulin Heavy Chain (IgH) Knockout Inhibits Proliferation of Pre-BCR + B-Cell Acute Lymphoblastic Leukemia (B-ALL) Via a FOXO1 and MYC Dependent Mechanism

Nurse-like Cells Engage Sigm and Sigd on Chronic Lymphocytic Leukemia (CLL) Cells: Implications for BCR Signaling Activation and Functional Outcome

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American Society of Hematology

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ASH Publications

American Society of Hematology

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