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Journal Articles

Preclinical Safety of Baxter's Recombinant ADAMTS13

Christina Piskernik, DVM, Barbara Dietrich, DVM, Susan Kubik, BSc, Tanja Ruthsatz, DVM, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, DVM

Blood (2012) 120 (21): 3381.

https://doi.org/10.1182/blood.V120.21.3381.3381

Published: 2012

Journal Articles

Preclinical Efficacy Testing of Baxter's Recombinant ADAMTS13 in a Mouse Model of TTP.

Alexandra Schiviz, DVM, Marlene Resch, DVM, Elisa Farnleitner, Hanspeter Rottensteiner, PhD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Werner Hoellriegl, PhD, Eva-Maria Muchitsch, DVM

Blood (2012) 120 (21): 2216.

https://doi.org/10.1182/blood.V120.21.2216.2216

Published: 2012

Journal Articles

Impact of Factor IXa Content On Function, Safety and Efficacy of Recombinant Factor IX Products.

Wilfried Auer, PhD, Hanspeter Rottensteiner, PhD, Gerald Schrenk, PhD, Werner Hoellriegl, PhD, Alexandra Schiviz, DVM, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Peter L Turecek, PhD, Eva-Maria Muchitsch, PhD

Blood (2012) 120 (21): 2233.

https://doi.org/10.1182/blood.V120.21.2233.2233

Published: 2012

Journal Articles

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13

Alexandra Schiviz, Kuno Wuersch, Christina Piskernik, Barbara Dietrich, Werner Hoellriegl, Hanspeter Rottensteiner, Friedrich Scheiflinger, Hans Peter Schwarz, Eva-Maria Muchitsch

Blood (2012) 119 (25): 6128–6135.

https://doi.org/10.1182/blood-2011-09-380535

Published: 2012

Includes: Supplemental data

Journal Articles

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Michael Dockal, PhD, Rudolf Hartmann, PhD, Thomas Polakowski, MBA, Osterkamp Frank, Hartmut J. Ehrlich, MD, Alexandra Schiviz, Werner Hoellriegl, Eva-Maria Muchitsch, Ulrich Reinecke, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 24.

https://doi.org/10.1182/blood.V118.21.24.24

Published: 2011

Journal Articles

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Michael Dockal, PhD, Werner Hoellriegl, Zhenqing Zhang, Susanne Till, PhD, Sabine Knappe, PhD, Michael Palige, PhD, Alexandra Schiviz, Hartmut J. Ehrlich, MD, Christina Szabo, Eva-Maria Muchitsch, Friedrich Scheiflinger, PhD

Blood (2011) 118 (21): 2262.

https://doi.org/10.1182/blood.V118.21.2262.2262

Published: 2011

Journal Articles

Safety of Baxter’s Longer Acting rFVIII (BAX 855) After Repeated Application in Rats and Cynomolgus Monkeys

Barbara Dietrich, DVM, Margit Spatzenegger, PhD, Reinhard Stidl, PhD, Martin Wolfsegger, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4345.

https://doi.org/10.1182/blood.V118.21.4345.4345

Published: 2011

Journal Articles

Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys

Gerald Hoebarth, DVM, Susan Kubik, BSc, Martin Wolfsegger, PhD, John-Philip Lawo, Alfred Weber, PhD, Herbert Gritsch, Werner Hoellriegl, Alexandra Schiviz, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Peter L Turecek, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4346.

https://doi.org/10.1182/blood.V118.21.4346.4346

Published: 2011

Journal Articles

Efficacy of Baxter’s Longer Acting rFVIII (BAX 855) in Mouse Models of Hemophilia A

Alexandra Schiviz, Eder Barbara, John-Philip Lawo, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Peter L Turecek, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, Werner Hoellriegl

Blood (2011) 118 (21): 4350.

https://doi.org/10.1182/blood.V118.21.4350.4350

Published: 2011

Journal Articles

Preclinical Safety Pharmacology of Baxter’s Longer Acting rFVIII (BAX 855)

Barbara Dietrich, DVM, Susan Kubik, BSc, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4357.

https://doi.org/10.1182/blood.V118.21.4357.4357

Published: 2011

Journal Articles

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Reinhard Stidl, PhD, Juergen Siekmann, PhD, Sean M Culbertson, Tony Vinson, Antoni Kozlowski, Xiaoming Shen, Mary J Bossard, Hanspeter Rottensteiner, PhD, Barbara Dietrich, DVM, Chyung Cook, Peter L Turecek, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch

Blood (2011) 118 (21): 4358.

https://doi.org/10.1182/blood.V118.21.4358.4358

Published: 2011

Journal Articles

Toxico-Kinetics of Recombinant VWF In Non-Human Primates and Rabbits

Eva-Maria Muchitsch, PhD, Barbara Dietrich, PhD, Hanspeter Rottensteiner, PhD, Herbert Gritsch, Hartmut J. Ehrlich, MD, Peter Turecek, PhD, Hans Peter Schwarz, MD

Blood (2010) 116 (21): 1414.

https://doi.org/10.1182/blood.V116.21.1414.1414

Published: 2010

Journal Articles

Preclinical Safety of Baxter's Recombinant Factor VIIa

Barbara Dietrich, PhD, Susan Kubik, PhD, Wilfried Auer, PhD, Birgit Reipert, PhD, Frank Horling, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 1417.

https://doi.org/10.1182/blood.V116.21.1417.1417

Published: 2010

Journal Articles

Preclinical Safety of Baxter's Recombinant Factor IX

Barbara Dietrich, PhD, Susan Kubik, PhD, Wilfried Auer, PhD, Kuno Wuersch, PhD, Birgit Reipert, PhD, Frank Horling, PhD, Martin Wolfsegger, PhD, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4654.

https://doi.org/10.1182/blood.V116.21.4654.4654

Published: 2010

Journal Articles

Single Dose Pharmacokinetics of a Recombinant FVIIa In Factor VIII KO Mice, Rats, and Cynomolgus Monkeys

Gerald Hoebarth, PhD, Susan Kubik, PhD, Martin Wolfsegger, PhD, John-Philip Lawo, PhD, Alfred Weber, PhD, Herbert Gritsch, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4655.

https://doi.org/10.1182/blood.V116.21.4655.4655

Published: 2010

Journal Articles

Preclinical Efficacy Testing of Baxter's Recombinant FVIIa

Alexandra Schiviz, PhD, John-Philip Lawo, PhD, Marlene Resch, Peter Leidenmuehler, Bettina Bischetsrieder, Hartmut J. Ehrlich, MD, Friedrich Scheiflinger, PhD, Hans Peter Schwarz, MD, Werner Hoellriegl, PhD, Eva-Maria Muchitsch, PhD

Blood (2010) 116 (21): 4659.

https://doi.org/10.1182/blood.V116.21.4659.4659

Published: 2010

Journal Articles

In Vitro and In Vivo Characterization of Full-Length rFVIII Modified with PEG Via Coupling to Primary Amino Groups.

Peter L. Turecek, PhD, Jürgen Siekmann, PhD, Herbert Gritsch, Katalin Váradi, PhD, Rafi-Uddin Ahmad, Eva-Maria Muchitsch, DVM, Hartmut Ehrlich, MD, Hans Peter Schwarz, MD

Blood (2007) 110 (11): 3147.

https://doi.org/10.1182/blood.V110.11.3147.3147

Published: 2007

Journal Articles

PEGylation or Polysialylation Reduces FVIII Binding to LRP Resulting in Prolonged Half-Life in Murine Models.

Hanspeter Rottensteiner, Peter L. Turecek, PhD, Rona Pendu, Alexander B. Meijer, Peter Lenting, Koen Mertens, PhD, Eva-Maria Muchitsch, DVM, Hartmut Ehrlich, MD, Hans Peter Schwarz, MD

Blood (2007) 110 (11): 3150.

https://doi.org/10.1182/blood.V110.11.3150.3150

Published: 2007

Journal Articles

Species-Dependent Variability of ADAMTS-13 Mediated Proteolysis of Human Recombinant von Willebrand Factor.

Katalin Varadi, PhD, Hanspeter Rottensteiner, PhD, Peter L. Turecek, PhD, Jutta Schreiner, Herbert Gritsch, Bernhard Baumgartner, DVM, Eva-Maria Muchitsch, DVM, Hartmut Ehrlich, MD, Hans Peter Schwarz, MD

Blood (2007) 110 (11): 2139.

https://doi.org/10.1182/blood.V110.11.2139.2139

Published: 2007

Journal Articles

Modification of rVWF with Polysialic Acid: Biochemical and Functional Characterization in Mice with VWD.

Peter L. Turecek, PhD, Juergen Siekmann, PhD, Alfred Weber, PhD, Herbert Gritsch, PhD, Katalin Váradi, PhD, H. Peter Matthiessen, PhD, Eva-Maria Muchitsch, DVM, Bernhard Baumgartner, DVM, Hans Peter Schwarz, MD

Blood (2006) 108 (11): 1001.

https://doi.org/10.1182/blood.V108.11.1001.1001

Published: 2006

NARROW

Preclinical Safety of Baxter's Recombinant ADAMTS13

Preclinical Efficacy Testing of Baxter's Recombinant ADAMTS13 in a Mouse Model of TTP.

Impact of Factor IXa Content On Function, Safety and Efficacy of Recombinant Factor IX Products.

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13

Peptides Inhibiting Tissue Factor Pathway Inhibitor Improve Hemostasis in Mice

Structural and Functional Characterization of Fucoidan and Its Procoagulant Effect in An Ex Vivo Model of Factor VIII-Inhibited Guinea Pigs

Safety of Baxter’s Longer Acting rFVIII (BAX 855) After Repeated Application in Rats and Cynomolgus Monkeys

Pharmacokinetics of Baxter’s Longer Acting rFVIII (BAX 855) in Factor VIII Ko Mice, Rats and Cynomolgus Monkeys

Efficacy of Baxter’s Longer Acting rFVIII (BAX 855) in Mouse Models of Hemophilia A

Preclinical Safety Pharmacology of Baxter’s Longer Acting rFVIII (BAX 855)

Absorption, Metabolism, Distribution, and Excretion of Longer Acting rFVIII (BAX 855) Following Intravenous Administration to Rats

Toxico-Kinetics of Recombinant VWF In Non-Human Primates and Rabbits

Preclinical Safety of Baxter's Recombinant Factor VIIa

Preclinical Safety of Baxter's Recombinant Factor IX

Single Dose Pharmacokinetics of a Recombinant FVIIa In Factor VIII KO Mice, Rats, and Cynomolgus Monkeys

Preclinical Efficacy Testing of Baxter's Recombinant FVIIa

In Vitro and In Vivo Characterization of Full-Length rFVIII Modified with PEG Via Coupling to Primary Amino Groups.

PEGylation or Polysialylation Reduces FVIII Binding to LRP Resulting in Prolonged Half-Life in Murine Models.

Species-Dependent Variability of ADAMTS-13 Mediated Proteolysis of Human Recombinant von Willebrand Factor.

Modification of rVWF with Polysialic Acid: Biochemical and Functional Characterization in Mice with VWD.

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American Society of Hematology

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American Society of Hematology

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