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Giovannino Silvestri, PhD
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Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Giovannino Silvestri, PhD, Rossana Trotta, PhD, Lorenzo Stramucci, PhD, Shuzhen Wang, PhD, Ann-Kathrin Eisfeld, MD, Bin Zhang, PhD, Klara Srutova, PhD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Fabio Stagno, MD, Paolo Vigneri, MD PhD, Georgios Nteliopoulos, PhD, Martin Guimond, PhD, Peter Hokland, MD DMSc, Michael W. Deininger, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, MD, Jane Apperley, MB, ChB, MD, Guido Marcucci, MD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Bruno Calabretta, MD PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4141.
https://doi.org/10.1182/blood-2019-131113
Published: 2019
Journal Articles

The Bone Marrow Niche Uses Mir-300 As a Biological Rheostat to Selectively Control Stem Cell-Driven Malignant Hematopoiesis and Innate Anti-Cancer Immunity

Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Justin Ellis, Jason Harb, PhD, Paolo Neviani, PhD, Bin Zhang, PhD, Klara Srutova, PhD, Carlo Gambacorti-Passerini, MD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Bruno Calabretta, MD PhD, Fabio Stagno, MD PhD, Paolo Vigneri, MD PhD, G. Nteliopoulos, Philippa May, Alistair Reid, BSc, PhD, Ramiro Garzon, MD, Denis-Claude Roy, MD, Martin Guimond, PhD, Peter Hokland, MD, Michael W. Deininger, MD PhD, Garrett Fitzgerald, MD, Chris Harman, MD, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, PhD, Jane F. Apperley, FRCP, FRCPath, MD MBChB, Guido Marcucci, MD, Jianfei Qi, PhD, Kateřina Machová Poláková, PhD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 45.
https://doi.org/10.1182/blood.V130.Suppl_1.45.45
Published: 2017
Journal Articles

Potential Targeting Ph + Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity

Justine Yu, B.S., Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Masashi Sanada, MD PhD, Tomoyuki Yamaguchi, PhD, Yang Du, PhD, Jukka Westermarck, MD PhD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, Dragana Milojkovic, MD, Jane F. Apperley, MD, Denis-Claude Roy, MD, Guido Marcucci, MD, Bruno Calabretta, MD PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2909.
https://doi.org/10.1182/blood.V128.22.2909.2909
Published: 2016
Journal Articles

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML

Giovannino Silvestri, PhD, Lorenzo Stramucci, PhD, Justin Ellis, Justine Yu, Jason Harb, PhD, Paolo Neviani, PhD, Guido Marcucci, MD, Klara Srutova, Katerina Machova Polakova, Denis-Claude Roy, MD, Peter Hokland, MD, Michael W. Deininger, Ravi Bhatia, MD, Carlo Gambacorti-Passerini, Dragana Milojkovic, Alistair G Reid, BSc, PhD, Jane F. Apperley, MD, Ferenc Livak, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2015) 126 (23): 53.
https://doi.org/10.1182/blood.V126.23.53.53
Published: 2015
Journal Articles

MiR-300 Acts As a Tumor Supressor in Ph+ Progenitors By Modulating the JAK2-SET/PP2A/β-Catenin Interplay

Giovannino Silvestri, PhD, Justin Ellis, Lorenzo Stramucci, PhD, Jason G Harb, PhD, Paolo Neviani, PhD, Guido Marcucci, MD, Denis-Claude Roy, MD, Peter Hokland, MD DMSc, Dragana Milojkovic, Alistair Reid, Jane F. Apperley, Ferenc M Livak, PhD, Maria R. Baer, MD, Rossana Trotta, PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4529.
https://doi.org/10.1182/blood.V124.21.4529.4529
Published: 2014