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Journal Articles

Rapid and Robust Mobilization of CD34+ HSCs without G-CSF Following Administration of Mgta-145 Alone or in Combination with Plerixafor

John F. DiPersio, MD PhD, Jonathan Hoggatt, PhD, Steven Devine, MD, Lukasz Biernat, MD, Haley Howell, BS, BA, Veit Schmelmer, PhD, Jason R. Neale, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Kevin A. Goncalves, PhD, Glen D. Raffel, MD PhD, Patrick C. Falahee, PhD, Dwight M. Morrow, PhD, John C. Davis, Jr., MD MPH, MS

Blood (2019) 134 (Supplement_1): 1961.

https://doi.org/10.1182/blood-2019-127523

Published: 2019

Journal Articles

Mgta-456, an Aryl Hydrocarbon Receptor (AHR) Antagonist Based Expansion of CD34+ Hematopoietic Stem Cells (HSC), Permits Selection of Better HLA Matched Cord Blood Units (CBUs) and Promotes Faster Neutrophil Recovery and Uniform Engraftment with Potentially Less Acute Graft-Vs-Host Disease (GVHD)

Heather Stefanski, MD PhD, Claudio G Brunstein, MD PhD, David H. McKenna, MD, Darin Sumstad, MLS, Jeffrey S. Miller, MD, Bruce R. Blazar, MD, Todd E. DeFor, MS, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Glen D. Raffel, MD PhD, John C. Davis, Jr., MD MPH, MS, John E. Wagner, MD

Blood (2019) 134 (Supplement_1): 804.

https://doi.org/10.1182/blood-2019-122329

Published: 2019

Journal Articles

Preliminary Phase 2 Results Demonstrate Engraftment with Minimal Neutropenia with MGTA-456, a CD34 + Expanded Cord Blood (CB) Product in Patients Transplanted for Inherited Metabolic Disorders (IMD)

Paul Orchard, MD, Glen D. Raffel, MD, Carolyn H Condon, MPH, Catherine A Monaghan, Demetra Vernet, Suzanne Tracey Sheirr, Jennifer Braun, RN BSN, Ryan Shanley, M.S, Troy C Lund, MD MS, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, John C Davis, MD MPH, John E. Wagner, MD

Blood (2018) 132 (Supplement 1): 3467.

https://doi.org/10.1182/blood-2018-99-115102

Published: 2018

Journal Articles

High Dose Mitoxantrone Based "5+1" Induction Chemotherapy Regimen in Newly Diagnosed Acute Myeloid Leukemia

Neeraj Y Saini, MD, Jan Cerny, MD PhD, Vanessa Furtado, MD, Angela Desmond, Zheng Zhou, Glen D. Raffel, MD, Imran Puthawala, Jayde Bednarik, PharmD, Lindsey Shanahan, Patricia Minehart Miron, PhD, Bruce Woda, MD, Muthalagu Ramanathan, MD, Rajneesh Nath, MD

Blood (2018) 132 (Supplement 1): 1430.

https://doi.org/10.1182/blood-2018-99-116857

Published: 2018

Journal Articles

Targeting the Mechanism of c-Mpl Exon-Inclusion through Antisense Oligonucleotides Yields a Dominant Negative Isoform

Sakiko Suzuki, MD, Ronny R Racine, PhD BS, Nathan A Manalo, MS, Neeraj Saini, MD, Cliff Odour, Michael Moazami, MS, Jeffrey A Bailey, MD PhD, Jonathan K Watts, PhD, Glen D. Raffel, MD PhD

Blood (2017) 130 (Supplement 1): 383.

https://doi.org/10.1182/blood.V130.Suppl_1.383.383

Published: 2017

Journal Articles

Outcomes of Allogeneic Stem Cell Transplant (Allo-SCT) for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) in Patients Older Than 75 Years: A Single Center Analysis

Rajneesh Nath, MD, Jan Cerny, MD PhD, Muthalagu Ramanathan, MD, Zheng Zhou, MD PhD, Neng Yu, MD, Glen D Raffel, MD PhD, Jayde Bednarik, PharmD

Blood (2016) 128 (22): 5875.

https://doi.org/10.1182/blood.V128.22.5875.5875

Published: 2016

Journal Articles

Ott1(Rbm15) Regulates p53 Levels during Oncogenic and Proliferative Stress

Sakiko Suzuki, MD, Nathan A Manalo, B.A. M.A., Glen D Raffel, MD PhD

Blood (2015) 126 (23): 1189.

https://doi.org/10.1182/blood.V126.23.1189.1189

Published: 2015

Journal Articles

Unrelated Donor (UD) Cord Blood (CB) Stem Cell Transplantation (SCT) from a Single CB Unit in Older Adults: Excellent Engraftment and Low Early Mortality with a Preparative Regimen of Melphalan (M), Thiotepa (T), Fludarabine(F), and Rabbit (r) Anti Thymocyte Globulin (ATG)

Rajneesh Nath, MD, Muthalagu Ramanathan, MD, Jan Cerny, MD PhD, Zheng Zhou, MD PhD, Glen D Raffel, MD PhD, Jayde Bednarik, Pharm D, Neng Yu, MD, Laura J Petrillo-Deluca, PA-C, Zeina Al-Mansour, MD, Zankar Desai

Blood (2014) 124 (21): 1152.

https://doi.org/10.1182/blood.V124.21.1152.1152

Published: 2014

Journal Articles

Ott1 (Rbm15) Is Required for the Large to Small Pre B-Cell Transition

Michael Kharas, John Manis, MD, D. Gary Gilliland, MD, PhD, Glen D. Raffel, MD, PhD

Blood (2008) 112 (11): 706.

https://doi.org/10.1182/blood.V112.11.706.706

Published: 2008

Journal Articles

Vascular Branching Morphogenesis of the Placenta Requires Expression of Ott1(Rbm15) in the Trophoblast Compartment.

Glen D. Raffel, MD, PhD, Gerry C Chu, Dana E. Cullen, Roderick T Bronson, DVM, Olivier A Bernard, D. Gary Gilliland

Blood (2008) 112 (11): 1895.

https://doi.org/10.1182/blood.V112.11.1895.1895

Published: 2008

Journal Articles

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Thomas Mercher, Ph.D, Glen D. Raffel, MD, PhD, Sandra A Moore, Melanie G Cornejo, Dominique Baudry-Bluteau, Ph.D, Nicolas Cagnard, Jonathan Jesneck, Yana Pikman, Dana E. Cullen, Ifor Williams, Koichi Akashi, MD, PhD, Hirokazu Shigematsu, Jean-Pierre Bourquin, MD, PhD, Marco Giovannini, MD, PhD, William Vainchenker, Ross L Levine, MD, Benjamin H. Lee, MD, PhD, Olivier Bernard, D. Gary Gilliland

Blood (2008) 112 (11): 508.

https://doi.org/10.1182/blood.V112.11.508.508

Published: 2008

Journal Articles

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

Glen D. Raffel, MD, PhD, Thomas Mercher, Ph.D., Hirokazu Shigematsu, M.D., Ifor R. Williams, M.D., Ph.D., Dana E. Cullen, Koichi Akashi, M.D., Ph.D., Olivier A. Bernard, Ph.D., D. Gary Gilliland, M.D., Ph.D.

Blood (2006) 108 (11): 784.

https://doi.org/10.1182/blood.V108.11.784.784

Published: 2006

NARROW

Rapid and Robust Mobilization of CD34+ HSCs without G-CSF Following Administration of Mgta-145 Alone or in Combination with Plerixafor

Mgta-456, an Aryl Hydrocarbon Receptor (AHR) Antagonist Based Expansion of CD34+ Hematopoietic Stem Cells (HSC), Permits Selection of Better HLA Matched Cord Blood Units (CBUs) and Promotes Faster Neutrophil Recovery and Uniform Engraftment with Potentially Less Acute Graft-Vs-Host Disease (GVHD)

Preliminary Phase 2 Results Demonstrate Engraftment with Minimal Neutropenia with MGTA-456, a CD34 + Expanded Cord Blood (CB) Product in Patients Transplanted for Inherited Metabolic Disorders (IMD)

High Dose Mitoxantrone Based "5+1" Induction Chemotherapy Regimen in Newly Diagnosed Acute Myeloid Leukemia

Targeting the Mechanism of c-Mpl Exon-Inclusion through Antisense Oligonucleotides Yields a Dominant Negative Isoform

Outcomes of Allogeneic Stem Cell Transplant (Allo-SCT) for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) in Patients Older Than 75 Years: A Single Center Analysis

Ott1(Rbm15) Regulates p53 Levels during Oncogenic and Proliferative Stress

Unrelated Donor (UD) Cord Blood (CB) Stem Cell Transplantation (SCT) from a Single CB Unit in Older Adults: Excellent Engraftment and Low Early Mortality with a Preparative Regimen of Melphalan (M), Thiotepa (T), Fludarabine(F), and Rabbit (r) Anti Thymocyte Globulin (ATG)

Ott1 (Rbm15) Is Required for the Large to Small Pre B-Cell Transition

Vascular Branching Morphogenesis of the Placenta Requires Expression of Ott1(Rbm15) in the Trophoblast Compartment.

OTT-MAL Activates the Notch Signaling Transcription Factor RBPJ and Cooperates with Mutant MPL to Induce Acute Megakaryoblastic Leukemia

Ott1(Rbm15) Is Essential for Pre-B Differentiation and Has an Inhibitory Role in Myeloid and Megakaryocytic Lineages.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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