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Journal Articles

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Blood (2019) 134 (Supplement_1): 744.

https://doi.org/10.1182/blood-2019-129411

Published: 2019

Journal Articles

Phase I Experience with a Bi-Specific CAR Targeting CD19 and CD22 in Adults with B-Cell Malignancies

Nasheed Hossain, MD, Bita Sahaf, PhD, Matthew Abramian, PhD, Jay Y. Spiegel, MD, Katie Kong, Stephen Kim, Sharon Mavroukakis, Jean Oak, MD PhD, Yasodha Natkunam, MD PhD, Everett H Meyer, MD PhD, Matthew J. Frank, MD PhD, Steven A Feldman, PhD, Steven R. Long, MD, Haiying Qin, MS, Terry J. Fry, MD, Lori S Muffly, MD, Crystal L. Mackall, MD, David B. Miklos, MD PhD

Blood (2018) 132 (Supplement 1): 490.

https://doi.org/10.1182/blood-2018-99-110142

Published: 2018

Journal Articles

Phase 1 Study of CD19/CD22 Bispecific Chimeric Antigen Receptor (CAR) Therapy in Children and Young Adults with B Cell Acute Lymphoblastic Leukemia (ALL)

Liora M Schultz, MD, Kara L. Davis, DO, Christina Baggott, RN, PhD, Christie Chaudry, NP, Anne Cunniffe Marcy, MSBH, Sharon Mavroukakis, Bita Sahaf, PhD, Katherine A Kong, Lori S Muffly, MD, Stephen Kim, Everett H Meyer, MD PhD, Terry J. Fry, MD, Haiying Qin, MS, David B. Miklos, MD PhD, Crystal L. Mackall, MD

Blood (2018) 132 (Supplement 1): 898.

https://doi.org/10.1182/blood-2018-99-117445

Published: 2018

Journal Articles

Direct Comparison of Anti-CD33 and Anti-CD123 Chimeric Antigen Receptor T Cells with CD28 or 41BB Co-Stimulatory Domains for Treatment of Acute Myeloid Leukemia

Samiksha Tarun, MSc, Haiying Qin, MS, Lila Yang, BS, Christopher Daniel Chien, PhD, Mark Eric Kohler, MD PhD, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 1370.

https://doi.org/10.1182/blood.V130.Suppl_1.1370.1370

Published: 2017

Journal Articles

Novel CD19/CD22 Bicistronic Chimeric Antigen Receptors Outperform Single or Bivalent Cars in Eradicating CD19 + CD22 + , CD19 - , and CD22 - Pre-B Leukemia

Haiying Qin, MS, Sang M Nguyen, BS, Sneha Ramakrishna, MD, Samiksha Tarun, MSc, Lila Yang, BS, Nicholas Peter Verdini, BS, Waleed Haso, MS, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 810.

https://doi.org/10.1182/blood.V130.Suppl_1.810.810

Published: 2017

Journal Articles

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

Sneha Ramakrishna, MD, Sang M Nguyen, BS, Haiying Qin, MS, Steven L Highfill, PhD, Ira Kraft, John Shern, MD, Zachary Walsh, Dimiter Dimitrov, PhD, Terry J Fry, MD

Blood (2017) 130 (Supplement 1): 3894.

https://doi.org/10.1182/blood.V130.Suppl_1.3894.3894

Published: 2017

Journal Articles

Preclinical Development of a T-Cell ALL CAR Demonstrates That Differences in CAR Membrane Distribution May Impact Efficacy

Haneen Shalabi, DO, Haiying Qin, MS, Kelsey Wanhainen, BS, Jillian Smith, BS, Rimas Orentas, PhD, Nirali N Shah, MD, Shannon L Maude, MD PhD, Sarah K Tasian, MD, David T Teachey, MD, Javed Khan, MD, Terry J Fry, MD

Blood (2016) 128 (22): 4019.

https://doi.org/10.1182/blood.V128.22.4019.4019

Published: 2016

Journal Articles

Lineage Switch As a Relapse Mechanism of Pre-B Acute Lymphoblastic Leukemia Following CD19 CAR

Elad Jacoby, MD, Sang Minh Nguyen, BS, Kathryn M Welp, Haiying Qin, MS, Yinmeng Yang, BS, Christopher Daniel Chien, PhD, John Shern, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 2524.

https://doi.org/10.1182/blood.V126.23.2524.2524

Published: 2015

Journal Articles

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Yinmeng Yang, BS, Tasha Lin, MD, Elad Jacoby, MD, Haiying Qin, MS, Elizabeth Grier Gardner, MD, Christopher Daniel Chien, PhD, Daniel W. Lee, III, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 100.

https://doi.org/10.1182/blood.V126.23.100.100

Published: 2015

Journal Articles

CRLF2 /Tslpr Overexpressing Acute Lymphoblastic Leukemia Relapse Is Driven By Chemotherapy-Induced TSLP from Bone Marrow Stromal Cells

Christopher Daniel Chien, PhD, Sang Minh Nguyen, BS, Haiying Qin, MS, Elad Jacoby, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 1432.

https://doi.org/10.1182/blood.V126.23.1432.1432

Published: 2015

Journal Articles

Preclinical Development of Bispecific Chimeric Antigen Receptor Targeting Both CD19 and CD22

Haiying Qin, MS, Waleed Haso, MS, Sang Minh Nguyen, BS, Terry J Fry, MD

Blood (2015) 126 (23): 4427.

https://doi.org/10.1182/blood.V126.23.4427.4427

Published: 2015

Journal Articles

Presence of Endogenous TCR Antigen in Vivo Attenuates Efficacy of Anti-CD19 Targeted CAR T Cell Therapy

Yinmeng Yang, BS, Christopher Daniel Chien, PhD, Elad Jacoby, MD, Haiying Qin, MS, Waleed Haso, MS, Terry J Fry, MD

Blood (2014) 124 (21): 3721.

https://doi.org/10.1182/blood.V124.21.3721.3721

Published: 2014

Journal Articles

CD19 CAR T Cells Maintain Efficacy in the Allogeneic Environment but Mediate Acute Graft-Versus-Host-Disease Only in the Presence CD19+ Acute Lymphoblastic Leukemia

Elad Jacoby, MD, Haiying Qin, MS, Yinmeng Yang, BS, Christopher Daniel Chien, PhD, Terry J Fry, MD

Blood (2014) 124 (21): 1115.

https://doi.org/10.1182/blood.V124.21.1115.1115

Published: 2014

Journal Articles

CD22-Targeted Chimeric Antigen Receptor (CAR) T Cells Containing The 4-1BB Costimulatory Domain Demonstrate Enhanced Persistence and Superior Efficacy Against B-Cell Precursor Acute Lymphoblastic Leukemia (ALL) Compared To Those Containing CD28

Waleed Haso, M.S, Haiying Qin, MS, Ling Zhang, Rimas J Orentas, PhD, Terry J Fry, MD

Blood (2013) 122 (21): 1431.

https://doi.org/10.1182/blood.V122.21.1431.1431

Published: 2013

Journal Articles

The T Cell Receptor As An Oncogene: Thymic Expression Of Self-Reactive T Cell Receptors Targeting Survivin Induces T-Cell Lymphoblastic Leukmia

Yongzhi Cui, MD, PhD., Masahiro Onozawa, MD, PhD., Leigh Samsel, MS, Haven Garber, M.D., Hua Zhang, Haiying Qin, MS, Terry J Fry, MD, J. Philip McCoy, PhD, Xiaolin Wu, Ph.D., Peter D Aplan, MD, Crystal L Mackall, MD

Blood (2013) 122 (21): 167.

https://doi.org/10.1182/blood.V122.21.167.167

Published: 2013

Journal Articles

Thymic Stromal Lymphopoeitin Signaling Contributes To Increased Risk Of Relapse Of Pediatric Acute Lympoblastic Leukemia Through Enhanced Survival Of Leukemic Cells That Overexpress Thymic Stromal Lymphopoeitin Receptor

Christopher D Chien, PhD, Matthew Kreitman, Haiying Qin, MS, Terry J Fry, MD

Blood (2013) 122 (21): 2543.

https://doi.org/10.1182/blood.V122.21.2543.2543

Published: 2013

Journal Articles

Tissue Distribution of a Minor Antigen, but Not PD-1 Expression, Predicts the Antileukemia Efficacy of Adoptively Transferred, Antigen-Specific T-Cells in a Preclinical Model of Allogeneic Transplant

Jessica C. Shand, MD, Christian M. Capitini, MD, Haiying Qin, MS, Nicole Nasholm, BS, Terry J. Fry, MD

Blood (2012) 120 (21): 456.

https://doi.org/10.1182/blood.V120.21.456.456

Published: 2012

Journal Articles

Precursor B Cell Acute Lymphoblastic Leukemia Induces Pro-Leukemic Changes in the Bone Marrow Microenvironment That Contribute to Therapeutic Resistance

Christopher D Chien, PhD, Elizabeth D Hicks, Paul P Su, Haiying Qin, MS, Terry J Fry, MD

Blood (2012) 120 (21): 1466.

https://doi.org/10.1182/blood.V120.21.1466.1466

Published: 2012

NARROW

Phase I Trial Using CD19/CD22 Bispecific CAR T Cells in Pediatric and Adult Acute Lymphoblastic Leukemia (ALL)

Phase I Experience with a Bi-Specific CAR Targeting CD19 and CD22 in Adults with B-Cell Malignancies

Phase 1 Study of CD19/CD22 Bispecific Chimeric Antigen Receptor (CAR) Therapy in Children and Young Adults with B Cell Acute Lymphoblastic Leukemia (ALL)

Direct Comparison of Anti-CD33 and Anti-CD123 Chimeric Antigen Receptor T Cells with CD28 or 41BB Co-Stimulatory Domains for Treatment of Acute Myeloid Leukemia

Novel CD19/CD22 Bicistronic Chimeric Antigen Receptors Outperform Single or Bivalent Cars in Eradicating CD19 + CD22 + , CD19 - , and CD22 - Pre-B Leukemia

Modulation of CD22 Antigen Density Improves Efficacy of CD22 Chimeric Antigen Receptor (CAR) T Cells Against CD22 lo B-Lineage Leukemia and Lymphoma

Preclinical Development of a T-Cell ALL CAR Demonstrates That Differences in CAR Membrane Distribution May Impact Efficacy

Lineage Switch As a Relapse Mechanism of Pre-B Acute Lymphoblastic Leukemia Following CD19 CAR

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

CRLF2 /Tslpr Overexpressing Acute Lymphoblastic Leukemia Relapse Is Driven By Chemotherapy-Induced TSLP from Bone Marrow Stromal Cells

Preclinical Development of Bispecific Chimeric Antigen Receptor Targeting Both CD19 and CD22

Presence of Endogenous TCR Antigen in Vivo Attenuates Efficacy of Anti-CD19 Targeted CAR T Cell Therapy

CD19 CAR T Cells Maintain Efficacy in the Allogeneic Environment but Mediate Acute Graft-Versus-Host-Disease Only in the Presence CD19+ Acute Lymphoblastic Leukemia

CD22-Targeted Chimeric Antigen Receptor (CAR) T Cells Containing The 4-1BB Costimulatory Domain Demonstrate Enhanced Persistence and Superior Efficacy Against B-Cell Precursor Acute Lymphoblastic Leukemia (ALL) Compared To Those Containing CD28

The T Cell Receptor As An Oncogene: Thymic Expression Of Self-Reactive T Cell Receptors Targeting Survivin Induces T-Cell Lymphoblastic Leukmia

Thymic Stromal Lymphopoeitin Signaling Contributes To Increased Risk Of Relapse Of Pediatric Acute Lympoblastic Leukemia Through Enhanced Survival Of Leukemic Cells That Overexpress Thymic Stromal Lymphopoeitin Receptor

Tissue Distribution of a Minor Antigen, but Not PD-1 Expression, Predicts the Antileukemia Efficacy of Adoptively Transferred, Antigen-Specific T-Cells in a Preclinical Model of Allogeneic Transplant

Precursor B Cell Acute Lymphoblastic Leukemia Induces Pro-Leukemic Changes in the Bone Marrow Microenvironment That Contribute to Therapeutic Resistance

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American Society of Hematology

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American Society of Hematology

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