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Hakim Echchannaoui
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Journal Articles

Menin-inhibition boosts CAR-T cell therapy against NPM1 mutated and KMT2A-rearranged acute myeloid leukemia

Free
Johanna Rausch, Philipp Wendel, Viktor Fetsch, Marie Kuhmann, Lilian Viehböck, Fenja Gierschek, Najla Abassi, Margarita Dzama, Nadezda Dolgikh, Lea Knapp, Jan Habermann, Catharina Lahrmann, Ann-Katrin Gebel, Matthias Klein, Michael Delacher, Catherine Wölfel, Hakim Echchannaoui, Matthias Theobald, Daniel Sasca, Federico Marini, Robert Zeiser, Evelyn Ullrich, Michael Kühn
Journal: Blood
Blood (2025) 146 (Supplement 1): 866.
https://doi.org/10.1182/blood-2025-866
Published: 2025
Journal Articles

Deep Cellular and Molecular Characterization Reveal a Distinct Phenotype and Metabolic Signature of Human Senescent CD8 + T Cells: Implication for Cancer Cellular Therapy

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Kevin Jan Jan Legscha, Lea Philine Märker, Najla Abassi, Abdul Yilmaz, Catherine Woelfel, Edite Antunes Ferreira, Annekathrin Nedwed, Sara Salome Helbich, Michael Delacher, Federico Marini, Stefan Porubsky, Matthias Theobald, Hakim Echchannaoui
Journal: Blood
Blood (2024) 144 (Supplement 1): 2536.
https://doi.org/10.1182/blood-2024-194719
Published: 2024
Journal Articles

Dual Inhibition of Histone and DNA Methylation in AML Enhances the Effectiveness of TCR-Based Cellular Therapy through Upregulation of Surface MHC Class I/p53 Antigen Complex

Free
Ulrike Regina Schmits, Edite Antunes Ferreira, Borhane Guezguez, David Gomez-Zepeda, Stefan Tenzer, Kevin Jan Legscha, Matthias Theobald, Hakim Echchannaoui
Journal: Blood
Blood (2024) 144 (Supplement 1): 3444.
https://doi.org/10.1182/blood-2024-201347
Published: 2024
Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Free
Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn
Journal: Blood
Blood (2022) 140 (Supplement 1): 6226–6227.
https://doi.org/10.1182/blood-2022-167566
Published: 2022
Journal Articles

p53 Isoform D133p53a: A Novel Transcriptional Enhancer of T-Cell Effector Function to Improve T-Cell Based Cancer Immunotherapy

Free
Kevin Jan Legscha, MDcal Student, Edite Antunes, Research Assistant, Borhane Guezguez, BSc, MSc, PhD, Matthias Theobald, Hakim Echchannaoui, BSc, MSc, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3489.
https://doi.org/10.1182/blood-2018-99-116208
Published: 2018
Journal Articles

Interfering with Arginine Metabolism As a New Treatment Strategy for Multiple Myeloma

Free
Bjoern Jacobi, MD, Lea Stroeher, MS, Nadine Leuchtner, Hakim Echchannaoui, PhD, Alexander Desuki, MD, Lara Kuerzer, Alice Habermeier, Edite Antunes, Eva Amann, John Bomalaski, MD, Closs Ellen, PhD Prof., Matthias Theobald, MD PhD, Markus Munder, MD
Journal: Blood
Blood (2015) 126 (23): 3005.
https://doi.org/10.1182/blood.V126.23.3005.3005
Published: 2015
Journal Articles

Gene Therapy With a High-Affinity Single-Chain p53-Specific TCR Mediates Potent Anti-Tumor Response Without Inducing Gvhd In Vivo

Free
Hakim Echchannaoui, PhD, Jutta Petschenka, PhD student, Edite Antunes, Matthias Theobald, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1657.
https://doi.org/10.1182/blood.V122.21.1657.1657
Published: 2013
Journal Articles

Safe and Effective Adoptive T-Cell Receptor Transfer with a High Affinity Single Chain p53(264–272)-Specific TCR

Free
Hakim Echchannaoui, PhD, Jutta Petschenka, PhD student, Edite Antunes, Matthias Theobald, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4226.
https://doi.org/10.1182/blood.V120.21.4226.4226
Published: 2012