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Journal Articles

Gamma Delta T Cells for Acute Myeloid Leukemia

Fiorela Natali Hernandez Tejada, Jawairia Jawed, Simon Olivares, Kris Michael Mahadeo, Harjeet Singh

Blood (2022) 140 (Supplement 1): 12696.

https://doi.org/10.1182/blood-2022-162635

Published: 2022

Journal Articles

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Lenka V Hurton, PhD, Tiejuan Mi, Kirsten C Switzer, PhD, Ling Zhang, Cuiping Dai, Misun Kim, Karishma R Bavisi, Matthew J Figliola, Vazquez M Lydia, Sourindra N Maiti, Shihuang Su, Drew C Deniger, PhD, Simon Olivares, Laurence J N Cooper, MD PhD, Harjeet Singh, MSc, PhD

Blood (2019) 134 (Supplement_1): 3218.

https://doi.org/10.1182/blood-2019-131419

Published: 2019

Journal Articles

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Blood (2017) 130 (Supplement 1): 2059.

https://doi.org/10.1182/blood.V130.Suppl_1.2059.2059

Published: 2017

Journal Articles

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Partow Kebriaei, MD, Helen Huls, Susan Lynn Neel, RN, OCN, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, MD, Maro Ohanian, DO, Katy Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD

Blood (2017) 130 (Supplement 1): 2060.

https://doi.org/10.1182/blood.V130.Suppl_1.2060.2060

Published: 2017

Journal Articles

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Lenka V. Hurton, PhD, Harjeet Singh, PhD, Kirsten C. Switzer, PhD, Tiejuan Mi, MS, Leo G. Flores, Aaron Orozco, Sourindra N. Maiti, PhD, Shihuang Su, MS, Amer Najjar, PhD, Mary Helen Huls, BS, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 2807.

https://doi.org/10.1182/blood.V128.22.2807.2807

Published: 2016

Journal Articles

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Krina Patel, MD, Simon Olivares, BS, Harjeet Singh, PhD, Lenka V. Hurton, PhD, Mary Helen Huls, BS, Muzaffar H. Qazilbash, MD, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD

Blood (2016) 128 (22): 3366.

https://doi.org/10.1182/blood.V128.22.3366.3366

Published: 2016

Journal Articles

Pre-Emptive Donor Lymphocyte Infusion with CD19-Directed, CAR-Modified T Cells Infused after Allogeneic Hematopoietic Cell Transplantation for Patients with Advanced CD19 + Malignancies

Blood (2015) 126 (23): 862.

https://doi.org/10.1182/blood.V126.23.862.862

Published: 2015

Journal Articles

Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Blood (2014) 124 (21): 311.

https://doi.org/10.1182/blood.V124.21.311.311

Published: 2014

Journal Articles

Functional and Molecular Characterization of Serial Killer CAR+ T Cells Demonstrates Adaptive Modification of Fate and Behavior Based on Tumor Cell Density

Navin Varadarajan, PhD, Laurence JN Cooper, MD PhD, Liadi Ivan, Harjeet Singh, PhD, Badrinath Roysam, Romain Gabrielle, Merouane Amin

Blood (2014) 124 (21): 658.

https://doi.org/10.1182/blood.V124.21.658.658

Published: 2014

Journal Articles

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Janani Krishnamurthy, Brian Rabinovich, Simon Olivares, BS, Mi Teijuan, Kirsten Switzer, Joshua Plummer, Sourindra Maiti, PHD, Harjeet Singh, PhD, Helen Huls, BS, Feng-wang Johanning, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4206.

https://doi.org/10.1182/blood.V122.21.4206.4206

Published: 2013

Journal Articles

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Rineka N Jackson, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4208.

https://doi.org/10.1182/blood.V122.21.4208.4208

Published: 2013

Journal Articles

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R. Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Rineka N. Jackson, BBA, Tingting Liu, BS, Doyle Bosque, ADN, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Chitra M. Hosing, MD, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Laurence J N. Cooper, MD, PhD

Blood (2013) 122 (21): 166.

https://doi.org/10.1182/blood.V122.21.166.166

Published: 2013

Journal Articles

Targeting Leukemias by CD123 Specific Chimeric Antigen Receptor

Radhika Thokala, MS, Harjeet Singh, PhD, Simon Olivares, BS, Richard Champlin, MD, Laurence J N Cooper, MD, PhD

Blood (2011) 118 (21): 1908.

https://doi.org/10.1182/blood.V118.21.1908.1908

Published: 2011

Journal Articles

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

Harjeet Singh, PhD, Hillary N Gibbons, BS, Simon Olivares, BS, Matthew J. Figliola, BS, Margaret J. Dawson, BS, Mary Helen Huls, BS, Dean A Lee, MD, Ph.D, Partow Kebriaei, MD, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD

Blood (2009) 114 (22): 4097.

https://doi.org/10.1182/blood.V114.22.4097.4097

Published: 2009

Journal Articles

IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells.

Lenka V. Hurton, MS, Harjeet Singh, PhD, Simon Olivares, BS, Sonny O. Ang, PhD, Susan Staba Kelly, MD, Partow Kebriaei, MD, Dean A. Lee, MD, PhD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD

Blood (2009) 114 (22): 3035.

https://doi.org/10.1182/blood.V114.22.3035.3035

Published: 2009

Journal Articles

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

Cecele J Denman, MS, Lisa M. Kopp, DO, Vladimir Senyukov, PhD, Sarah Hagemeister, Jennifer Johnson, Maria A Lima Da Silva, Harjeet Singh, PhD, Lenka Hurton, Simon Olivares, BS, Mary Helen Huls, BS, Richard E Champlin, MD, Laurence J.N. Cooper, MD, PhD, Dean A. Lee, MD, PhD

Blood (2009) 114 (22): 3030.

https://doi.org/10.1182/blood.V114.22.3030.3030

Published: 2009

Journal Articles

T Cells Demonstrate Enhanced Specificity for CD19 + Malignancies When Stimulated with IL-21.

Harjeet Singh, MS, PhD, Mary Helen Huls, BS, Margaret J. Dawson, BS, Tiejuan Mi, MS, Gianpietro Dotti, MD, Dean A. Lee, MD, PhD, Partow Kebriaei, MD, Elizabeth J. Shpall, MD, Perry B. Hackett, PhD, Carl H. June, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD, PhD

Blood (2008) 112 (11): 1539.

https://doi.org/10.1182/blood.V112.11.1539.1539

Published: 2008

Journal Articles

CD19-Specific T Cells for Treatment of Pediatric Acute Lymphocytic Leukemia Using Sleeping Beauty Transposition.

Harjeet Singh, PhD, Pallavi R. Manuri, Ph.D., Simon Olivares, B.S., Navid Dara, B.S., Margaret J. Dawson, B.S., Helen Huls, B.S., Dean A. Lee, M.D., Ph.D., Perry B. Hackett, Ph.D., Donald B. Kohn, M.D., Partow Kebriaei, M.D., Elizabeth J. Shpall, M.D., Richard Champlin, M.D., Laurence Cooper, M.D., Ph.D.

Blood (2007) 110 (11): 2820.

https://doi.org/10.1182/blood.V110.11.2820.2820

Published: 2007

Journal Articles

Identifying NK-Cell Donors for Cell Therapy Based on Functional Phenotype.

Lenka Hurton, MS, R. Iram Siddik, B.S., Harjeet Singh, Ph.D., Simon Olivares, M.S, Brian Rabinovich, Ph.D., William Hildebrand, Ph.D., Dean Lee, M.D., Ph.D., Richard Champlin, M.D., Elizabeth Shpall, M.D., Marcelo Fernandez-Vina, Ph.D., Laurence Cooper, M.D., Ph.D.

Blood (2007) 110 (11): 3271.

https://doi.org/10.1182/blood.V110.11.3271.3271

Published: 2007

Journal Articles

Efficacy of ‘Off-the-Shelf’, Commercially-Available, Third-Party Mesenchymal Stem Cells (MSC) in Ex Vivo Cord Blood (CB) Co-Culture Expansion.

Simon N. Robinson, PhD, Paul J. Simmons, Ph.D., Nathalie Brouard, Ph.D., Shannon Kidd, BS, Hong Yang, MD,Ph.D, William K. Decker, Ph.D., Dongxia Xing, Ph.D., David Steiner, Ph.D., Jingjing Ng, MS, Michael Thomas, MS, Richard E. Champlin, MD, Marcos de Lima, MD, Chitra M. Hosing, MD, Laurence Cooper, MD,Ph.D., Harjeet Singh, Ph.D., Patrick A. Zweidler-McKay, MD,Ph.D., Elizabeth J. Shpall, MD

Blood (2007) 110 (11): 4106.

https://doi.org/10.1182/blood.V110.11.4106.4106

Published: 2007

NARROW

Gamma Delta T Cells for Acute Myeloid Leukemia

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Combination Immunotherapy with NY-ESO-1-Specific CAR + T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect

Pre-Emptive Donor Lymphocyte Infusion with CD19-Directed, CAR-Modified T Cells Infused after Allogeneic Hematopoietic Cell Transplantation for Patients with Advanced CD19 + Malignancies

Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Functional and Molecular Characterization of Serial Killer CAR+ T Cells Demonstrates Adaptive Modification of Fate and Behavior Based on Tumor Cell Density

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Targeting Leukemias by CD123 Specific Chimeric Antigen Receptor

Third Generation Chimeric Antigen Receptors Containing CD137 or CD134 Signaling Endodomains Augment CD19-Specific T-Cell Effector Function.

IL-7 as a Membrane-Bound Molecule for the Costimulation of Tumor-Specific T Cells.

Sustained Ex Vivo Expansion of Human Peripheral Blood NK Cells Using Artificial APCs Bearing Membrane-Bound IL-21.

T Cells Demonstrate Enhanced Specificity for CD19 + Malignancies When Stimulated with IL-21.

CD19-Specific T Cells for Treatment of Pediatric Acute Lymphocytic Leukemia Using Sleeping Beauty Transposition.

Identifying NK-Cell Donors for Cell Therapy Based on Functional Phenotype.

Efficacy of ‘Off-the-Shelf’, Commercially-Available, Third-Party Mesenchymal Stem Cells (MSC) in Ex Vivo Cord Blood (CB) Co-Culture Expansion.

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American Society of Hematology

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American Society of Hematology

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