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Heike Keilhack
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Journal Articles

Phase 1 Study of Tazemetostat (EPZ-6438), an Inhibitor of Enhancer of Zeste-Homolog 2 (EZH2): Preliminary Safety and Activity in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) Patients

Vincent Ribrag, Jean-Charles Soria, Professor, Jean-Marie Michot, Anna Schmitt, MD, Sophie Postel-Vinay, MD, Fontanet Bijou, MD, Blythe Thomson, MD, Heike Keilhack, PhD, Stephen J. Blakemore, PhD, Larisa Reyderman, PhD, Pavan Kumar, PhD, Greg Fine, MS, Alice McDonald, Peter T Ho, PhD MD, Antoine Italiano, MD
Journal: Blood
Blood (2015) 126 (23): 473.
https://doi.org/10.1182/blood.V126.23.473.473
Published: 2015
Journal Articles

BAP1 Loss Results in EZH2-Dependent Transformation in Myelodysplastic Syndromes

Lindsay M LaFave, PhD, Wendy Béguelin, PhD, Richard Koche, PhD, Matt Teater, Efthymia Papalexi, Barbara Spitzer, MD, Sarah Knutson, PhD, John Campbell, PhD, Heike Keilhack, PhD, Paul M Thomas, PhD, Neil L Kelleher, PhD, Omar Abdel-Wahab, Ari M. Melnick, MD, Scott A. Armstrong, MD PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 713.
https://doi.org/10.1182/blood.V126.23.713.713
Published: 2015
Journal Articles

EZH2 Inhibitor EPZ-6438 Synergizes With Anti-Lymphoma Therapies In Preclinical Models

L. Danielle Johnston, Sarah Knutson, PhD, Natalie Warholic, Christine R Klaus, Tim J. Wigle, PhD, Dorothy Iwanowicz, Bruce A. Littlefield, PhD, Margaret Porter Scott, PhD, Jesse J Smith, PhD, Mikel P Moyer, PhD, Robert A. Copeland, PhD, Roy M. Pollock, PhD, Kevin W Kuntz, PhD, Heike Keilhack, PhD, Alejandra Raimondi
Journal: Blood
Blood (2013) 122 (21): 4416.
https://doi.org/10.1182/blood.V122.21.4416.4416
Published: 2013
Journal Articles

Preclinical Characterization of E7438, a Potent, Selective Inhibitor of Protein Methyltransferase EZH2 with Robust Antitumor Activity Against EZH2 Mutated Non-Hodgkin Lymphoma Xenografts in Mice

Heike Keilhack, PhD, Akira Yokoi, PhD, Sarah K Knutson, PhD, Tim Wigle, PhD, Natalie Warholic, Satoshi Kawano, PhD, Yukinori Minoshima, PhD, Kuan-Chun Huang, PhD, Galina Kuznetsov, PhD, Namita Kumar, Christine R Klaus, Christina J Allain, Alejandra Raimondi, PhD, Margaret Porter Scott, PhD, Richard Chesworth, DPhil, Mikel P Moyer, PhD, Toshimitsu Uenaka, PhD, Robert A Copeland, PhD, Victoria M Richon, PhD, Roy M Pollock, PhD, Kevin W Kuntz, PhD
Journal: Blood
Blood (2012) 120 (21): 3712.
https://doi.org/10.1182/blood.V120.21.3712.3712
Published: 2012
Journal Articles

Mechanism of Oncogenesis by Leukemia-Associated Mutants of Shp2 (PTPN11).

M. Golam Mohi, Ph.D, Heike Keilhack, Ph.D., Sarah Cohen, Christina Boulton, Toshiyuki Araki, Ph.D., Ifor Williams, M.D., Ph.D., Jeffery L. Kutok, M.D., Ph.D., D. Gary Gilliland, M.D., Ph.D., Benjamin G. Neel, M.D., Ph.D.
Journal: Blood
Blood (2004) 104 (11): 199.
https://doi.org/10.1182/blood.V104.11.199.199
Published: 2004