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Journal Articles

CD38 Enzymatic Activity Modulates Drug Susceptibility in Multiple Myeloma Cells

Yawara Kawano, Junzhe Bai, Saki Kushima, Hiroyuki Hata, Jun-ichirou Yasunaga

Blood (2024) 144 (Supplement 1): 6833.

https://doi.org/10.1182/blood-2024-211662

Published: 2024

Journal Articles

The Role of CD38 in Multiple Myeloma Cell Biology

Yawara Kawano, Saki Kushima, Hiroyuki Hata, Masao Matsuoka

Blood (2021) 138 (Supplement 1): 1580.

https://doi.org/10.1182/blood-2021-150884

Published: 2021

Journal Articles

The Presence and Possible Role of Virus-Host Chimeric Transcripts in Adult T-Cell Leukemia-Lymphoma

Hiroo Katsuya, MD, Paola Miyazato, PhD, Saiful Islam, Benjy Jek Yang Tan, MD, Yuki Inada, Misaki Matsuo, Takaharu Ueno, Masahito Tokunaga, MD PhD, Hiroyuki Hata, MD PhD, Makoto Yamagishi, PhD, Jun-Ichi Fujisawa, Toshiki Watanabe, MD, PhD, Kaoru Uchimaru, MD, PhD, Atae Utsunomiya, MD, Shinya Kimura, MD PhD, Yorifumi Satou, MD PhD

Blood (2019) 134 (Supplement_1): 2779.

https://doi.org/10.1182/blood-2019-124361

Published: 2019

Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2019) 134 (Supplement_1): 3097.

https://doi.org/10.1182/blood-2019-125756

Published: 2019

Journal Articles

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

Saki Kushima, Takayuki Sasano, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1810.

https://doi.org/10.1182/blood-2019-123624

Published: 2019

Journal Articles

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

Takayuki Sasano, Saki Kushima, Matsushita Yutaka, Masao Matsuoka, MD PhD, Hiroyuki Hata, MD PhD, Yawara Kawano, MD PhD

Blood (2019) 134 (Supplement_1): 1814.

https://doi.org/10.1182/blood-2019-123619

Published: 2019

Journal Articles

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Yawara Kawano, MD PhD, Yuki Inada, Takayuki Sasano, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2018-99-118603

Published: 2018

Journal Articles

Possible Involvement of YB-1 in Abnormal Nuclear Shape of Adult T-Cell　Leukemia/Lymphoma Cell

Misaki Kakoki, Hiroo Katsuya, MD, Paola Miyazato, PhD, Takafumi Noguchi, Yuki Inada, Misaki Matsuo, Hiroyuki Hata, MDPhD, Tokio Tani, Yorifumi Satou, MD PhD

Blood (2017) 130 (Supplement 1): 5150.

https://doi.org/10.1182/blood.V130.Suppl_1.5150.5150

Published: 2017

Journal Articles

Altered Expression of CCR10 Indicates Malignant Transformation of Bone Marrow Plasma Cells

Yawara Kawano, MD PhD, Misaki Kakoki, Yuki Inada, Nao Nishimura, MD, Yutaka Okuno, MD, PhD, Hiroyuki Hata, MDPhD, Masao Matsuoka, MDPhD

Blood (2017) 130 (Supplement 1): 1782.

https://doi.org/10.1182/blood.V130.Suppl_1.1782.1782

Published: 2017

Journal Articles

Highly Sensitive Viral RNA-Seq Is a Powerful Tool to Analyze the Viral Transcripts in HTLV-1-Infected Individuals

Yuki Inada, Hiroo Katsuya, MD, Paola Miyazato, PhD, Benjy Jek Yang Tan, MD, Saori Iwase, Misaki Kakoki, Misaki Matsuo, Saiful Islam, Masahito Tokunaga, MD, Hiroyuki Hata, MDPhD, Yoshihisa Yamano, MD, Atae Utsunomiya, MD, Yorifumi Satou, MD PhD

Blood (2017) 130 (Supplement 1): 2484.

https://doi.org/10.1182/blood.V130.Suppl_1.2484.2484

Published: 2017

Journal Articles

Identification of a Compound Overcoming Drug Resistance of Myeloma Cells at Hypoxic Condition

Eri Fujii, MT, Yuki Inada, Misaki Kakoki, Nao Nishimura, MD, Shinya Endo, MD, Shiho Fujiwara, MD, Naoko Wada, MD, Yawara Kawano, MD PhD, Yutaka Okuno, MD, PhD, Toshiya Sugimoto, MT, Hiroyuki Hata, MD PhD

Blood (2017) 130 (Supplement 1): 5395.

https://doi.org/10.1182/blood.V130.Suppl_1.5395.5395

Published: 2017

Journal Articles

Amyloid Fibril Formation of Immunoglobulin Light Chain Peptide from IHC-Negative AL Amyloidosis and Its Inhibition By Doxycycline and Epigallocatechin

Hiroyuki Hata, MD PhD, Toshiya Sugimoto, MT, Mitsuharu Ueda, MD, PhD, Nao Nishimura, MD, Shinya Endo, Yutaka Okuno, MD, PhD, Taro Yamashita, Konen Obayashi, MD, PhD, Masayoshi Tasaki, PhD, Eri Fujii, MT, Yuuki Inada, Misaki Kakoki, Yukio Ando, MD, PhD

Blood (2017) 130 (Supplement 1): 5331.

https://doi.org/10.1182/blood.V130.Suppl_1.5331.5331

Published: 2017

Journal Articles

Xenograft Models of Multiple Myeloma Reveal That PU.1 Serves As a Tumor Suppressor for Multiple Myeloma

Nao Nishimura, MD, Shinya Endo, MD, Niina Ueno, MD, Shikiko Ueno, MD PhD, Hiromichi Yuki, MD PhD, Hiroyuki Hata, MD PhD, Hiroaki Mitsuya, MD PhD, Yutaka Okuno, MD PhD

Blood (2014) 124 (21): 2047.

https://doi.org/10.1182/blood.V124.21.2047.2047

Published: 2014

Journal Articles

Conditional Knockout of Sfpi1 in Post GC B and Plasma Cells Induces B Cell Lymphoma and Plasma Cell Neoplasm

Shinya Endo, MD, Hiromichi Yuki, MD PhD, Yoshihiro Komohara, MD PhD, Shikiko Ueno, MD PhD, Nao Nishimura, MD, Niina Ueno, MD, Hiro Tatetsu, MD PhD, Motohiro Takeya, MD PhD, Hiroyuki Hata, MD PhD, Seiji Okada, MD PhD, Daniel G. Tenen, MD, Hiroaki Mitsuya, MD PhD, Yutaka Okuno, MD PhD

Blood (2014) 124 (21): 29.

https://doi.org/10.1182/blood.V124.21.29.29

Published: 2014

Journal Articles

Deposition of Lambda Chain Constant Region within AL-Amyloid Lesion

Hiroyuki Hata, MD PhD, Masayoshi Tasaki, Konen Obayashi, MD PhD, Taro Yamashita, MD PhD, Yukio Ando, MD PhD, Shinya Endo, MD, Nao Nishimura, MD, Yutaka Okuno, MD PhD, Shiho Fujiwara, MD PhD, Naoko Wada, MD, Eri Fujii, Kennichi Iyama, MD PhD, Hiroaki Mitsuya, MD PhD

Blood (2014) 124 (21): 3348.

https://doi.org/10.1182/blood.V124.21.3348.3348

Published: 2014

Journal Articles

Lactate Is a Crucial Energy Source For Multiple Myeloma (MM) Cells In Bone Marrow Microenvironment

Shiho Fujiwara, MD, Naoko Wada, MD, Yawara Kawano, MD, PhD, Yoshitaka Kikukawa, MD PhD, Hiroaki Mitsuya, MD PhD, Hiroyuki Hata, MD, PhD

Blood (2013) 122 (21): 3109.

https://doi.org/10.1182/blood.V122.21.3109.3109

Published: 2013

Journal Articles

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

Naoko Wada, MD, Yawara Kawano, MD, PhD, Shiho Fujiwara, MD, Yoshitaka Kikukawa, MD, PhD, Yutaka Okuno, MD, PhD, Hiroaki Mitsuya, MD, PhD, Hiroyuki Hata, MD, PhD

Blood (2013) 122 (21): 3172.

https://doi.org/10.1182/blood.V122.21.3172.3172

Published: 2013

Journal Articles

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Hiromichi Yuki, Shikiko Ueno, Hiro Tatetsu, Hiroaki Niiro, Tadafumi Iino, Shinya Endo, Yawara Kawano, Yoshihiro Komohara, Motohiro Takeya, Hiroyuki Hata, Seiji Okada, Toshiki Watanabe, Koichi Akashi, Hiroaki Mitsuya, Yutaka Okuno

Blood (2013) 121 (6): 962–970.

https://doi.org/10.1182/blood-2012-05-431429

Published: 2013

Includes: Supplemental data

Journal Articles

Clinical Profile of Multiple Myeloma in Asia - an Asian Myeloma Network (AMN) Study

Blood (2012) 120 (21): 5035.

https://doi.org/10.1182/blood.V120.21.5035.5035

Published: 2012

Journal Articles

Hypoxia Reduces CD138 Expression and Induces Immature Phenotype in Myeloma Cells

Yawara Kawano, MD, Shiho Fujiwara, MD, Naoko Wada, MD, Hiromichi Yuki, MD, Hiroaki Mitsuya, MD, PhD, Hiroyuki Hata, MD, PhD

Blood (2012) 120 (21): 3956.

https://doi.org/10.1182/blood.V120.21.3956.3956

Published: 2012

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CD38 Enzymatic Activity Modulates Drug Susceptibility in Multiple Myeloma Cells

The Role of CD38 in Multiple Myeloma Cell Biology

The Presence and Possible Role of Virus-Host Chimeric Transcripts in Adult T-Cell Leukemia-Lymphoma

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Targeting Nicotinamide Adenine Dinucleotide (NAD) Glycohydrase Activity of CD38 Exerts Anti-Myeloma Effect Accompanying Intracellular NAD Elevation

JX06, a Novel PDK1 Inhibitor, Induces Myeloma Cell Apoptosis By Metabolic Reprogramming and Works Synergistically with Bortezomib

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Possible Involvement of YB-1 in Abnormal Nuclear Shape of Adult T-Cell　Leukemia/Lymphoma Cell

Altered Expression of CCR10 Indicates Malignant Transformation of Bone Marrow Plasma Cells

Highly Sensitive Viral RNA-Seq Is a Powerful Tool to Analyze the Viral Transcripts in HTLV-1-Infected Individuals

Identification of a Compound Overcoming Drug Resistance of Myeloma Cells at Hypoxic Condition

Amyloid Fibril Formation of Immunoglobulin Light Chain Peptide from IHC-Negative AL Amyloidosis and Its Inhibition By Doxycycline and Epigallocatechin

Xenograft Models of Multiple Myeloma Reveal That PU.1 Serves As a Tumor Suppressor for Multiple Myeloma

Conditional Knockout of Sfpi1 in Post GC B and Plasma Cells Induces B Cell Lymphoma and Plasma Cell Neoplasm

Deposition of Lambda Chain Constant Region within AL-Amyloid Lesion

Lactate Is a Crucial Energy Source For Multiple Myeloma (MM) Cells In Bone Marrow Microenvironment

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Clinical Profile of Multiple Myeloma in Asia - an Asian Myeloma Network (AMN) Study

Hypoxia Reduces CD138 Expression and Induces Immature Phenotype in Myeloma Cells

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American Society of Hematology

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