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Journal Articles

Odronextamab Monotherapy for the Treatment of Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL): Focus on Clinical Pharmacology and Pharmacometrics in the ELM-1 and ELM-2 Studies

Min Zhu, Daniela Conrado, Kamal Srinivasan, Jurriaan Brouwer-Visser, Hong Yan, Hesham Mohamed, Aafia Chaudhry, Srikanth Ambati, Lutz Harnisch, John D Davis

Blood (2023) 142 (Supplement 1): 1436.

https://doi.org/10.1182/blood-2023-180675

Published: 2023

Journal Articles

Evaluate Dynamics of IL-6 Release during Step-up Dosing of Subcutaneous Administration of Odronextamab Via a Quantitative Systems Pharmacology Modeling Approach

Masood Khaksar Toroghi, Min Zhu, Srikanth R. Ambati, Hesham Mohamed, Aafia Chaudhry, Hong Yan, John D. Davis, A. Thomas DiCioccio

Blood (2022) 140 (Supplement 1): 11912–11913.

https://doi.org/10.1182/blood-2022-158413

Published: 2022

Journal Articles

Modeling and Simulation in Support of Odronextamab Subcutaneous Dose Selection for Adult Patients with Indolent or Aggressive Non-Hodgkin Lymphoma

Min Zhu, Srikanth R. Ambati, Hesham Mohamed, Masood Khaksar Toroghi, Hong Yan, Aafia Chaudhry, John D. Davis

Blood (2022) 140 (Supplement 1): 11579–11580.

https://doi.org/10.1182/blood-2022-158409

Published: 2022

Journal Articles

Selection of Odronextamab Pediatric Dosing Regimens for Aggressive Non-Hodgkin Lymphoma Via a Modeling and Simulation Approach

Min Zhu, Michael Dodds, Srikanth R. Ambati, Hesham Mohamed, Jason Chittenden, Hong Yan, Aafia Chaudhry, John D. Davis

Blood (2022) 140 (Supplement 1): 8855–8856.

https://doi.org/10.1182/blood-2022-158416

Published: 2022

Journal Articles

Optimization of Intravenous Odronextamab Step-up Regimen for Reducing the Risk of High-Grade Cytokine Release Syndrome

Min Zhu, Jurriaan Brouwer-Visser, Srikanth R. Ambati, Hesham Mohamed, Vladimir Jankovic, Fang Wang, Hong Yan, Jingxian Cai, Carolina Leite De Oliveira, Melanie Ufkin, John D. Davis, Aafia Chaudhry, Masood Khaksar Toroghi

Blood (2022) 140 (Supplement 1): 11560–11561.

https://doi.org/10.1182/blood-2022-158415

Published: 2022

Journal Articles

Restoring Dysfunctional Bone Marrow Endothelial Cell Alleviates Aplastic Anemia

Shu-Qian Tang, Wei-Li Yao, Hong-Yan Zhao, Qi Wen, Yuan-Yuan Zhang, Zhong-Shi Lyu, Tong Xing, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong

Blood (2021) 138 (Supplement 1): 202.

https://doi.org/10.1182/blood-2021-146152

Published: 2021

Journal Articles

Endothelial Cell Dysfunction Is Involved in the Progression of Myelodysplastic Syndromes

Tong Xing, Zhong-Shi Lyu, Cai-Wen Duan, Qi Wen, Hong-Yan Zhao, Shu-Qian Tang, Yuan-Yuan Zhang, Meng Lv, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong

Blood (2021) 138 (Supplement 1): 3668.

https://doi.org/10.1182/blood-2021-147663

Published: 2021

Journal Articles

M2 Macrophages, but Not M1 Macrophages, Support Megakaryopoiesis Via up-Regulating PI3K-AKT Pathway

Hong-Yan Zhao, PhD, Qi Wen, MD, Zhong-Shi Lyu, Shu-Qian Tang, Yuan-Yuan Zhang, Meng Lyu, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Yuan Kong, Xiao-Jun Huang

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-136562

Published: 2020

Journal Articles

Different Subsets of Haematopoietic Cells and Immune Cells in Bone Marrow between Young and Old Donors

Weili Yao, Qi Wen, MD, Hong-Yan Zhao, PhD, Yuan-Yuan Zhang, Shuqian Tang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao Jun Huang, Yuan Kong

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-134758

Published: 2020

Journal Articles

M1 and M2 Macrophages Play Different Roles in the Pathogenesis of Acute Graft-Versus-Host Disease Post-Allotransplant By Modulating Immune Microenvironment

Qi Wen, MD, Hong-Yan Zhao, PhD, Zhong-Shi Lyu, Yao Weili, Ting-Ting Han, Yu-Hong Chen, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Yuan Kong, Xiao-Jun Huang

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-136021

Published: 2020

Journal Articles

Glycolysis Restoration Attenuates Damaged Bone Marrow Endothelial Cells

Zhong-Shi Lyu, PhD, Wei-Li Yao, Qi Wen, MD, Hong-Yan Zhao, MD, Fei-Fei Tang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Hsiang-Ying Lee, PhD, Xiao-Jun Huang, Yuan Kong, MD PhD

Blood (2019) 134 (Supplement_1): 2491.

https://doi.org/10.1182/blood-2019-122794

Published: 2019

Journal Articles

Autophagy in Endothelial Cells Regulates Their Hematopoiesis Supporting Ability

Yuan Kong, MD PhD, Xie-Na Cao, Zhong-Shi Lyu, PhD, Xiao-Dong Mo, Qi Wen, MD, Hong-Yan Zhao, MD, Yu-Hong Chen, Yu Wang, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang

Blood (2019) 134 (Supplement_1): 4425.

https://doi.org/10.1182/blood-2019-122227

Published: 2019

Journal Articles

An Unbalanced Monocyte Macrophage Polarization in the Bone Marrow Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

Hong-Yan Zhao, Song Yang, Ting-Ting Han, Qi Wen, Min-Min Shi, Yu Wang, Lan-Ping Xu, Xiaohui Zhang, MD, Xiao-Jun Huang, MD, Yuan Kong

Blood (2017) 130 (Supplement 1): 3563.

https://doi.org/10.1182/blood.V130.Suppl_1.3563.3563

Published: 2017

Journal Articles

Impaired Bone Marrow Endothelial Progenitor Cells May Contribute to Acute Graft-Versus-Host Disease after Allotransplant

Xie-Na Cao, Yuan Kong, Song Yang, Min-Min Shi, Hong-Yan Zhao, Qi Wen, Yu Wang, Lan-Ping Xu, Xiaohui Zhang, MD, Xiao-Jun Huang, MD

Blood (2017) 130 (Supplement 1): 4440.

https://doi.org/10.1182/blood.V130.Suppl_1.4440.4440

Published: 2017

Journal Articles

N-Acetyl-L-Cysteine Improves Mesenchymal Stem Cell Function in Prolonged Isolated Thrombocytopenia Post-Allotransplant

Yuan Kong, Song Yang, Fei-Fei Tang, Hong-Yan Zhao, Yu-Hong Chen, Wei Han, Chen-Hua Yan, Yu Wang, Xiaohui Zhang, MD, Xiao-Jun Huang, MD

Blood (2017) 130 (Supplement 1): 4449.

https://doi.org/10.1182/blood.V130.Suppl_1.4449.4449

Published: 2017

Journal Articles

Impact of Chemotherapy Delay on Overall Survival for AML with I DH1/2 Mutations: A Study in Adult Chinese Patients

Blood (2015) 126 (23): 4905.

https://doi.org/10.1182/blood.V126.23.4905.4905

Published: 2015

Journal Articles

Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA

Even Holth Rustad, Hong Yan Dai, PhD, Eivind Coward, PhD, Kristine Misund, PhD, Anders Sundan, PhD, Anders Waage, MD PhD

Blood (2015) 126 (23): 4196.

https://doi.org/10.1182/blood.V126.23.4196.4196

Published: 2015

Journal Articles

Clinical and Biological Implications of BRAF V600E Mutation in Multiple Myeloma

Even Holth Rustad, Hong Yan Dai, PhD, Haakon Hov, MDPhD, Eivind Coward, PhD, Vidar Beisvag, PhD, Ola Myklebost, MDPhD, Eivind Hovig, PhD, Sigve Nakken, PhD, Daniel Vodák, Leonardo A Meza-Zepeda, PhD, Arne K Sandvik, MDPhD, Karin Fahl Wader, MD PhD, Kristine Misund, PhD, Anders Sundan, PhD, Harald Aarset, MDPhD, Anders Waage, MD PhD

Blood (2014) 124 (21): 5685.

https://doi.org/10.1182/blood.V124.21.5685.5685

Published: 2014

Journal Articles

P53 is Activated without RPL11 Upregulation in Diamond-Blackfan Anemia,

Hong-Yan Du, MD, PhD, M. Tarek Elghetany, MD, Blanche P Alter, MD, MPH, Akiko Shimamura, MD, PhD

Blood (2011) 118 (21): 3432.

https://doi.org/10.1182/blood.V118.21.3432.3432

Published: 2011

Journal Articles

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements

Hong-Yan Du, Elena Pumbo, Jennifer Ivanovich, Ping An, Richard T. Maziarz, Ulrike M. Reiss, Deborah Chirnomas, Akiko Shimamura, Adrianna Vlachos, Jeffrey M. Lipton, Rakesh K. Goyal, Frederick Goldman, David B. Wilson, Philip J. Mason, Monica Bessler

Blood (2009) 113 (2): 309–316.

https://doi.org/10.1182/blood-2008-07-166421

Published: 2009

Includes: Supplemental data

NARROW

Odronextamab Monotherapy for the Treatment of Relapsed/Refractory (R/R) Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL): Focus on Clinical Pharmacology and Pharmacometrics in the ELM-1 and ELM-2 Studies

Evaluate Dynamics of IL-6 Release during Step-up Dosing of Subcutaneous Administration of Odronextamab Via a Quantitative Systems Pharmacology Modeling Approach

Modeling and Simulation in Support of Odronextamab Subcutaneous Dose Selection for Adult Patients with Indolent or Aggressive Non-Hodgkin Lymphoma

Selection of Odronextamab Pediatric Dosing Regimens for Aggressive Non-Hodgkin Lymphoma Via a Modeling and Simulation Approach

Optimization of Intravenous Odronextamab Step-up Regimen for Reducing the Risk of High-Grade Cytokine Release Syndrome

Restoring Dysfunctional Bone Marrow Endothelial Cell Alleviates Aplastic Anemia

Endothelial Cell Dysfunction Is Involved in the Progression of Myelodysplastic Syndromes

M2 Macrophages, but Not M1 Macrophages, Support Megakaryopoiesis Via up-Regulating PI3K-AKT Pathway

Different Subsets of Haematopoietic Cells and Immune Cells in Bone Marrow between Young and Old Donors

M1 and M2 Macrophages Play Different Roles in the Pathogenesis of Acute Graft-Versus-Host Disease Post-Allotransplant By Modulating Immune Microenvironment

Glycolysis Restoration Attenuates Damaged Bone Marrow Endothelial Cells

Autophagy in Endothelial Cells Regulates Their Hematopoiesis Supporting Ability

An Unbalanced Monocyte Macrophage Polarization in the Bone Marrow Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic Stem Cell Transplantation

Impaired Bone Marrow Endothelial Progenitor Cells May Contribute to Acute Graft-Versus-Host Disease after Allotransplant

N-Acetyl-L-Cysteine Improves Mesenchymal Stem Cell Function in Prolonged Isolated Thrombocytopenia Post-Allotransplant

Impact of Chemotherapy Delay on Overall Survival for AML with I DH1/2 Mutations: A Study in Adult Chinese Patients

Detection and Monitoring of BRAF and NRAS Mutant Clones in Myeloma Patients By Digital PCR of Circulating DNA

Clinical and Biological Implications of BRAF V600E Mutation in Multiple Myeloma

P53 is Activated without RPL11 Upregulation in Diamond-Blackfan Anemia,

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements

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American Society of Hematology

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ASH Publications

American Society of Hematology

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