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Hongying Zhang, MD PhD
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Journal Articles

A Phase 1 a/b Dose Escalation Trial to Evaluate the Safety and Tolerability of CG-806 in Patients with Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas

Stephen B Howell, MD, Hongying Zhang, MD PhD, William G Rice, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5477.
https://doi.org/10.1182/blood-2019-130784
Published: 2019
Journal Articles

A Phase 1a/b Dose Escalation Study of Apto-253 in Patients with Relapsed or Refractory AML or High-Risk MDS

Stephen B Howell, MD, Hongying Zhang, MD PhD, William G Rice, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5148.
https://doi.org/10.1182/blood-2019-129685
Published: 2019
Journal Articles

Synthetic Lethal Interaction between Apto-253 and IDH1/2 Mutations

Cheng-Yu Tsai, PhD, Hongying Zhang, MD PhD, William G Rice, PhD, Stephen B Howell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5755.
https://doi.org/10.1182/blood-2019-123571
Published: 2019
Journal Articles

CG-806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broad Signaling Inhibition in Chronic Lymphocytic Leukemia Cells

Ekaterina Kim, MS, Hongying Zhang, MD PhD, Mariela Sivina, Alicia Vaca, PhD, Philip A. Thompson, MBBS, Nitin Jain, MD, Alessandra Ferrajoli, MD, Zeev E. Estrov, MD, Michael J Keating, MBBS, William G. Wierda, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD, Jan A. Burger, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3051.
https://doi.org/10.1182/blood-2019-124473
Published: 2019
Journal Articles

Synergistic Targeting of BTK and E-Selectin/CXCR4 in the Microenvironment of Mantle Cell Lymphomas

Mahesh Basyal, Weiguo Zhang, MD PhD, Nalini B Patel, Sujan Piya, PhD, Hongying Zhang, MD PhD, William E. Fogler, PhD, William G Rice, PhD, John L. Magnani, PhD, Gautam M. Borthakur, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3802.
https://doi.org/10.1182/blood-2019-126030
Published: 2019
Journal Articles

CG'806, a First-in-Class Pan-FLT3/Pan-BTK Inhibitor, Exhibits Broader and Greater Potency Than Ibrutinib Against Primary and Cultured Malignant B Cells

Hongying Zhang, MD, PhD, Andrea Local, PhD, Khalid Benbatoul, BS, Peter Folger, BS, Susan Sheng, PhD, Taryn McLaughlin, MS, Alexey V Danilov, MD PhD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Stephen Howell, MD, William G Rice, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3503.
https://doi.org/10.1182/blood-2018-99-117285
Published: 2018
Journal Articles

Concomitant Targeting of FLT3 and BTK with CG'806 Overcomes FLT3-Inhibitor Resistance through Inhibition of Autophagy

Weiguo Zhang, MD PhD, Guopan Yu, MD, PhD, Hongying Zhang, MD, PhD, Charlie Ly, BS, Bin Yuan, Vivian Ruvolo, MS, Sujan Piya, PhD, Seemana Bhattacharya, PhD, Qi Zhang, PhD, Gautam Borthakur, MD, Venkata Lokesh Battula, PhD, Marina Y. Konopleva, MD PhD, William G Rice, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2635.
https://doi.org/10.1182/blood-2018-99-116643
Published: 2018
Journal Articles

Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia

Hongying Zhang, MD PhD, Andrea Local, PhD, Khalid Benbatoul, Peter Folger, Susan Sheng, PhD, Luis Esquivies, PhD, Jeff Lightfoot, PhD, Avanish Vellanki, William G. Rice, PhD
Journal: Blood
Blood (2016) 128 (22): 1716.
https://doi.org/10.1182/blood.V128.22.1716.1716
Published: 2016
Journal Articles

Mechanisms of Resistance to Apto-253

Cheng-Yu Tsai, PhD, Hongying Zhang, MD PhD, Andrea Local, PhD, William G. Rice, PhD, Stephen B Howell, MD
Journal: Blood
Blood (2016) 128 (22): 5247.
https://doi.org/10.1182/blood.V128.22.5247.5247
Published: 2016
Journal Articles

Clinical Pharmacokinetics of Apto-253 Support Its Use As a Novel Agent for the Treatment of Relapsed or Refractory Hematologic Malignancies

William G. Rice, PhD, Jeff Lightfoot, PhD, Hongying Zhang, MD PhD, Tiffany Cheng, MSc, Avanish Vellanki, Robert Peralta, MSc, DVM, Stephen B Howell, MD, Andrea Local, Fannie Chau, Luis Esquivies
Journal: Blood
Blood (2015) 126 (23): 4934.
https://doi.org/10.1182/blood.V126.23.4934.4934
Published: 2015