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Journal Articles

Evaluation of a Bifunctional Sirpα-CD123 Fusion Antibody for the Elimination of Acute Myeloid Leukemia Stem Cells

Siret Tahk, Saskia Schmitt, Christian Peter Augsberger, Binje Vick, PhD, Laia Pascual Ponce, PhD, Irmela Jeremias, MD PhD, Georg Wittmann, MD, Nadja Fenn, PhD, Marion Subklewe, MD, Karl-Peter Hopfner, PhD

Blood (2019) 134 (Supplement_1): 2544.

https://doi.org/10.1182/blood-2019-128145

Published: 2019

Journal Articles

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Ehsan Bahrami, PhD, Martin Becker, PhD, Anna-Katharina Wirth, MSc, Jan Phillip Schmid, MSc, Tobias Herold, MD, Rupert Öllinger, PhD, Roland Rad, Irmela Jeremias, MD PhD

Blood (2019) 134 (Supplement_1): 3945.

https://doi.org/10.1182/blood-2019-124288

Published: 2019

Journal Articles

Single Cell Clones Derived from a Patient's AML Xenograft Display Genetic and Functional Heterogeneity

Christina Maria Zeller, MSc, Daniel Richter, MSc, Binje Vick, PhD, Tobias Herold, MD, Johannes Bagnoli, Maja Rothenberg-Thurley, PhD, Klaus H. Metzeler, MD, Karsten Spiekermann, MD, Wolfgang Enard, PhD, Irmela Jeremias, MD PhD

Blood (2019) 134 (Supplement_1): 1450.

https://doi.org/10.1182/blood-2019-127867

Published: 2019

Journal Articles

Loss of KDM6A Confers Drug Resistance in Acute Myeloid Leukemia

Sophie M. Stief, M.Sc., Anna-Li Hanneforth, Raphael Mattes, Sabrina Weser, M.Sc., Binje Vick, PhD, Michael D. Bartoschek, M.Sc., Helena Domínguez Moreno, M.Sc., Wen-Hsin Liu, PhD, Bianka Ksienzyk, Maja Rothenberg-Thurley, PhD, Hilmar Quentmeier, PhD, Wolfgang Hiddemann, Klaus H. Metzeler, MD, Gunnar Schotta, PhD, Sebastian Bultmann, PhD, Irmela Jeremias, MD PhD, Heinrich Leonhardt, PhD, Karsten Spiekermann, MD

Blood (2018) 132 (Supplement 1): 3935.

https://doi.org/10.1182/blood-2018-99-114959

Published: 2018

Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou

Blood (2018) 132 (Supplement 1): 2615.

https://doi.org/10.1182/blood-2018-99-118827

Published: 2018

Journal Articles

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, PhD MSc, Fotini Vogiatzi, PhD, Michela Carlet, PhD, Christian Vokuhl, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Irmela Jeremias, MD PhD, Stephan Fuhrmann, MD, Elias Hobeika, PhD, Hassan Jumaa, Prof. Dr., Ameera Alsadeq, PhD, Denis Martin Schewe, MD

Blood (2018) 132 (Supplement 1): 386.

https://doi.org/10.1182/blood-2018-99-114595

Published: 2018

Journal Articles

Long-Term Dormant Cells in Acute Myeloid Leukemia Patient-Derived Xenografts Display Reversible Treatment Resistance, but Are Not Enriched for Leukemia-Initiating Cells

Sarah Ebinger, MSc, Binje Vick, PhD, Karsten Spiekermann, MD, Irmela Jeremias, MD PhD

Blood (2018) 132 (Supplement 1): 1518.

https://doi.org/10.1182/blood-2018-99-109731

Published: 2018

Journal Articles

Peptide-Receptor Radiotherapy with CXCR4-Targeting Pentixather Reduces Leukemia Burden in Acute Leukemia PDX and Patients

Stefan Habringer, MD, Peter Herhaus, Margret Schottelius, PhD, Constantin Lapa, MD, Rouzanna Istvanffy, PhD, Katharina Götze, Katja Steiger, DVM, Binje Vick, PhD, Christian Peschel, MD, Robert Oostendorp, PhD, Irmela Jeremias, MD, Hans-Jürgen Wester, PhD, Goetz Ulrich Grigoleit, MD, Ulrich Keller, MD

Blood (2016) 128 (22): 4055.

https://doi.org/10.1182/blood.V128.22.4055.4055

Published: 2016

Journal Articles

Clones with and without Sensitivity Towards Treatment In Vivo Co-Exist within the Tumor Cells of a Single Patient with ALL

Cornelia Finkenzeller, MSc, Michela Carlet, PhD, Sebastian Vosberg, Christoph Ziegenhain, MSc, Martin Neumann, MD, Kristoffer Riecken, PhD, Kerstin Cornils, PhD, Boris Fehse, PhD, Claudia D. Baldus, MD, Wolfgang Enard, Prof. Dr. rer. nat., Philipp A. Greif, MD, Irmela Jeremias, MD

Blood (2016) 128 (22): 456.

https://doi.org/10.1182/blood.V128.22.456.456

Published: 2016

Journal Articles

Hypomethylating Agents and Casein Kinase 2 Inhibitor Act Synergistic and Reveal Significant Anti-Leukemic Effects in Acute Lymphoblastic Leukemia Cells

Catrin Roolf, PhD, Anna Richter, M.Sc., Christoph Konkolefski, Yascha Khodamoradi, Gudrun Knuebel, Anett Sekora, Jan Stenzel, PhD, Bernd Joachim Krause, MD, Brigitte Vollmar, MD, Irmela Jeremias, MD, Jens P. Panse, MD, Hugo Murua Escobar, PhD, Christian Junghanss, MD

Blood (2016) 128 (22): 2804.

https://doi.org/10.1182/blood.V128.22.2804.2804

Published: 2016

Journal Articles

Drug Resistance and Dormancy Represent Reversible Characteristics in Patients' ALL Cells Growing in Mice

Erbey Ziya Özdemir, MSc, Sarah Ebinger, MSc, Christoph Ziegenhain, MSc, Wolfgang Enard, Prof. Dr. rer. nat., Olivier Gires, Prof. Dr. rer. nat., Aloys Schepers, PD. Dr., Irmela Jeremias, MD

Blood (2016) 128 (22): 602.

https://doi.org/10.1182/blood.V128.22.602.602

Published: 2016

Journal Articles

Targeting the ER-Mitochondrial Interface of Cell Death Sensitizes Leukemia Cells Towards Cytostatics

Fabian Koczian, Jan Vomacka, Binje Vick, PhD, Britta F Hettich, Uli Kazmaier, Stephan A Sieber, Irmela Jeremias, MD, Angelika M Vollmar, Simone Braig

Blood (2016) 128 (22): 2319.

https://doi.org/10.1182/blood.V128.22.2319.2319

Published: 2016

Journal Articles

Tyrosin Kinase Inhibition Restores the Membrane Localization of FLT3-ITD

Katrin S. Reiter, Harald Polzer, PhD, Christina Krupka, Binje Vick, PhD, Andreas Maiser, Marion S. Subklewe, MD, Irmela Jeremias, MD, Heinrich Leonhardt, PhD, Karsten Spiekermann, MD, Philipp A. Greif, MD

Blood (2015) 126 (23): 1274.

https://doi.org/10.1182/blood.V126.23.1274.1274

Published: 2015

Journal Articles

Functional Diversity of Single Stem Cell Clones in Patients' Acute Lymphoblastic Leukemia Growing in Mice: An Adverse Subclone with Distinct DNA-Methylation Pattern, Slow Growth In Vivo and Drug Resistance

Cornelia Finkenzeller, M.Sc., Michela Carlet, PhD, Sebastian Vosberg, Philipp A. Greif, MD, Irmela Jeremias, MD

Blood (2015) 126 (23): 3062.

https://doi.org/10.1182/blood.V126.23.3062.3062

Published: 2015

Journal Articles

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Mark A. Murakami, MD MA, Alexandra N. Christodoulou, M.S., Amanda L Christie, B.S., Tiffany DeSouza, B.S., Abner Louissaint, Jr., MD PhD, Una Vojinovic, B.S., Raphael Koch, MD, Loretta S. Li, MD, Scott P. Kallgren, PhD, Prakash Rao, PhD, Johannes Köster, PhD, Raga Vadhi, M.S., Eilene Duberow, B.S., Elizabeth A. Morgan, MD, Hongjun Wang, Samia S. Ahmed, Katharine L. Majewski, Marina Konopleva, MD PhD, Jerome Tamburini, MD, PhD, Alejandro Gutierrez, MD, Michelle Kelliher, PhD, Julia Etchin, PhD, Irmela Jeremias, MD, Andrew P. Weng, MD PhD, Andrew L Kung, MD PhD, Andrew A Lane, MD PhD, Francine Garnache-Ottou, PhD, Shai Izraeli, MD Prof, Eric Jacobsen, MD, Ilene Galinsky, ANP, Richard M. Stone, MD, Marian H. Harris, MD PhD, David M. Dorfman, MD PhD, Jon C Aster, MDPhD, Henry Long, PhD, Lewis B. Silverman, MD, David M Weinstock, MD

Blood (2015) 126 (23): 3252.

https://doi.org/10.1182/blood.V126.23.3252.3252

Published: 2015

Journal Articles

Single Cell RNA Sequencing Reveals Increased Adhesion Signals in Treatment-Resistant Tumor Stem Cells in a Preclinical Mouse Model of Genetically Engineered Patient-Derived Acute Lymphoblastic Leukemia

Ebinger Sarah, M. Sc., Özdemir Erbey, M. Sc., Sebastian Tiedt, PhD, Christoph Ziegenhain, M. Sc., Catarina Castro Alves, PhD, Wolfgang Enard, Prof. Dr. rer. nat., Irmela Jeremias, MD

Blood (2015) 126 (23): 2630.

https://doi.org/10.1182/blood.V126.23.2630.2630

Published: 2015

Journal Articles

The Novel Technique of Genetically Engineered Patient-Derived Xenografts (GEPDX) Reveals That the X-Linked Inhibitor of Apoptosis Protein (XIAP) Plays an Essential Role for Maintenance and Growth of Patients' Acute Lymphoblastic Leukemia In Vivo

Michela Carlet, PhD, Jenny Vergalli, M.Sc., Cornelia Finkenzeller, M.Sc., Michaela Grunert, PhD, Irmela Jeremias, MD

Blood (2015) 126 (23): 2632.

https://doi.org/10.1182/blood.V126.23.2632.2632

Published: 2015

Journal Articles

Azacitidine in Combination with the Selective FLT3 Kinase Inhibitor Crenolanib Effectively Disrupts Stromal Protection of CD34+ Leukemia-Initiating Cells (LIC) in FLT3-ITD+ Acute Myeloid Leukemia (AML)

Anne-Kathrin Garz, M.Sc., Stefan Habringer, Saskia Wolf, Binje Vick, PhD, Marie-Theresa Weickert, M.Sc., Irmela Jeremias, MD, Karsten Spiekermann, MD, Christian Peschel, MD, Robert A.J. Oostendorp, PhD, Ulrich Keller, Katharina S. Götze, MD

Blood (2015) 126 (23): 676.

https://doi.org/10.1182/blood.V126.23.676.676

Published: 2015

Journal Articles

Bioluminescence in Vivo Imaging Improves the Model of Individual Patients' AML Cells Growing in Mice for Sensitive and Reliable Preclinical Treatment Trials on Various Genetic Subgroups

Irmela Jeremias, MD, Binje Vick, Dr., Maya Rothenberg, Nadine Sandhöfer, MSc, Michela Carlet, PhD, Christina Krupka, Andreas Trumpp, PhD, Selim Corbacioglu, MD, Martin Ebinger, MD, Maya Caroline Andre, MD, Wolfgang Hiddemann, MD, Stephanie Schneider, PhD, Marion Subklewe, MD, Klaus H Metzeler, MD, Karsten Spiekermann, MD

Blood (2014) 124 (21): 2323.

https://doi.org/10.1182/blood.V124.21.2323.2323

Published: 2014

Journal Articles

Key Nodes In FLT3 Dependent Signaling Determine Growth and Survival Of Childhood Acute Lymphoblastic Leukemia

Kevin Dierck, PhD, Ina Siekmann, MSc, Sebastian Prall, PhD, Florian Beck, MSc, Irmela Jeremias, MD, Albert Sickmann, PhD, Martin A. Horstmann, MD

Blood (2013) 122 (21): 2508.

https://doi.org/10.1182/blood.V122.21.2508.2508

Published: 2013

NARROW

Evaluation of a Bifunctional Sirpα-CD123 Fusion Antibody for the Elimination of Acute Myeloid Leukemia Stem Cells

A CRISPR/Cas9 Library Screen in Patients' Leukemia Cells In Vivo

Single Cell Clones Derived from a Patient's AML Xenograft Display Genetic and Functional Heterogeneity

Loss of KDM6A Confers Drug Resistance in Acute Myeloid Leukemia

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Long-Term Dormant Cells in Acute Myeloid Leukemia Patient-Derived Xenografts Display Reversible Treatment Resistance, but Are Not Enriched for Leukemia-Initiating Cells

Peptide-Receptor Radiotherapy with CXCR4-Targeting Pentixather Reduces Leukemia Burden in Acute Leukemia PDX and Patients

Clones with and without Sensitivity Towards Treatment In Vivo Co-Exist within the Tumor Cells of a Single Patient with ALL

Hypomethylating Agents and Casein Kinase 2 Inhibitor Act Synergistic and Reveal Significant Anti-Leukemic Effects in Acute Lymphoblastic Leukemia Cells

Drug Resistance and Dormancy Represent Reversible Characteristics in Patients' ALL Cells Growing in Mice

Targeting the ER-Mitochondrial Interface of Cell Death Sensitizes Leukemia Cells Towards Cytostatics

Tyrosin Kinase Inhibition Restores the Membrane Localization of FLT3-ITD

Functional Diversity of Single Stem Cell Clones in Patients' Acute Lymphoblastic Leukemia Growing in Mice: An Adverse Subclone with Distinct DNA-Methylation Pattern, Slow Growth In Vivo and Drug Resistance

Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma

Single Cell RNA Sequencing Reveals Increased Adhesion Signals in Treatment-Resistant Tumor Stem Cells in a Preclinical Mouse Model of Genetically Engineered Patient-Derived Acute Lymphoblastic Leukemia

The Novel Technique of Genetically Engineered Patient-Derived Xenografts (GEPDX) Reveals That the X-Linked Inhibitor of Apoptosis Protein (XIAP) Plays an Essential Role for Maintenance and Growth of Patients' Acute Lymphoblastic Leukemia In Vivo

Azacitidine in Combination with the Selective FLT3 Kinase Inhibitor Crenolanib Effectively Disrupts Stromal Protection of CD34+ Leukemia-Initiating Cells (LIC) in FLT3-ITD+ Acute Myeloid Leukemia (AML)

Bioluminescence in Vivo Imaging Improves the Model of Individual Patients' AML Cells Growing in Mice for Sensitive and Reliable Preclinical Treatment Trials on Various Genetic Subgroups

Key Nodes In FLT3 Dependent Signaling Determine Growth and Survival Of Childhood Acute Lymphoblastic Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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