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Jack M Heath
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Journal Articles

Prime Editing Enables Precise and Efficient Single Amino Acid Substitutions to Shield CD34+ Hematopoietic Stem Cells from Anti-CD117 Antibody-Based Conditioning

Jack M Heath, Justin G Tedeschi, Upasana Sunil Arvindam, Simran Padhye, Kanut Laoharawee, Allen C Ng, David P Waterman, Matthew S Roy, Seth C Alexander, Sarah Trusiak, Christopher Divsalar, Azhaar Alturkistani, Barrett J Nehilla, Mallik R Putta, Katya Kosheleva, Hetal K Patel, Rowshon Alam, Stefanie Urlinger, Jeremy S Duffield, Jennifer L Gori
Journal: Blood
Blood (2024) 144 (Supplement 1): 514.
https://doi.org/10.1182/blood-2024-203602
Published: 2024
Journal Articles

Prime Editing Efficiently and Precisely Corrects Causative Mutation in Chronic Granulomatous Disease, Restoring Myeloid Function: Toward Development of a Prime Edited Autologous Hematopoietic Stem Cell Therapy

Jack M Heath, Jacob Stuart Orenstein, Justin G Tedeschi, Allen Ng, Maria D Collier, Julia Kushakji, Alan J Wilhelm, Andrew Taylor, David P Waterman, Suk See De Ravin, Harry L Malech, Andrew V Anzalone, Jeremy S Duffield, Jennifer L Gori
Journal: Blood
Blood (2023) 142 (Supplement 1): 7129.
https://doi.org/10.1182/blood-2023-186365
Published: 2023
Journal Articles

Precise and Efficient Crispr/Cas9 Mediated Gene Editing in Long-Term Engrafting Human Hematopoietic Stem/Progenitor Cells

Jack M Heath, BS, Aditi Chalishazar, MS, Christina S Lee, BA, William Selleck, BS, Cecilia Cotta-Ramusino, PhD, David Bumcrot, PhD, Jennifer L Gori, PhD
Journal: Blood
Blood (2016) 128 (22): 2312.
https://doi.org/10.1182/blood.V128.22.2312.2312
Published: 2016