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James Downing
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Journal Articles

IDH1 and IDH2 Mutations In Pediatric Acute Myeloid Leukemia

Anna Andersson, PhD, David Miller, John Lynch, PhD, Andrew Lemoff, Zhongling Cai, Stanley Pounds, PhD, Ina Radtke, MD, PhD, Yan Bing, PhD, Schuetz John, PhD, Rubnitz Jeffrey, MD, PhD, Raul Ribeiro, MD, Susana C. Raimondi, PhD, Jinghui Zhang, PhD, Sheila Shurtleff, PhD, Brenda Schulman, PhD, James Downing, MD
Journal: Blood
Blood (2010) 116 (21): 1699.
https://doi.org/10.1182/blood.V116.21.1699.1699
Published: 2010
Journal Articles

Children with t(12;21)/TEL-AML1-Positive Acute Lymphoblastic Leukemia Exhibit a Distinct Germline Genomic Signature.

Lisa R. Trevino, PhD, Wenjian Yang, Ph.D., Stephen Hunger, M.D., William L. Carroll, M.D., Meenakshi Devidas, Ph.D., Cheryl L. Willman, M.D., James Downing, M.D., William E. Evans, PharmD, Ching-Hon Pui, M.D., Mary V. Relling, PharmD
Journal: Blood
Blood (2007) 110 (11): 760.
https://doi.org/10.1182/blood.V110.11.760.760
Published: 2007
Journal Articles

An International Multi-Center Study To Define the Application of Microarrays in the Diagnosis and Subclassification of Leukemia (MILE Study): Interim Analysis Based on 1,889 Patients Achieves 95.4% Prediction Accuracy.

Torsten Haferlach, MD, Alexander Kohlmann, PhD, Giuseppe Basso, PhD, Marie-Christine Bene, PhD, James Downing, PhD, Sheilla Shurtleff, PhD, Jesus M. Hernandez, MD, Wolf-Karsten Hofmann, MD, Thomas J. Kipps, PhD, Truus te Kronnie, PhD, Wei-Min Liu, PhD, Rui Li, Elisabeth Macintyre, PhD, Claude Preudhomme, PhD, Sabina Chiaretti, MD, Laura Rassenti, PhD, John de Vos, PhD, Allen Yeoh, MD, Charlotte Brown, PhD, Mickey Williams, PhD, Ken Mills, PhD, Lothar Wieczorek, Robert Foa, PhD
Journal: Blood
Blood (2006) 108 (11): 103.
https://doi.org/10.1182/blood.V108.11.103.103
Published: 2006
Journal Articles

Genome-Wide Single Nucleotide Polymorphism Analysis in Juvenile Myelomonocytic Leukemia Uncovers Long-Range Uniparental Disomy Surrounding the NF1 Locus in Cases Associated with Type 1 Neurofibromatosis but Not in Cases with Mutant RAS or PTPN11 .

Christian Flotho, MD, Doris Steinemann, PhD, Gudrun Göhring, MD, Charles Mullighan, MD, Geoffrey Neale, PhD, Brigitte Schlegelberger, MD, James Downing, MD, Charlotte Marie Niemeyer, MD
Journal: Blood
Blood (2006) 108 (11): 1453.
https://doi.org/10.1182/blood.V108.11.1453.1453
Published: 2006
Journal Articles

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

Patrick Brown, Mark Levis, Sheila Shurtleff, Dario Campana, James Downing, Donald Small
Journal: Blood
Blood (2005) 105 (2): 812–820.
https://doi.org/10.1182/blood-2004-06-2498
Published: 2005
Journal Articles

FLT3-Targeted Therapy Selectively Kills MLL-Rearranged Infant and Childhood ALL Blasts In Vitro and in Vivo.

Patrick Brown, MD, Obdulio Piloto, Mark Levis, MD PhD, Sheila Shurtleff, PhD, Dario Campana, MD PhD, James Downing, MD, Donald Small, MD PhD
Journal: Blood
Blood (2004) 104 (11): 686.
https://doi.org/10.1182/blood.V104.11.686.686
Published: 2004
Journal Articles

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis

Gianluigi Zaza, Wenjian Yang, Leo Kager, Meyling Cheok, James Downing, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, William E. Evans
Journal: Blood
Blood (2004) 104 (5): 1435–1441.
https://doi.org/10.1182/blood-2003-12-4306
Published: 2004
Includes: Supplemental data