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James R. Lerma
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Journal Articles

Therapeutic Targeting of FLT3 Gate Keeper Mutation with E2082-0047 in Traditional and a Novel Immunocompetent Murine Adoptive Transfer Model of AML

Ola A. Elgamal, Juan Carlos Zapata, Haishan Li, Chia Sharpe, Sydney Fobare, Blaise Stearns, James R. Lerma, Kinsey Bryant, Casie Furby, Marissa Long, Kaytlynn Fyock, Megan E. Johnstone, Thomas M. Sesterhenn, Benjamin Wronowski, Jianmin Pan, Shesh N. Rai, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Kate Dokukina, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Daniel T. Starczynowski, Amy Burd, C. David Pauza, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1544.
https://doi.org/10.1182/blood-2023-189259
Published: 2023
Journal Articles

Genome-Wide Methylome and Transcriptome Profiling of Acute Myeloid Leukemia Derived Bone Marrow Mesenchymal Cells Identify Age Group Specific Biological Pathway Dysregulation in the Bone Marrow Microenvironment of AML

Amina Abdul-Aziz, James R. Lerma, Amy Kovacs, Shesh N. Rai, Jianmin Pan, Liang Niu, Alice Mims, Christopher C. Oakes, John C. Byrd, Erin K. Hertlein
Journal: Blood
Blood (2023) 142 (Supplement 1): 5620.
https://doi.org/10.1182/blood-2023-189973
Published: 2023
Journal Articles

A Novel Selective BCL2 Inhibitor with Limited Immune Suppression and Improved Safety Compared to Venetoclax

Chia Sharpe, Sara Elgamal, Sydney Fobare, Casie Furby, Marissa Long, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Megan E. Johnstone, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Volodymyr Kysil, Hovhannes Gukasyan, Oleg Mitkin, Ruben Karapetian, Alexey Ryakhovskiy, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Kate Dokukina, Alexei Pushechnikov, Nikolay Savchuk, Iain Dukes, Amy Burd, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 4153.
https://doi.org/10.1182/blood-2023-189266
Published: 2023
Journal Articles

Development of a Fully Immunocompetent Adoptive Transfer In Vivo Model of Npm1 cA ;Idh2 R140Q ;Flt3 ITD AML

Chia Sharpe, Mariah Johnson, Sydney Fobare, Ola A. Elgamal, Bonnie K. Harrington, Allison Mustonen, Kinsey Bryant, Carolyn Cheney, James R. Lerma, Jean Truxall, Casie Furby, Marissa Long, Kaytlynn Fyock, Alan Shih, Ross L Levine, Erin K. Hertlein, John C. Byrd
Journal: Blood
Blood (2023) 142 (Supplement 1): 1386.
https://doi.org/10.1182/blood-2023-189975
Published: 2023
Journal Articles

A Novel Inhibitor of FLT3 and Its Drug-Resistant Mutants with Superior Activity to Gilteritinib in Molm-13 Preclinical Acute Myeloid Leukemia Xenograft Model

Ola A Elgamal, James R Lerma, Allison Mullaney, Emily Stahl, Blaise Stearns, Andrew Orry, Polo Chun-Hung Lam, Ruben Abagyan, Alexei Pushechnikov, Nikolay Savchuk, Volodymyr Kysil, Hovhannes Gukasyan, Iain Dukes, Oleg Mitkin, Ruben Karapetian, Alexei Riakhovskii, Elena Bulanova, Vladislav Parchinsky, Alexandre Ivachtchenko, Sharyn Baker, Erin Hertlein, John C. Byrd
Journal: Blood
Blood (2022) 140 (Supplement 1): 3352–3353.
https://doi.org/10.1182/blood-2022-165675
Published: 2022