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Jean-Charles Portais
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Journal Articles

Catabolic Flexibility Enhances Drug Resistance but Induces Selective Vulnerability to New Mitochondrial-Targeted Therapeutic Combinations in IDH Mutant Leukemia

Jean-Emmanuel Sarry, PhD, Christian Recher, MD PhD, Lucille Stuani, PhD, Jean-Charles Portais, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5238.
https://doi.org/10.1182/blood-2018-99-112523
Published: 2018
Journal Articles

Utilization of a-Ketoglutarate for Synthesis of 2-Hydroxyglutarate Oncometabolite Promotes Catabolic Flexibility, Redox Perturbation and Mitochondrial Activity That Supports Chemoresistance in IDH1 Mutant Acute Myeloid Leukemia

Lucille Stuani, PhD, Christian Recher, MD PhD, Jean-Charles Portais, PhD, Jean-Emmanuel Sarry, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5080.
https://doi.org/10.1182/blood.V130.Suppl_1.5080.5080
Published: 2017
Journal Articles

The Combination of ATRA and Dasatinib for Differentiation Therapy in Acute Myeloid Leukemias with IDH Mutations

Helena Boutzen, PharmD PhD, Estelle Saland, Mathilde Cathebras, Clément Larrue, PhD, Thomas Farge, Nizar Serhan, PhD, Fabienne De Toni, PhD, Marion David, PhD, Lara Gales, Florence Castelli, Christophe Junot, PhD, Eric Delabesse, PharmD PhD, Demas Veronique, PharmD PhD, Jean-Charles Portais, PhD, Ouathek Ouerfelli, PhD, Yang Guangli, PhD, Francois Vergez, VD PhD, Christian Recher, MDPhD, Jean-Emmanuel Sarry, PhD
Journal: Blood
Blood (2015) 126 (23): 2542.
https://doi.org/10.1182/blood.V126.23.2542.2542
Published: 2015
Journal Articles

Metabolic Capability to Induce the Pasteur Effect Mediates Sensitivity of Human Leukemic Cells to Metformin

Sarah Scotland, Estelle Saland, Lindsay Peyriga, Rémi Peyraud, Elizabeth Micklow, Gwenn Danet-Desnoyers, Stéphane Manenti, Christian Récher, Jean-Charles Portais, Mary Selak, Martin Carroll, MD, Jean-Emmanuel Sarry, PhD
Journal: Blood
Blood (2011) 118 (21): 2601.
https://doi.org/10.1182/blood.V118.21.2601.2601
Published: 2011