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Jesus San Miguel, MDPhD
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Journal Articles

Whole-Genome Analysis of the Chromatin Structure in Multiple Myeloma

Marta Kulis, Raquel Ordoñez, Nuria Russiñol, Renée Beekman, Núria Verdaguer-Dot, Teresa Ezponda, Arantxa Carrasco, Joost H.A. Martens, Hendrik G. Stunnenberg, Bruno Paiva, PhD, Jesus San Miguel, MDPhD, Elias Campo, Felipe Prosper, MD, Xabier Agirre, PhD, José I. Martin-Subero
Journal: Blood
Blood (2016) 128 (22): 118.
https://doi.org/10.1182/blood.V128.22.118.118
Published: 2016
Journal Articles

The Presence of MDS-like Phenotypic Abnormalities (MDS-PA) Identifies Newly Diagnosed Multiple Myeloma (MM) Patients with MDS/AML-Related Somatic Mutations and Inferior Survival

Bruno Paiva, PhD, Noemi Puig, MD PhD, Maria Teresa Cedena, Iria Vazquez, PhD, Carmen Chillon, Yanira Ruiz, Joaquin Martinez-Lopez, Ramon Garcia-Sanz, Marcos González, MD PhD, Xabier Agirre, PhD, Maria-Jose Calasanz, Leire Burgos, Diego Alignani, Felipe Prosper, MD, Sergio Matarraz, Alberto Orfao, MD PhD, Albert Oriol, MD, Ana Isabel Teruel, MD, M Asuncion Echeveste, Raquel De Paz, PhD, Felipe De Arriba, Miguel-T Hernandez, Gemma Azaceta, MD PhD, Rafael Martinez, MD, Maria-Victoria Mateos, MD PhD, Joan Bladé, Juan José Lahuerta, MD PhD, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2016) 128 (22): 375.
https://doi.org/10.1182/blood.V128.22.375.375
Published: 2016
Journal Articles

Low-Dose Dexamethasone Does Not Abrogate the Immunomodulatory Effects of Lenalidomide and Both Reactivate the Impaired Immune System of High-Risk Smoldering Multiple Myeloma Patients

Bruno Paiva, PhD, Maria-Victoria Mateos, Luis Ignacio Sánchez-Abarca, Maria Belen Vidriales, MD PhD, Lucia Lopez-Corral, MD, Luis A Corchete, Miguel T Hernandez, Joan Bargay, MD PhD, Felipe De Arriba, Javier De La Rubia, Ana Isabel Teruel, MD, Pilar Giraldo, MD PhD, Laura Rosiñol, MDPhD, Felipe Prosper, MD, Albert Oriol, MDPhD, Jose Mariano Hernandez, MD, Graça Esteves, Fernando Leal da Costa, Juan Jose Lahuerta, Joan Blade, MDPhD, Jose A. Perez-Simon, MD, PhD, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2955.
https://doi.org/10.1182/blood.V126.23.2955.2955
Published: 2015
Journal Articles

Prognostic Value of Immune Profiling Multiple Myeloma Patients during Minimal Residual Disease Monitoring in the Pethema/GEM2010MAS65 Study

Paula Arana, Bruno Paiva, PhD, Noemi Puig, MD PhD, Teresa Cedena, Lourdes Cordon, Maria Belen Vidriales, MD PhD, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MDPhD, Albert Oriol, MDPhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 721.
https://doi.org/10.1182/blood.V126.23.721.721
Published: 2015
Journal Articles

What Is the Frequency of Transplant-Eligible Multiple Myeloma Patients Being Cured? the Impact of an MGUS-like Signature at Diagnosis and MRD-Negativity

Bruno Paiva, PhD, Maria Belen Vidriales, MD PhD, Noemi Puig, MD PhD, Teresa Cedena, Lourdes Cordon, Maria-Victoria Mateos, Joaquin Martinez-López, MDPhD, Laura Rosiñol, MDPhD, Alfonso Garcia de Coca, MD PhD, Natalia De Las Heras, MD, Josefina Galende, Jose Mariano Hernandez, MD, Luis Palomera, MDPhD, Javier De La Rubia, Joan Blade, MDPhD, Jesus San Miguel, MDPhD, Juan Jose Lahuerta
Journal: Blood
Blood (2015) 126 (23): 725.
https://doi.org/10.1182/blood.V126.23.725.725
Published: 2015
Journal Articles

Characterization of Minimal Residual Disease

Alberto Orfao, MD PhD, Bruno Paiva, PhD, Juan Flores-Montero, MD, Noemi Puig, MD PhD, Laura Gutierrez, Ramon Garcia-Sanz, MD PhD, Maria-Victoria Mateos, Juan Jose Lahuerta, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): SCI-52.
https://doi.org/10.1182/blood.V126.23.SCI-52.SCI-52
Published: 2015
Journal Articles

Usefulness of Serum-Free-Light-Chains-Ratio (SFLCR) and Serum Heavy-Light-Chains-Ratio (SHLCR) in Multiple Myeloma in the Context of Three GEM/Pethema Clinical Trials

Lucia Lopez-Anglada, MDPhD, Cecilia Cueto-Felgueroso, Maria-Victoria Mateos, Laura Rosiñol, MDPhD, Albert Oriol, MDPhD, Ana Isabel Teruel, MD, Ana Lopez de la Guia, MD, Luis Palomera, MDPhD, Felipe de Arriba, MDPhD, Jose Mariano Hernandez, MD, Miquel Granell, MD, Francisco Javier Peñalver, MD, Ramon Garcia-Sanz, MDPhD, Juan Besalduch, MDPhD, Yolanda Gonzalez, MD, Rafael Martinez, MDPhD, Miguel Teodoro Hernandez, MDPhD, Norma C Gutierrez, Paloma Puerta, MD, Joan Blade, MDPhD, Jesús San Miguel, MDPhD, Juan José Lahuerta, MDPhD, Joaquin Martinez Lopez, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2962.
https://doi.org/10.1182/blood.V126.23.2962.2962
Published: 2015
Journal Articles

Next Generation Flow (NGF): A High Sensitive Technique to Detect Circulating Peripheral Blood (PB) Clonal Plasma Cells (cPC) in Patients with Newly Diagnosed of Plasma Cell Neoplasms (PCN)

*Luzalba Sanoja-Flores, M.Sc., *Bruno Paiva, PhD, Juan A Flores-Montero, MD, Noemi Puig, MD PhD, Leire Burgos, Omar García, PhD, Felipe Prosper, MD, Juana Merino, MDPhD, Maria Belen Vidriales, MD PhD, Maria-Victoria Mateos, Ramon Garcia, MD, Luis Palomera, MDPhD, Rafael Rios, María Consuelo Cañizo, MD PhD, Brian G M Durie, Jacques J.M. van Dongen, Jesus San Miguel, MDPhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4180.
https://doi.org/10.1182/blood.V126.23.4180.4180
Published: 2015
Journal Articles

The Relevance of Minimal Residual Disease (MRD) Monitoring in Elderly Multiple Myeloma (MM) Patients

Bruno Paiva, PhD, Teresa Cedena, Noemi Puig, MD PhD, Lourdes Cordon, Joaquin Martinez-López, MDPhD, Enrique M. Ocio, MD PhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Jesus Martin, Norma C Gutiérrez, Maria Belen Vidriales, MD PhD, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 4181.
https://doi.org/10.1182/blood.V126.23.4181.4181
Published: 2015
Journal Articles

Bortezomib Plus Melphalan and Prednisone (VMP) Followed By Lenalidomide and Dexamethasone (Rd) in Newly Diagnosed Elderly Myeloma Patients Overcome the Poor Prognosis of High-Risk Cytogenetic Abnormalities (CA) Detected By Fluorescence in Situ Hibridization (FISH)

Maria-Victoria Mateos, Norma C Gutierrez, María-Luisa Martín, Joaquín Martínez-López, MD PhD, Miguel T Hernandez, Rafael Martinez, MDPhD, Laura Rosiñol, MDPhD, Enrique M. Ocio, MD PhD, Ana Isabel Teruel, MD, Albert Oriol, MDPhD, Juan Jose Bargay, Enrique Bengoechea, Yolanda Gonzalez, MD, Jaime Perez De Oteyza, Mercedes Gironella, Cristina Encinas, Jesus Martin, Carmen Cabrera, Bruno Paiva, PhD, Noemi Puig, MD PhD, Joan Blade, MDPhD, Juan José Lahuerta, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 4243.
https://doi.org/10.1182/blood.V126.23.4243.4243
Published: 2015
Journal Articles

Bortezomib, Melphalan, Prednisone (VMP) and Lenalidomide Plus Dexamethasone (Rd) Is the Optimal Combination for Patients with Newly Diagnosed Multiple Myeloma (MM) Patients Between 65 and 80 Years

Maria-Victoria Mateos, MD PhD, Joaquín Martínez-López, Miguel T Hernandez, Enrique M Ocio, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Ana Isabel Teruel, MD, Norma C Gutierrez, María-Luisa Martín, Albert Oriol, MD, Joan Bargay, MD, Enrique Bengoechea, Yolanda Gonzalez, MD, Jaime Perez de Oteyza, Mercedes Gironella, Cristina Encinas, Carmen Cabrera, Bruno Paiva, PhD, Maria Teresa Cedena, Noemi Puig, MD PhD, Joan Blade, MDPhD, Juan José Lahuerta, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1848.
https://doi.org/10.1182/blood.V126.23.1848.1848
Published: 2015
Journal Articles

Eloquent-2 Update: A Phase 3, Randomized, Open-Label Study of Elotuzumab in Combination with Lenalidomide/Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma - 3-Year Safety and Efficacy Follow-up

Meletios A. Dimopoulos, Sagar Lonial, MD, Darrell White, MD, Philippe Moreau, Antonio Palumbo, MD, Jesus San Miguel, MDPhD, Ofer Shpilberg, MD MPH, Kenneth C. Anderson, MD, Sebastian Grosicki, MD PhD, Ivan Spicka, MD PhD, Adam Walter-Croneck, Hila Magen-Nativ, Maria-Victoria Mateos, Andrew Belch, Donna Reece, Meral Beksac, MD, Eric Bleickhardt, Valerie Poulart, Jessica Katz, Anil K. Singhal, Paul G. Richardson
Journal: Blood
Blood (2015) 126 (23): 28.
https://doi.org/10.1182/blood.V126.23.28.28
Published: 2015
Journal Articles

Simplified in-House Deep Sequencing Method of Inmunoglobulin Genes for Minimal Residual Dissease Quantification and Risk Stratification in Multiple Myeloma

Beatriz Sanchez-Vega, Santiago Barrio, Yanira Ruiz, Ramon Garcia-Sanz, MD PhD, Bruno Paiva, PhD, Carlos Marin, Roberto Maldonado, Inmaculada Rapado, Jose Cervera, MD, Rosa M. Ayala, MD PhD, Teresa Cedena, Cristina Jimenez, BsC, Miguel T Hernandez, Rafael Martinez, MD, Enrique M Ocio, M Asuncion Echeveste, Laura Rosinol, Joan Blade, Maria-Victoria Mateos, Jesus San Miguel, MDPhD, Juan Jose Lahuerta, MD PhD, Joaquin Martinez Lopez, MDPhD
Journal: Blood
Blood (2015) 126 (23): 2972.
https://doi.org/10.1182/blood.V126.23.2972.2972
Published: 2015
Journal Articles

Target Expression, Preclinical Activity and Mechanism of Action of EM801: A Novel First-in-Class Bcma T-Cell Bispecific Antibody for the Treatment of Multiple Myeloma

Anja Seckinger, MD, Jose Antonio Delgado, Laura Moreno, Brigitte Neuber, PhD, Anna Grab, PhD, Susanne Lipp, MS, Juana Merino, MDPhD, Minh Diem Vu, PhD, Klaus Strein, MD PhD, Felipe Prosper, MDPhD, Michael Hundemer, MD, Jesus San Miguel, MDPhD, Dirk Hose, MD, Bruno Paiva, PhD
Journal: Blood
Blood (2015) 126 (23): 117.
https://doi.org/10.1182/blood.V126.23.117.117
Published: 2015
Journal Articles

Prognostic Value of Antigen Expression in Multiple Myeloma (MM): A Large GEM/Pethema Study Based in Four Consecutive Clinical Trials

Bruno Paiva, PhD, Noemi Puig, MD PhD, Paula Arana, Teresa Cedena, Lourdes Cordon, Maria Belen Vidriales, MD PhD, Norma C Gutierrez, Joaquin Martinez-López, MDPhD, Miguel T Hernandez, Ana Isabel Teruel, MD, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, MDPhD, Rafael Martinez, MD, Albert Oriol, MDPhD, Javier De La Rubia, Joan Blade, MDPhD, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2015) 126 (23): 19.
https://doi.org/10.1182/blood.V126.23.19.19
Published: 2015
Journal Articles

A Dose Finding Phase II Trial of Isatuximab (SAR650984, Anti-CD38 mAb) As a Single Agent in Relapsed/Refractory Multiple Myeloma

Thomas Martin, MD, Joshua Richter, MD, Ravi Vij, MD, Craig Cole, MD, Djordje Atanackovic, MD, Jeffrey Zonder, MD, Jonathan L. Kaufman, MD, William Bensinger, MD, Meletios A. Dimopoulos, Jesús San Miguel, MDPhD, Todd Zimmerman, MD, Nikoletta Lendvai, MDPhD, Parameswaran Hari, MD MRCP, MS, Enrique M. Ocio, MD PhD, Cristina Gasparetto, MD, Shaji Kumar, MD, Karl Hsu, MD, Eric Charpentier, MSc, Stephen A. Strickland, MD, Joseph Mikhael, MD
Journal: Blood
Blood (2015) 126 (23): 509.
https://doi.org/10.1182/blood.V126.23.509.509
Published: 2015