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Journal Articles

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Tyler W. Stratton, MSc, Guangheng Zhu, MD, Yiming Wang, MD PhD, Pingguo Chen, PhD, Miguel A. D. Neves, PhD MSc, Reid C. Gallant, MSc, Peter A. A. Norris, BSc, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2018) 132 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2018-99-119964

Published: 2018

Journal Articles

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Jade Sullivan, BSc, Brigitta Elaine Oswald, B.Sc, Brian Vadasz, BSc, June Li, MSc, Pingguo Chen, PhD, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2017) 130 (Supplement 1): 233.

https://doi.org/10.1182/blood.V130.Suppl_1.233.233

Published: 2017

Journal Articles

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

June Li, MSc, Dianne Evertdina van der Wal, PhD, Guangheng Zhu, MD, Miao Xu, MSc, MD, Issaka Yougbare, PhD, Li Ma, PhD, Brian Vadasz, BSc, Renata Grozovsky, PhD, Min Ruan, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, Lili Tao, MD, Zhi-min Zhai, MD, Jun Peng, MD, Ming Hou, MD, Valery Leytin, PhD, John J. Freedman, MD, Karin M Hoffmeister, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 467.

https://doi.org/10.1182/blood.V124.21.467.467

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

Yan Yang, MD, PhD, Zhenyin Shi, MD, Adili Reheman, MD, Wuxun Jin, MD, PhD, Conglei Li, MD, Guangheng Zhu, MD, Yiming Wang, MD, John J. Freedman, MD, Wenhua Ling, MD, PhD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 3197.

https://doi.org/10.1182/blood.V116.21.3197.3197

Published: 2010

Journal Articles

The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Yuhan Chen, Michael Kim, Arata Tabuchi, Wolfgang M. Kuebler, MD, PhD, Rukhsana Aslam, PhD, John J. Freedman, MD, FRCPC, John W. Semple, PhD

Blood (2010) 116 (21): 3351.

https://doi.org/10.1182/blood.V116.21.3351.3351

Published: 2010

Journal Articles

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Elisa K. Simpson, H.B.Sc., Guangheng Zhu, MD, Conglei Li, MD, Lingyan Zhu, MD, Qingshu Zeng, MD, John W. Semple, PhD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 1433.

https://doi.org/10.1182/blood.V116.21.1433.1433

Published: 2010

Journal Articles

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Li Guo, Rukhsana Aslam, Edwin R Speck, Heyu Ni, Ming Hou, John J. Freedman, MD, FRCPC, John W. Semple, PhD

Blood (2010) 116 (21): 3686.

https://doi.org/10.1182/blood.V116.21.3686.3686

Published: 2010

Journal Articles

Plasma Fibronectin In Thrombosis and Hemostasis: Exploring the Fibrin Dependent and Independent Mechanisms

Yiming Wang, MD, Adili Reheman, MD, Jalil Kalantari, BSc, Wuxun Jin, MD, PhD, Peter L. Gross, MD, FRCPC, Margaret L. Rand, PhD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2010) 116 (21): 484.

https://doi.org/10.1182/blood.V116.21.484.484

Published: 2010

Journal Articles

The Role of ABO Blood Group In TTP Prevalence and Disease Outcome

Katerina Pavenski, MD, FRCP, Jordana Boro, John J. Freedman, MD, FRCPC, Marie B. Garvey, MD, Jerome M. Teitel, MD, FRCPC, Lisa Hicks, MD, MSc, FRCPC

Blood (2010) 116 (21): 4671.

https://doi.org/10.1182/blood.V116.21.4671.4671

Published: 2010

Journal Articles

Pregnancy-associated Thrombotic Thrombocytopenic Purpura: A Single Institution's Experience

Jordana Boro, Katerina Pavenski, MD, FRCP, John J. Freedman, MD, FRCPC, Marie B. Garvey, MD, Lisa K Hicks, MD, MSc, FRCPC

Blood (2010) 116 (21): 4675.

https://doi.org/10.1182/blood.V116.21.4675.4675

Published: 2010

Journal Articles

Platelet Apoptosis in Fluid-Phase and Adherent Platelets and Thrombi-Like Platelet Aggregates.

Valery Leytin, David J. Allen, Elena Lyubimov, Anna Chavlovski, Mingyu She, Sergiy Mykhaylov, Sergey P. Domogatsky, John J. Freedman

Blood (2007) 110 (11): 2102.

https://doi.org/10.1182/blood.V110.11.2102.2102

Published: 2007

Journal Articles

Anticoagulant Heparan Sulfate Mediates Antithrombin Amelioration of Leukocyte-Endothelial Interactions in Sepsis.

Peter L. Gross, MD, Bruno A. Esposito, BSc, John J. Freedman, MD, Sassan Hajmohammadi3, PhD, Nicholas W. Shworak3, MD, PhD

Blood (2005) 106 (11): 3684.

https://doi.org/10.1182/blood.V106.11.3684.3684

Published: 2005

Journal Articles

Platelet Apoptosis Events Can Be Triggered by Shear Stresses and Chemical Agonists.

Valery Leytin, PhD, Sergiy Mykhaylov, PhD, David J. Allen, BSc, John J. Freedman, MD

Blood (2005) 106 (11): 3940.

https://doi.org/10.1182/blood.V106.11.3940.3940

Published: 2005

Journal Articles

Chemical Agonists and High Shear Stress Induce Apoptosis in Human Platelets.

Valery Leytin, PhD, Sergiy Mykhaylov, PhD, David J. Allen, BSc, Lukasz Miz, BSc, Elena V. Lyubimov, PhD, Marie B. Garvey, MD, John J. Freedman, MD

Blood (2004) 104 (11): 3875.

https://doi.org/10.1182/blood.V104.11.3875.3875

Published: 2004

Journal Articles

Role of P-Selectin and GPIbα in the Fast and Delayed Clearance of Transfused Platelets.

Valery Leytin, PhD, David J. Allen, BSc, Adam Gwozdz, BSc, Marie B. Garvey, MD, John J. Freedman, MD

Blood (2004) 104 (11): 3625.

https://doi.org/10.1182/blood.V104.11.3625.3625

Published: 2004

NARROW

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Anthocyanins Inhibit Platelet Activation and Attenuate Thrombus Growth In Both Human and Murine Thrombosis Models

The Role of Recipient Platelets In the Prevention of Antibody-Mediated Transfusion Related Acute Lung Injury (TRALI)

Steroids Are Less Effective In Treating Thrombocytopenia Caused by Immune Responses Against Platelet GPIbα: A Comparative Study Using Passive and Active ITP Models.

Allogeneic Platelet MHC Class I Antigens Prevent CD61 Specific Cytotoxic T Cell (CTL)-Mediated Immune Thrombocytopenia (ITP).

Plasma Fibronectin In Thrombosis and Hemostasis: Exploring the Fibrin Dependent and Independent Mechanisms

The Role of ABO Blood Group In TTP Prevalence and Disease Outcome

Pregnancy-associated Thrombotic Thrombocytopenic Purpura: A Single Institution's Experience

Platelet Apoptosis in Fluid-Phase and Adherent Platelets and Thrombi-Like Platelet Aggregates.

Anticoagulant Heparan Sulfate Mediates Antithrombin Amelioration of Leukocyte-Endothelial Interactions in Sepsis.

Platelet Apoptosis Events Can Be Triggered by Shear Stresses and Chemical Agonists.

Chemical Agonists and High Shear Stress Induce Apoptosis in Human Platelets.

Role of P-Selectin and GPIbα in the Fast and Delayed Clearance of Transfused Platelets.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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