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John M. Higgins, MD
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Journal Articles

Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Erica B. Esrick, MD, Maureen Achebe, MD MPH, Myriam Armant, PhD, Pablo Bartolucci, MD PhD, Marioara Felicia Ciuculescu, MD, Heather Daley, Colleen Dansereau, MSN, RN, CPN, Giuseppe Di Caprio, PhD, Bronner Goncalves, MD PhD, Nicolas Hebert, Matthew M Heeney, MD, John M. Higgins, MD PhD, Leslie E. Lehmann, MD, John P Manis, MD, Olivier Negre, PhD, Sarah Nikiforow, MD PhD, Ethan Schonbrun, PhD, David K. Wood, PhD, David A. Williams, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-5.
https://doi.org/10.1182/blood-2019-132745
Published: 2019
Journal Articles

MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Melanie Demers, PhD, Sarah Sturtevant, BSc, Kevin Guertin, PhD, Dipti Gupta, Kunal Desai, MS, Benjamin Vieira, BS, Alexandra Hicks, PhD, Ayman Ismail, PhD, Yukio Nakamura, MD PhD, Bronner Goncalves, MD PhD, Giuseppe Di Caprio, PhD, Ethan Schonbrun, PhD, Scott Hansen, BS, Martin K. Safo, PhD, David K. Wood, PhD, John M. Higgins, MD PhD, David R. Light, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2260.
https://doi.org/10.1182/blood-2019-128727
Published: 2019
Journal Articles

Mathematical Modeling of White Blood Cell Population Dynamics for Diagnosis and Prognosis

Anwesha Chaudhury, PhD, Aliyah R Sohani, MD, John M. Higgins, MD
Journal: Blood
Blood (2016) 128 (22): 1333.
https://doi.org/10.1182/blood.V128.22.1333.1333
Published: 2016
Journal Articles

Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes

Siddhartha Jaiswal, MDPhD, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter Grauman, Brenton G. Mar, MDPhD, R. Coleman Lindsley, MDPhD, Craig Mermel, Noel Burtt, Alejandro Chavez, John M. Higgins, MD, Vladislav Moltchanov, Leena Kinnunen, Heikki Koistinen, Claes Ladenvall, Gad Getz, PhD, Adolfo Correa, Stacey Gabriel, PhD, Sekar Kathiresan, Heather Stringham, Michael Boehnke on behalf of GoT2D, Brian Henderson on behalf of SIGMA T2D, Mark McCarthy on behalf of T2D-GENES, Jaako Tuomilehto, Christopher A. Haiman, Sc.D., Leif Groop, Gil Atzmon, James Wilson, Donna S. Neuberg, ScD, David Altshuler, Benjamin L Ebert, MD PhD
Journal: Blood
Blood (2014) 124 (21): 840.
https://doi.org/10.1182/blood.V124.21.840.840
Published: 2014