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Jonathan D. Finn
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Journal Articles

New Hyperactive Factor IX Variants Bioengineered Based upon Biochemical Studies of Factor IX Padua

Ben J. Samelson-Jones, MD PhD, Jonathan D Finn, PhD, Rodney M. Camire, PhD, Valder R Arruda, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1384.
https://doi.org/10.1182/blood.V128.22.1384.1384
Published: 2016
Journal Articles

AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice

Julie M. Crudele, Jonathan D. Finn, Joshua I. Siner, Nicholas B. Martin, Glenn P. Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D. Lothrop, Jr, Valder R. Arruda
Journal: Blood
Blood (2015) 125 (10): 1553–1561.
https://doi.org/10.1182/blood-2014-07-588194
Published: 2015
Includes: Supplemental data
Journal Articles

Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs

Julie M Crudele, Jonathan D Finn, PhD, Nicholas B Martin, Joshua I Siner, Yifeng Chen, MD, Shangzhen Zhou, MD, Glenn Niemeyer, PhD, Clinton D. Lothrop, PhD, DVM, Federico Mingozzi, PhD., Katherine A. High, MD, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4203.
https://doi.org/10.1182/blood.V122.21.4203.4203
Published: 2013
Journal Articles

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8 + T cells

Ashley T. Martino, Etiena Basner-Tschakarjan, David M. Markusic, Jonathan D. Finn, Christian Hinderer, Shangzhen Zhou, David A. Ostrov, Arun Srivastava, Hildegund C. J. Ertl, Cox Terhorst, Katherine A. High, Federico Mingozzi, Roland W. Herzog
Journal: Blood
Blood (2013) 121 (12): 2224–2233.
https://doi.org/10.1182/blood-2012-10-460733
Published: 2013
Includes: Supplemental data
Journal Articles

The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy

Brief Report
Jonathan D. Finn, Timothy C. Nichols, Nikolaos Svoronos, Elizabeth P. Merricks, Dwight A. Bellenger, Shangshen Zhou, Paolo Simioni, Katherine A. High, Valder R. Arruda
Journal: Blood
Blood (2012) 120 (23): 4521–4523.
https://doi.org/10.1182/blood-2012-06-440123
Published: 2012
Journal Articles

CD8 + T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells

Jennifer D. Bassett, Teng Chih Yang, Dannie Bernard, James B. Millar, Stephanie L. Swift, A. J. Robert McGray, Heather VanSeggelen, Jeanette E. Boudreau, Jonathan D. Finn, Robin Parsons, Carole Evelegh, Daniela Damjanovic, Natalie Grinshtein, Maziar Divangahi, Liang Zhang, Zhou Xing, Yonghong Wan, Jonathan L. Bramson
Journal: Blood
Blood (2011) 117 (4): 1146–1155.
https://doi.org/10.1182/blood-2010-03-272336
Published: 2011
Includes: Supplemental data
Journal Articles

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Jonathan D. Finn, Margareth C. Ozelo, Denise E. Sabatino, Helen W. G. Franck, Elizabeth P. Merricks, Julie M. Crudele, Shangzhen Zhou, Haig H. Kazazian, David Lillicrap, Timothy C. Nichols, Valder R. Arruda
Journal: Blood
Blood (2010) 116 (26): 5842–5848.
https://doi.org/10.1182/blood-2010-06-288001
Published: 2010
Journal Articles

Naturally-Occurring Antibodies to Human AAV In Sheep: A New Large Animal Model for Immune Aspects of AAV Gene Transfer.

Joseph Tellez, Jonathan D. Finn, PhD, Nicholas Tschernia, Graca Almeida-Porada, MD, PhD, Valder Arruda, MD, PhD, Christopher D Porada, PhD
Journal: Blood
Blood (2010) 116 (21): 3762.
https://doi.org/10.1182/blood.V116.21.3762.3762
Published: 2010
Journal Articles

Rabbit Anti-Thymocyte Globulin (rATG) Administrated Concomitantly with Liver Delivery of AAV2-hFIX Can Promote Inhibitor Formation In Rhesus Macaques.

Jonathan D. Finn, PhD, Patricia Favaro, PhD, J. Fraser Wright, PhD, Federico Mingozzi, PhD., Katherine A. High, MD, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3765.
https://doi.org/10.1182/blood.V116.21.3765.3765
Published: 2010
Journal Articles

Suppression of CTL Responses against AAV-Capsid Epitopes by Peptide-Induced Regulatory T Cells.

Daniel J Hui, Ph.D., Gary C Pien, MD, PhD, Etiena Basner-Tschakarjan, M.D., Federico Mingozzi, PhD, Jonathan D Finn, PhD, Shangzhen Zhou, Ph.D., William Martin, Anne S. De Groot, M.D., Katherine A. High, MD
Journal: Blood
Blood (2009) 114 (22): 377.
https://doi.org/10.1182/blood.V114.22.377.377
Published: 2009
Journal Articles

FIX-R338L (FIX Padua) as a Successful Alternative for the Treatment of Canine Severe Hemophilia B.

Jonathan D Finn, PhD, Paolo Simioni, MD, PhD, Nicholas Iacobelli, B.Sc., Shangzhen Zhou, Timothy C. Nichols, MD, Katherine A. High, MD, Valder R. Arruda, M.D., Ph.D.
Journal: Blood
Blood (2009) 114 (22): 694.
https://doi.org/10.1182/blood.V114.22.694.694
Published: 2009
Journal Articles

Proteasome Inhibitors Decrease AAV2 Capsid-Derived Peptide Epitope Presentation On MHC Class I Following Transduction.

Jonathan D Finn, PhD, Daniel J Hui, Ph.D., Downey Harre, Danielle Dunn, Federico Mingozzi, PhD, Shangzhen Zhou, Katherine A. High, MD
Journal: Blood
Blood (2009) 114 (22): 695.
https://doi.org/10.1182/blood.V114.22.695.695
Published: 2009
Journal Articles

Induction of Immune Tolerance to Canine FVIII in Hemophilia a Dogs with Inhibitors Using AAV-Mediated Expression of Canine FVIII

Jonathan D Finn, PhD, Denise E Sabatino, PhD, Margareth C Ozelo, MD, Shangzhen Zhou, MD, David Lillicrap, MD, Haig H Kazazian, MD, Timothy C. Nichols, MD, Valder R. Arruda, M.D., Ph.D.
Journal: Blood
Blood (2008) 112 (11): 243.
https://doi.org/10.1182/blood.V112.11.243.243
Published: 2008