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Jonathan N. Thon
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Journal Articles

Novel Bone Marrow/HSC-Targeted, Megakaryocyte-Derived Extracellular Vesicle Delivery Modality for In Vivo Gene Therapy

Laura R Goldberg, Qiuyan W Ma, Navdeep Malik, Daniel Bode, Samik Das, Will Thompson, Jenna C Harris, Joseph R Inigo, Pragati Jain, Emily S Day, David M Raiser, Sedattin S Ozturk, Eleftherios T Papoutsakis, Iain R Thompson, Jonathan N. Thon
Journal: Blood
Blood (2023) 142 (Supplement 1): 2253.
https://doi.org/10.1182/blood-2023-179450
Published: 2023
Journal Articles

In Vitro Functionality of hiPSC Derived PLT+: The Utility of Microfluidic Assays in Determining Potency

Marcus Lehmann, PhD, Annie K Burton, Savannah G Szemethy, Jorge Valdez, PhD, Jonathan N. Thon, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1168.
https://doi.org/10.1182/blood-2019-131896
Published: 2019
Journal Articles

Investigating Potential Mechanism(s) By Which ASO-Based Drugs Cause Thrombocytopenia

Martina H. Lundberg Slingsby, PhD, Genevieve Couldwell, Prakrith Vijey, Brooke E Terkovich, Leila Noetzli, PhD, Ross Okazaki, Jonathan N. Thon, PhD, Scott P. Henry, PhD, Padmakumar Narayanan, DVM, PhD, Joseph E. Italiano, Jr., PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3747.
https://doi.org/10.1182/blood-2018-99-116590
Published: 2018
Journal Articles

CRISPR/Cas9-Mediated Diacylglycerol Kinase Knockout Potentiates Anti-Tumor Efficacy of Human Chimeric Antigen Receptor T-Cells

In-Young Jung, MS, Yoon-Young Kim, PhD, Ho-Sung Yu, MS, Seokjoong Kim, PhD, Jonathan N. Thon, PhD, Jungmin Lee, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3182.
https://doi.org/10.1182/blood.V130.Suppl_1.3182.3182
Published: 2017
Journal Articles

Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein

Markus Bender, Jonathan N. Thon, Allen J. Ehrlicher, Stephen Wu, Linas Mazutis, Emoke Deschmann, Martha Sola-Visner, Joseph E. Italiano, John H. Hartwig
Journal: Blood
Blood (2015) 125 (5): 860–868.
https://doi.org/10.1182/blood-2014-09-600858
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

Platelet bioreactor-on-a-chip

Jonathan N. Thon, Linas Mazutis, Stephen Wu, Joanna L. Sylman, Allen Ehrlicher, Kellie R. Machlus, Qiang Feng, Shijiang Lu, Robert Lanza, Keith B. Neeves, David A. Weitz, Joseph E. Italiano, Jr
Journal: Blood
Blood (2014) 124 (12): 1857–1867.
https://doi.org/10.1182/blood-2014-05-574913
Published: 2014
Includes: Multimedia, Supplemental data
Journal Articles

SDF-1 directs megakaryocyte relocation

Jonathan N. Thon
Journal: Blood
Blood (2014) 124 (2): 161–163.
https://doi.org/10.1182/blood-2014-05-571653
Published: 2014
Journal Articles

Proplatelet generation in the mouse requires PKCε-dependent RhoA inhibition

Giuliana Gobbi, Prisco Mirandola, Cecilia Carubbi, Elena Masselli, Stephen M. Sykes, Francesca Ferraro, Antonio Nouvenne, Jonathan N. Thon, Joseph E. Italiano, Jr, Marco Vitale
Journal: Blood
Blood (2013) 122 (7): 1305–1311.
https://doi.org/10.1182/blood-2013-04-490599
Published: 2013
Includes: Supplemental data
Journal Articles

Canonical Wnt signaling in megakaryocytes regulates proplatelet formation

Iain C. Macaulay, Jonathan N. Thon, Marloes R. Tijssen, Brian M. Steele, Bryan T. MacDonald, Gerardene Meade, Philippa Burns, Augusto Rendon, Vishal Salunkhe, Ronan P. Murphy, Cavan Bennett, Nicholas A. Watkins, Xi He, Desmond J. Fitzgerald, Joseph E. Italiano, Jr, Patricia B. Maguire
Journal: Blood
Blood (2013) 121 (1): 188–196.
https://doi.org/10.1182/blood-2012-03-416875
Published: 2013
Includes: Supplemental data
Journal Articles

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

Sylvia T. Nürnberg, Augusto Rendon, Peter A. Smethurst, Dirk S. Paul, Katrin Voss, Jonathan N. Thon, Heather Lloyd-Jones, Jennifer G. Sambrook, Marloes R. Tijssen, the HaemGen Consortium, Joseph E. Italiano, Jr, Panos Deloukas, Berthold Gottgens, Nicole Soranzo, Willem H. Ouwehand
Journal: Blood
Blood (2012) 120 (24): 4859–4868.
https://doi.org/10.1182/blood-2012-01-401893
Published: 2012
Includes: Supplemental data
Journal Articles

Megaloblastic Anemia and Mitochondriopathy Caused by a Homozygous Mutation in Sideroflexin-4.

Jeffrey D. Cooney, Gordon J. Hildick-Smith, Caterina Garone, M.D., Jonathan N. Thon, Ph.D., Orhan H. Akman, Ph.D., Caiyong Chen, Ph.D., Dhvanit I. Shah, Ph.D., Diana Santos Branco, M. Sc., Non Miyata, Ph.D., Matthew L. Freedman, M.D., Sarah E. Calvo, Ph.D., Vamsi K. Mootha, M.D., Carla M. Koehler, Ph.D., Joseph E. Italiano, Jr., PhD, M. Alice Donati, M.D., Salvatore DiMauro, M.D., Barry H. Paw, M.D., Ph.D.
Journal: Blood
Blood (2012) 120 (21): 79.
https://doi.org/10.1182/blood.V120.21.79.79
Published: 2012
Journal Articles

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

Elenoe C. Smith, Jonathan N. Thon, Matthew T. Devine, Sharon Lin, Vincent P. Schulz, Yanwen Guo, Stephanie A. Massaro, Stephanie Halene, Patrick Gallagher, Joseph E. Italiano, Jr, Diane S. Krause
Journal: Blood
Blood (2012) 120 (11): 2317–2329.
https://doi.org/10.1182/blood-2012-04-420828
Published: 2012
Includes: Supplemental data
Journal Articles

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production

Jonathan N. Thon, Matthew T. Devine, Antonija Jurak Begonja, Jay Tibbitts, Joseph E. Italiano, Jr
Journal: Blood
Blood (2012) 120 (10): 1975–1984.
https://doi.org/10.1182/blood-2012-04-420968
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

Does size matter in platelet production?

Jonathan N. Thon, Joseph E. Italiano, Jr
Journal: Blood
Blood (2012) 120 (8): 1552–1561.
https://doi.org/10.1182/blood-2012-04-408724
Published: 2012
Journal Articles

The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation

Sunita Patel-Hett, Hongbei Wang, Antonija J. Begonja, Jonathan N. Thon, Eva C. Alden, Nancy J. Wandersee, Xiuli An, Narla Mohandas, John H. Hartwig, Joseph E. Italiano, Jr
Journal: Blood
Blood (2011) 118 (6): 1641–1652.
https://doi.org/10.1182/blood-2011-01-330688
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

The mouse mutation “thrombocytopenia and cardiomyopathy” (trac) disrupts Abcg5 : a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia

Thomas H. Chase, Bonnie L. Lyons, Roderick T. Bronson, Oded Foreman, Leah Rae Donahue, Lisa M. Burzenski, Bruce Gott, Priscilla Lane, Belinda Harris, Uta Ceglarek, Joachim Thiery, Henning Wittenburg, Jonathan N. Thon, Joseph E. Italiano, Jr, Kenneth R. Johnson, Leonard D. Shultz
Journal: Blood
Blood (2010) 115 (6): 1267–1276.
https://doi.org/10.1182/blood-2009-05-219808
Published: 2010
Journal Articles

A Novel Marker for Blood Platelet Storage Lesion: Newly Synthesized Rap1 in Integrin Signaling.

Peter Schubert, PhD, Jonathan N. Thon, BSc, Geraldine M. Walsh, PhD, Katherine Serrano, PhD, Edwin D. Moore, PhD, Juergen Kast, PhD, Dana V. Devine, PhD
Journal: Blood
Blood (2007) 110 (11): 4020.
https://doi.org/10.1182/blood.V110.11.4020.4020
Published: 2007
Journal Articles

Comparative Proteome Analysis To Study Novel Markers of the Blood Platelet Lesion.

Peter Schubert, PhD, Jonathan N. Thon, Marie Duguay, Katherine Serrano, PhD, Dana V. Devine, PhD, Juergen Kast, PhD
Journal: Blood
Blood (2006) 108 (11): 951.
https://doi.org/10.1182/blood.V108.11.951.951
Published: 2006