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Journal Articles

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Abhishek K Singh, PhD, Karin Golan, PhD, Mark J Althoff, BS, Ekaterina Petrovich-Kopitman, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Mayla Bertagna, MSc, Daniel Gonzalez-Nieto, PhD, Luis C Barrio, MD PhD, Tsvee Lapidot, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 872.

https://doi.org/10.1182/blood-2018-99-118292

Published: 2018

Journal Articles

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Blood (2018) 132 (Supplement 1): 639.

https://doi.org/10.1182/blood-2018-99-118663

Published: 2018

Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 551.

https://doi.org/10.1182/blood-2018-99-118919

Published: 2018

Journal Articles

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Swarnava Roy, PhD, Parul Rai, MD, Marthe-Sandrine Eiymo Mwa Mpollo, PhD, Kyung-Hee Chang, PhD, Tilat Rizvi, Loberg Anastacia, Bruce J. Aronow, PhD, Tadashi Inagami, PhD, David Witte, MD, Jose A Cancelas, MD PhD, Punam Malik, MD

Blood (2017) 130 (Supplement 1): 440.

https://doi.org/10.1182/blood.V130.Suppl_1.440.440

Published: 2017

Journal Articles

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

Mark J Althoff, BS, Ramesh C. Nayak, PhD, Shailaja Hegde, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2017) 130 (Supplement 1): 710.

https://doi.org/10.1182/blood.V130.Suppl_1.710.710

Published: 2017

Journal Articles

TRAF6 Is Essential for Maintaining Hematopoietic Stem Cell Homeostasis

Jing Fang, MD PhD, Lyndsey Bolanos, BSc, Juana Serrano-Lopez, PhD, Susanne Christie, Jose A Cancelas, MD PhD, Daniel T Starczynowski, PhD

Blood (2016) 128 (22): 568.

https://doi.org/10.1182/blood.V128.22.568.568

Published: 2016

Journal Articles

Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial

Sherrill J. Slichter, MD, Larry J. Dumont, PhD MBA, Jose A. Cancelas, MD PhD, Terry Gernsheimer, MD, Zbigniew Szczepiorkowski, MD PhD, Nancy M. Dunbar, MD, Stephen Medlin, DO, FACP, MeLinh Jones, B.S., Neeta Rugg, M.S., Gautham Prakash, B.S., Greggory J. Housler, MSc, MBA, Victor W. MacDonald, PhD, Peter Hmel, M.S., Janet H. Ransom, PhD

Blood (2016) 128 (22): 1030.

https://doi.org/10.1182/blood.V128.22.1030.1030

Published: 2016

Journal Articles

Atypical Protein Kinase C λ/I Oncogenic Signaling through the Chromatin Modifier Satb2 Is Required for Leukemic B-Cell Progenitor Differentiation Arrest and Leukemogenesis

Ramesh C Nayak, Mark Jordan Althoff, BS, Ashley Wellendorf, Fatima Mohmoud, Maria Diaz-Meco, Jorge Moscat, Jose A. Cancelas, MD PhD

Blood (2016) 128 (22): 1201.

https://doi.org/10.1182/blood.V128.22.1201.1201

Published: 2016

Journal Articles

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Karin Golan, PhD, Ashley Wellendorf, Yuji Takihara, MD PhD, Anju Kumari, PhD, Eman Khatib-Massalha, Msc, Orit Kollet, PhD, Hui Cheng, PhD, Tao Cheng, MD, Mark J. Althoff, Shiri Gur-Cohen, PhD, Tomer Itkin, PhD, Marie-Dominique Fillipi, PhD, Jose A Cancelas, MD PhD, Toshio Suda, MD PhD, Tsvee Lapidot, PhD

Blood (2016) 128 (22): 5.

https://doi.org/10.1182/blood.V128.22.5.5

Published: 2016

Journal Articles

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Megha Desai, PhD, Kyung-Hee Chang, PhD, E. David Muench, BS, Anjelika Gasilina, Ashley Wellendorf, Xose R Bustelo, H. Leighton Grimes, PhD, Nicolas Nassar, PhD, Jose A Cancelas, MD PhD

Blood (2015) 126 (23): 3661.

https://doi.org/10.1182/blood.V126.23.3661.3661

Published: 2015

Journal Articles

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

Juana Serrano-Lopez, PhD, Josefina Serrano, Cuiping Zhang, MD PhD, Ashley Wellendorf, Jing Fang, MDPhD, Joaquin Sanchez-Garcia, H. Leighton Grimes, PhD, Daniel T Starczynowski, PhD, Jose A Cancelas, MD PhD

Blood (2015) 126 (23): 785.

https://doi.org/10.1182/blood.V126.23.785.785

Published: 2015

Journal Articles

EGFR Signaling in Osteoblasts Regulates Circadian Rhythm of HSPC in Circulation

Sachin Kumar, PhD, Jeff Vassallo, PhD, Kalpana Nattamai, MSc, Jose A Cancelas, MD PhD, Hartmut Geiger, PhD

Blood (2015) 126 (23): 665.

https://doi.org/10.1182/blood.V126.23.665.665

Published: 2015

Journal Articles

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Jung-Mi Lee, PhD, Bryan Goddard, Ashwini S. Hinge, PhD, Bruce J. Aronow, PhD, Nathan Salomonis, PhD, Marie-Dominique Filippi, PhD, H. Leighton Grimes, PhD, Jose A Cancelas, MD PhD, Damien Reynaud, PhD

Blood (2015) 126 (23): 245.

https://doi.org/10.1182/blood.V126.23.245.245

Published: 2015

Journal Articles

Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche

Kyung-Hee Chang, PhD, Amitava Sengupta, PhD, Ramesh C Nayak, Angeles Duran, Sang Jun Lee, Ronald Pratt, Ashley Wellendorf, Sarah Hill, Marcus Watkins, Roberto Civitelli, Daniel T Starczynowski, PhD, Maria T Diaz-Meco, Jorge Moscat, Jose A Cancelas, MD PhD

Blood (2014) 124 (21): 350.

https://doi.org/10.1182/blood.V124.21.350.350

Published: 2014

Journal Articles

Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy

Swarnava Roy, PhD, Diamantis G. Konstantinidis, PhD, Tilat Rizvi, PhD, Kyung-Hee Chang, PhD, Nambirajan Sundaram, Michael Wourms, M.Sc., Loberg Anastacia, Lanxi Song, Katie Burke, Tadashi Inagami, PhD, Nancy Ratner, PhD, David Witte, MD, Theodosia A. Kalfa, M.D., Ph.D., Jose A Cancelas, MD, PhD, Shiva Kumar Shanmukhappa, PhD, Punam Malik, MD

Blood (2013) 122 (21): 2211.

https://doi.org/10.1182/blood.V122.21.2211.2211

Published: 2013

Journal Articles

Kruppel-Like-Factor 5 (Klf-5) Controls Hematopoietic Stem Cell/Progenitor Bone Marrow Homing and Lodging Through Rab5-Mediated Expression of Active β 1 Integrin

Eri Taniguchi Ishikawa, PhD, Kyung-Hee Chang, PhD, H. Andre Olsson, Ph.D, Ramesh C Nayak, Ph.D., Ashley Ficker, Susan K Dunn, Amitava Sengupta, PhD, Jeffrey Whitsett, MD, H. Leighton Grimes, PhD, Jose A Cancelas, MD, PhD

Blood (2012) 120 (21): 113.

https://doi.org/10.1182/blood.V120.21.113.113

Published: 2012

Journal Articles

Rac2 GTPase Activation Is Necessary for Development of p190-BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia

Abel Sanchez-Aguilera, PhD, Ami tava Sengupta, PhD, Joseph P Mastin, B.S., Kyung H Chang, PhD, David A Williams, MD, Jose A Cancelas, MD, PhD

Blood (2008) 112 (11): 3790.

https://doi.org/10.1182/blood.V112.11.3790.3790

Published: 2008

Journal Articles

FIP1L1/PDGFRa Synergizes with SCF/c-Kit Signaling To Induce Systemic Mastocytosis in a Chronic Eosinophilic Leukemia Murine Model

Yoshiyuki Yamada, MD, PhD, Jose A. Cancelas, MD, PhD, Eric B. Brandt, PhD, Abel Sanchez-Aguilera, PhD, Melissa McBride, BS, Nabel J.H. Al-Moamen, BS, Fred Finkelman, MD, David A. Williams, MD, Marc E. Rothenberg, MD, PhD

Blood (2007) 110 (11): 1540.

https://doi.org/10.1182/blood.V110.11.1540.1540

Published: 2007

Journal Articles

Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation.

Theodosia A. Kalfa, MD, PhD, Suvarnamala Pushkaran, Jose A. Cancelas, MD, PhD, James F. Johnson, Deidre Daria, Hartmut Geiger, PhD, David A. Williams, MD, Yi Zheng, PhD

Blood (2007) 110 (11): 1714.

https://doi.org/10.1182/blood.V110.11.1714.1714

Published: 2007

Journal Articles

Dissection of the Role of Connexin-43 in Hematopoietic Progenitors and Stromal Cells Unveils Distinct Hematopoietic Intrinsic and Extrinsic Regulatory Functions.

Lina Li, DDS, PhD, Bhuvana Murali, MS, Dealma N. Worsham, MS, Susan K. Dunn, MT, Jose A. Cancelas, MD, PhD

Blood (2007) 110 (11): 607.

https://doi.org/10.1182/blood.V110.11.607.607

Published: 2007

NARROW

Bone Marrow Hematopoietic Connexin 43 Is Required for Mitotransfer and AMPK Dependent Mesenchymal Microenvironment Regeneration after Irradiation

Connexin-43 Is a Negative Regulator of Mitochondrial Fission, Mitophagy and Apoptosis of Dividing Hematopoietic Stem Cells through the Drp1-Pink1 Axis

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Uncoupling Sickle Hematopoiesis Induced Angiotensin Receptor Signaling in Sickle Nephropathy

Scribble Controls HSC Self-Renewal through Polarity-Dependent Activation of the Hippo Signaling Pathway

TRAF6 Is Essential for Maintaining Hematopoietic Stem Cell Homeostasis

Treatment of Bleeding in Severely Thrombocytopenic Patients with Transfusion of Dimethyl Sulfoxide (DMSO) Cryopreserved Platelets (CPP) Is Safe - Report of a Phase 1 Dose Escalation Safety Trial

Atypical Protein Kinase C λ/I Oncogenic Signaling through the Chromatin Modifier Satb2 Is Required for Leukemic B-Cell Progenitor Differentiation Arrest and Leukemogenesis

Mitochondria Transfer from Hematopoietic Stem and Progenitor Cells to Pdgfrα + /Sca-1 - /CD48 dim BM Stromal Cells Via CX43 Gap Junctions and AMPK Signaling Inversely Regulate ROS Generation in Both Cell Populations

Upregulation of Vav3 Is Required for Leukemogenesis By BCR-ABL through Polycomb Repression Complex Dependent De-Repression of the Cdkn2a Locus

Systemic Inflammation Recruits Ccr7 + Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

EGFR Signaling in Osteoblasts Regulates Circadian Rhythm of HSPC in Circulation

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Sqstm1 Is Required to Retain Hematopoietic Stem Cell/ Progenitors As a Negative Regulator of Macrophage-Dependent Inflammatory Signaling in the Bone Marrow Osteoblastic Niche

Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy

Kruppel-Like-Factor 5 (Klf-5) Controls Hematopoietic Stem Cell/Progenitor Bone Marrow Homing and Lodging Through Rab5-Mediated Expression of Active β 1 Integrin

Rac2 GTPase Activation Is Necessary for Development of p190-BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia

FIP1L1/PDGFRa Synergizes with SCF/c-Kit Signaling To Induce Systemic Mastocytosis in a Chronic Eosinophilic Leukemia Murine Model

Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation.

Dissection of the Role of Connexin-43 in Hematopoietic Progenitors and Stromal Cells Unveils Distinct Hematopoietic Intrinsic and Extrinsic Regulatory Functions.

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American Society of Hematology

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American Society of Hematology

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