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Jumpei Nogami
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Journal Articles

Genoprime-Perturb-seq: Functional dissection of GATA2 variants via simultaneous Genotyping-coupled Prime-editing Perturb-seq

Free
Shigeki Hirabayashi, June Takeda, Kyoko Fukushi, Momoka Tsuruhara, Jumpei Nogami, Yuichiro Semba, Shoko Tarumoto, Ami Kamano, Moe Shinagawa, Daisuke Ishihara, Yuta Kikuchi, Kohta Miyawaki, Koichi Akashi, Takuya Yamamoto, Masahito Ohue, Masataka Ishimura, Kenichi Yoshida, Taro Tsujimura, Takahiro Maeda
Journal: Blood
Blood (2025) 146 (Supplement 1): 3215.
https://doi.org/10.1182/blood-2025-3215
Published: 2025
Journal Articles

Genome-Wide CRISPR/Cas9 Screens Identify DDX19A/DDX19B As a Critical Regulator of Intrinsic Apoptosis By Regulating MCL1 mRNA Cellular Localization

Free
Tatsuya Terasaki, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Hiroshi Imanaga, Fumihiko Nakao, Shigeki Hirabayashi, Jumpei Nogami, Koshi Akahane, Takeshi Inukai, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood (2023) 142 (Supplement 1): 1445.
https://doi.org/10.1182/blood-2023-182620
Published: 2023
Journal Articles

The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53 -Mutated AML

Free
Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Takahiro Maeda, Koichi Akashi
Journal: Blood
Blood (2023) 142 (Supplement 1): 2741.
https://doi.org/10.1182/blood-2023-188986
Published: 2023
Journal Articles

The XPO7/Npat Axis Is a Potential Therapeutic Target for TP53 -Mutated AML

Free
Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood (2022) 140 (Supplement 1): 91–92.
https://doi.org/10.1182/blood-2022-168650
Published: 2022
Journal Articles

A Genome-Wide CRISPR-Cas9 Screen Reveals GATOR1 Complex Is a Critical Regulator of Glucocorticoid Sensitivity in B-Cell Precursor Acute Lymphoblastic Leukemia

Free
Hiroshi Imanaga, Yuichiro Semba, Kensuke Sasaki, Kiyoko Miyata, Takuji Yamauchi, Tatsuya Terasaki, Fumihiko Nakao, Shigeki Hirabayashi, Jumpei Nogami, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood (2022) 140 (Supplement 1): 5979.
https://doi.org/10.1182/blood-2022-164647
Published: 2022
Journal Articles

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2- rearranged Ph-like ALL

Free
Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood (2022) 139 (5): 748–760.
https://doi.org/10.1182/blood.2021012976
Published: 2022
Includes: Supplemental data
Journal Articles

Genome-Wide CRISPR-Cas9 Screen Identifies Rationally Designed Combination Therapies Relevant for CRLF2-Rearranged Ph-like ALL

Free
Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda
Journal: Blood
Blood (2021) 138 (Supplement 1): 2257.
https://doi.org/10.1182/blood-2021-152027
Published: 2021
Journal Articles

CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53 -Mutated AML

Free
Yuichiro Semba, MD PhD, Takuji Yamauchi, MD PhD, Fumihiko Nakao, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Luca Pinello, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3784.
https://doi.org/10.1182/blood-2019-129623
Published: 2019
Journal Articles

CRISPR-Cas9 Screen Identifies Me2 , a Mitochondrial Malic Enzyme, As a Molecule Relevant for MCL1 Inhibitor Resistance in AML

Free
Fumihiko Nakao, MD, Takuji Yamauchi, MD PhD, Yuichiro Semba, MD PhD, Jumpei Nogami, PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 912.
https://doi.org/10.1182/blood-2019-129237
Published: 2019
Journal Articles

Paics, a De Novo Purine Synthetic Enzyme, Is a Novel Target for AML Therapy

Free
Takuji Yamauchi, MD PhD, Kohta Miyawaki, MD, Yuichiro Semba, MD PhD, Fumihiko Nakao, MD, Takeshi Sugio, MD PhD, Kensuke Sasaki, MD, Jumpei Nogami, PhD, Matthew C. Canver, MD PhD, Simon Osborne, PhD, Luca Pinello, PhD, Deborah Taylor, PhD, Daniel E. Bauer, MD PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1390.
https://doi.org/10.1182/blood-2019-127047
Published: 2019
Journal Articles

A Fast and Accurate Diagnostic Method for Ph-like ALL Using the Ncounter System

Free
Kensuke Sasaki, MD, Kohta Miyawaki, MD PhD, Yuichiro Semba, MD PhD, Koji Kato, MD PhD, Jumpei Nogami, PhD, Takeshi Sugio, MD PhD, Toshihiro Miyamoto, MD PhD, Yoshikiyo Ito, MD PhD, Koji Nagafuji, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 375.
https://doi.org/10.1182/blood-2019-129625
Published: 2019