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Journal Articles

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Nicholas Casey, PhD, Hiroshi Fujiwara, MD PhD, Kazushi Tanimoto, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, Masaki Yasukawa, MD PhD

Blood (2015) 126 (23): 4291.

https://doi.org/10.1182/blood.V126.23.4291.4291

Published: 2015

Journal Articles

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Hiroaki Ikeda, MD PhD, Yasushi Akahori, PhD, Motohiro Yoneyama, Yuki Orito, Yoshihiro Miyahara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Hiroshi Fujiwara, MD PhD, Masaki Yasukawa, MD PhD, Hiroshi Shiku, MD PhD

Blood (2015) 126 (23): 4292.

https://doi.org/10.1182/blood.V126.23.4292.4292

Published: 2015

Journal Articles

Tumor-Specific TCR-Engineered Donor Lymphocyte Infusion Therapy with Reduced GvHD Induction Utilizing Novel Retrovirus Vector Silencing Endogenous TCR Expression

Hiroaki Ikeda, MD PhD, Hiroaki Ueno, Isao Tawara, MD, PhD, Ayumi Kawamura, Naoko Imai, MD PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kazutoh Takesako, PhD, Naoyuki Katayama, MD PhD, Hiroshi Shiku, MD PhD

Blood (2014) 124 (21): 656.

https://doi.org/10.1182/blood.V124.21.656.656

Published: 2014

Journal Articles

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Kazushi Tanimoto, MD PhD, Hiroshi Fujiwara, MD PhD, Hiroki Tanaka, MD, Fumihiro Ochi, MD, Hiroaki Asai, MDPhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD PhD, Hiroshi Shiku, MD PhD, John Barrett, MD, Masaki Yasukawa, MD PhD

Blood (2014) 124 (21): 307.

https://doi.org/10.1182/blood.V124.21.307.307

Published: 2014

Journal Articles

Engineering of CD19-CAR T Cells from Non-Hodgkin Lymphoma Patients in a Closed System in Combination with Retronectin/OKT3 Stimulation

Hideto Chono, PhD, Kenichi Tahara, PhD, Ikuei Nukaya, PhD, Junichi Mineno, PhD, Eisuke Uehara, MD PhD, Tomonori Tsukahara, PhD, Ken Ohmine, MD PhD, Keiya Ozawa, MD PhD, Kazutoh Takesako, PhD

Blood (2014) 124 (21): 2446.

https://doi.org/10.1182/blood.V124.21.2446.2446

Published: 2014

Journal Articles

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, MD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, PhD, Yukihiro Miyazaki, MD, PhD, Taichi Azuma, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2013) 122 (21): 144.

https://doi.org/10.1182/blood.V122.21.144.144

Published: 2013

Journal Articles

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Junichi Mineno, PhD, Miwako Narita, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 3153.

https://doi.org/10.1182/blood.V120.21.3153.3153

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, Yukihiro Miyazaki, MD, Hiroaki Asai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 1902.

https://doi.org/10.1182/blood.V120.21.1902.1902

Published: 2012

Journal Articles

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Yukihiro Miyazaki, MD, Fumihiro Ochi, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 4221.

https://doi.org/10.1182/blood.V120.21.4221.4221

Published: 2012

Journal Articles

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Hiroaki Asai, MD, Yukihiro Miyazaki, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 645.

https://doi.org/10.1182/blood.V118.21.645.645

Published: 2011

Journal Articles

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Hiroaki Asai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, PhD, Toshiaki Shirakata, MD, PhD, Kozo Nagai, MD, Yukihiro Miyazaki, MD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 2059.

https://doi.org/10.1182/blood.V118.21.2059.2059

Published: 2011

Journal Articles

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Hiroaki Asai, MD, Kozo Nagai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2011) 118 (21): 4169.

https://doi.org/10.1182/blood.V118.21.4169.4169

Published: 2011

Journal Articles

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Toshiki Ochi, MD, PhD, Hiroshi Fujiwara, MD, PhD, Sachiko Okamoto, PhD, Jun An, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 1020.

https://doi.org/10.1182/blood.V116.21.1020.1020

Published: 2010

Journal Articles

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, Jun An, MD, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, J. Joseph Melenhorst, PhD, Emma Gostic, David A Price, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4290.

https://doi.org/10.1182/blood.V116.21.4290.4290

Published: 2010

Journal Articles

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Yukihiro Miyazaki, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, MD, PhD, An Jun, MD, Toshiaki Shirakata, Kozo Nagai, MD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2010) 116 (21): 4295.

https://doi.org/10.1182/blood.V116.21.4295.4295

Published: 2010

Journal Articles

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

Toshiki Ochi, MD, Hiroshi Fujiwara, MD, PhD, Kozo Nagai, MD, Toshiaki Shirakata, MD, PhD, Kiyotaka Kuzushima, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Hiroshi Shiku, MD, PhD, Hidetoshi Ozawa, PhD, Fumihiko Ishikawa, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2009) 114 (22): 3028.

https://doi.org/10.1182/blood.V114.22.3028.3028

Published: 2009

Journal Articles

Development of a Novel Anti-Leukemia Gene Immunotherapy Using Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer.

Kozo Nagai, MD, Hiroshi Fujiwara, MD, PhD, Toshiki Ochi, Toshiaki Shirakata, MD, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2009) 114 (22): 375.

https://doi.org/10.1182/blood.V114.22.375.375

Published: 2009

NARROW

Targeting Aurora Kinase with a Superior T-Cell Receptor Gene-Transfer Vector

Immunotherapy with Chimeric Antigen Receptor Targeting Intracellular WT1 Gene Product Complexed with HLA-a*24:02 Molecule

Tumor-Specific TCR-Engineered Donor Lymphocyte Infusion Therapy with Reduced GvHD Induction Utilizing Novel Retrovirus Vector Silencing Endogenous TCR Expression

Concomitant Administration of Gene-Modified T Cells Expressing a Chimeric CD16-CD3ζ Receptor with Mogamulizmab Synergistically Suppresses Adult T Cell Leukemia Cells in Vivo

Engineering of CD19-CAR T Cells from Non-Hodgkin Lymphoma Patients in a Closed System in Combination with Retronectin/OKT3 Stimulation

Co-Administration Of Gene-Modified CD4 + T Cells Targeting HLA Class I-Restricted WT1 Epitope Diversely Enhances The Antitumor Effect Mediated By Redirected T-Cell Based Adoptive Immunotherapy Against Human Leukemia

Redirected CD4 + T Cells towards HLA Class I-Restricted WT1 Epitope Successfully Display Multifactorial Helper Function for the Enhancement of Antileukemia Efficacy Mediated by Redirected T-Cell Based Immunocelltherapy.

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Therapeutically Infused Redirected T Cells Targeting WT1 Successfully Inhibited Leukemia Stem Cells in Vivo

Redirected CD4 + T Cells Using WT1-Specific T-Cell Receptor Gene Transfer Can Supply Multifactorial Help to Enhance the Anti-Leukemia Reactivity Mediated by Similarly Redirected CD8 + T Cells Using the Identical Gene Transfer

Forced Expression of CC Chemokine Receptor 2 Enhances Anti-Cancer Reactivity Mediated by T Lymphocytes Beforehand Redirected Toward WT1 Inside the Tumor Microenvironment

Human Telomerase Reverse Transcriptase-Specific T-Cell Receptor Gene Transfer Redirects T-Lymphocytes to Exert Effective Antitumor Reactivity Against Adult T-Cell Leukemia,

Augmented Expression of WT1-Specific TCR and Inhibition of Mispaired-TCR Formation In TCR-Gene Modified T-Cells Can Concomitantly Be Achieved Using a Novel Retroviral Vector with Silencers for Endogenous TCRs

Engineering of Human T-Cells with a Novel Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer Confers Anti-Leukemia Reactivity

Dual Engineering of Human CD8 + T-Cells with WT1-Specific TCR Gene and Chemokine Receptor Gene Transfer Confers Functionally Strengthened Anti-Cancer Reactivity

Development of Novel Stem Cell Transplantation and Gene-Immunotherapy Using WT1-Specific T-Cell Receptor Gene.

Development of a Novel Anti-Leukemia Gene Immunotherapy Using Aurora-A Kinase-Specific T-Cell Receptor Gene Transfer.

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American Society of Hematology

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American Society of Hematology

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